Strain SummaryB6;129-Trp53tm1Brd
Strain Name |
B6;129-Trp53tm1Brd |
Strain Type(s) |
targeted mutation (knockout) |
Strain Synonym(s) |
C57B6/129Sv (-/-) • C57B6/129Sv mixed p53 null (-/-) • TSG-p53-/- • p53-deficient • p53 null (-/-) • p53-/- • TSG-p53 • TSG-p53-null |
Description |
Homozygous mice. The genetic background of these mice was a mixture of C57BL/6 and "129/Sv" (substrain not specified but included at least some 129S7/SvEvBrd-Hprt1+). These mice were from Taconic. |
Strain Genetics |
Trp53tm1Brd / Trp53tm1Brd |
Frequency | ||||||||
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Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
Blood vessel hemangiosarcoma | Blood vessel |
4.35 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 |
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Bone osteosarcoma | Bone |
0 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 |
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CNS - Brain - Astrocyte astrocytoma - anaplastic | CNS - Brain - Astrocyte |
4.35 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 |
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CNS - Brain glioma | CNS - Brain | Moloney Murine Leukemia Virus (MoMuLV) containing Pdgfb ⋅ Moloney Murine Leukemia helper virus |
observed |
References: Johansson FK, Proc Natl Acad Sci U S A 2004 Aug 3;101(31):11334-7 |
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CNS - Brain tumor | CNS - Brain | Moloney Murine Leukemia Virus (MoMuLV) containing Pdgfb |
89.47 |
References: Hesselager G, Cancer Res 2003 Aug 1;63(15):4305-9 |
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CNS - Brain tumor | CNS - Brain | MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV) |
0 |
References: Hesselager G, Cancer Res 2003 Aug 1;63(15):4305-9 |
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CNS - Meninges meningioma | CNS - Meninges |
0 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 |
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Germ cell (sex not specified) teratoma | Germ cell (sex not specified) |
0 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 |
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Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon |
0 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 |
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Intestine - Small Intestine tumor | Intestine - Small Intestine |
0 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 |
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Leukocyte lymphoma - non-Hodgkin | Leukocyte |
91 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 Sites of Metastasis: not Seminal vesicle , Adrenal gland , Bone marrow , CNS - Meninges , Heart , Kidney , Liver , Lung , Lymph node , Ovary , Pancreas , Salivary gland , Spleen , Testis , Thymus |
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Leukocyte lymphoma - non-Hodgkin | Thymus |
26 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 |
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Leukocyte lymphoma - non-Hodgkin | Spleen |
52 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 |
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Leukocyte lymphoma - non-Hodgkin | Lymph node |
13 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 |
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Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
8.7 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 |
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Prostate gland tumor | Prostate gland |
0 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 |
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(Unspecified organ) tumor - undifferentiated | (Unspecified organ) |
4.35 |
References: van Meyel DJ, Int J Oncol 1998 Nov;13(5):917-22 |