Strain Summary(CBA/J x B6.129S2)F1-Nf1^tm1Tyj Trp53^tm1Tyj/+ +

Strain Name	(CBA/J x B6.129S2)F1-Nf1^tm1Tyj Trp53^tm1Tyj/+ +
Strain Type(s)	hybrid • targeted mutation (knockout)
Strain Synonym(s)	(CBA/J x B6.129S2)F1-Nf1^tm1Tyj/+ Trp53^tm1Tyj/+ • NPcis-B6XCB
Description	These mice were heterozygous for Nf1^tm1Tyj & Trp53^tm1Tyj on the same chromosome 11 ("cis"). Genetic background was approximately 50% CBA/J and 50% C57BL/6J. The sex of the mutant mice used in this cross was not given.
Strain Genetics	List all models in MMHCdb carrying the Nf1^tm1Tyj allele Nf1^tm1Tyj / Nf1⁺
	List all models in MMHCdb carrying the Trp53^tm1Tyj allele Trp53^tm1Tyj / Trp53⁺

Models
5 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Adrenal gland - Medulla pheochromocytoma	Adrenal gland - Medulla				12		References: Reilly KM, Proc Natl Acad Sci U S A 2004 Aug 31;101(35):13008-13
CNS - Brain - Astrocyte astrocytoma	CNS - Brain - Astrocyte				31		References: Reilly KM, Proc Natl Acad Sci U S A 2004 Aug 31;101(35):13008-13
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma	Leukocyte - Monocyte - Macrophage - Histiocyte				29		References: Reilly KM, Proc Natl Acad Sci U S A 2004 Aug 31;101(35):13008-13
Leukocyte lymphoma	Leukocyte				16		References: Reilly KM, Proc Natl Acad Sci U S A 2004 Aug 31;101(35):13008-13
Mesodermal cell/mesoblast sarcoma	Mesodermal cell/mesoblast				64		References: Reilly KM, Proc Natl Acad Sci U S A 2004 Aug 31;101(35):13008-13

Models