Strain Summary129S4.129S2-Nf1^tm1Tyj Trp53^tm1Tyj/+ +

Strain Name	129S4.129S2-Nf1^tm1Tyj Trp53^tm1Tyj/+ +
Strain Type(s)	congenic • targeted mutation (knockout)
Strain Synonym(s)	129S4.129S2-Nf1^tm1Tyj/+ Trp53^tm1Tyj/+ • NPcis • NPcis-129
Description	Mice heterozygous for Nf1 and Trp53 mutations on 129S4.129S2 backgrounds were crossed to make "trans" mice (alleles on opposite chromosomes). Mice were crossed to 129S4/SvJae mice to produce "cis" mice (alleles on the same chromosome).
Strain Genetics	List all models in MMHCdb carrying the Nf1^tm1Tyj allele Nf1^tm1Tyj / Nf1⁺
	List all models in MMHCdb carrying the Trp53^tm1Tyj allele Trp53^tm1Tyj / Trp53⁺

Models
5 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Adrenal gland - Medulla pheochromocytoma	Adrenal gland - Medulla				3.0		References: Reilly KM, Proc Natl Acad Sci U S A 2004 Aug 31;101(35):13008-13
CNS - Brain - Astrocyte astrocytoma	CNS - Brain - Astrocyte				21		References: Reilly KM, Proc Natl Acad Sci U S A 2004 Aug 31;101(35):13008-13 1 pathology image(s)
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma	Leukocyte - Monocyte - Macrophage - Histiocyte				21		References: Reilly KM, Proc Natl Acad Sci U S A 2004 Aug 31;101(35):13008-13
Leukocyte lymphoma	Leukocyte				6.1		References: Reilly KM, Proc Natl Acad Sci U S A 2004 Aug 31;101(35):13008-13
Mesodermal cell/mesoblast sarcoma	Mesodermal cell/mesoblast				64		References: Reilly KM, Proc Natl Acad Sci U S A 2004 Aug 31;101(35):13008-13

Models