Strain SummaryB6;129S-Cdkn1btm1Ako Nkx3-1tm1Mms Ptentm1Rps/+

Strain Name

B6;129S-Cdkn1btm1Ako Nkx3-1tm1Mms Ptentm1Rps/+

Strain Type(s)

targeted mutation (knockout)

Strain Synonym(s)

Nkx3.1-/-; Pten+/-; p27-/-

Description

Mice homozygous for Nkx3-1tm1Mms and Cdkn1btm1Ako, heterozygous for Ptentm1Rps. The genetic background was a mix of C57BL/6J, 129S1/Sv, and 129S3/SvImJ.

Strain Genetics

Ptentm1Rps / Pten+
Cdkn1btm1Ako / Cdkn1btm1Ako
Nkx3-1tm1Mms / Nkx3-1tm1Mms

Models

2 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Prostate gland - Dorsolateral lobe prostatic intraepithelial neoplasia - low grade (LGPIN) Prostate gland - Dorsolateral lobe

observed

References: Gao H, Proc Natl Acad Sci U S A 2004 Dec 7;101(49):17204-9

5 pathology image(s)

Prostate gland prostatic intraepithelial neoplasia - low grade (LGPIN) Prostate gland

observed

References: Gao H, Proc Natl Acad Sci U S A 2004 Dec 7;101(49):17204-9