Strain SummaryC57BL/6J-Cdkn1atm1Tyj Cdkn1btm1Mlf

Strain Name

 C57BL/6J-Cdkn1atm1Tyj Cdkn1btm1Mlf

Strain Type(s)

 targeted mutation (knockout)

Strain Synonym(s)

 p21-/-p27-/-

Description

 Double homozygous mice. The genetic background of these mice was C57BL/6J. These mice were generated by crossing two congenic knockout strains.

Strain Genetics

 Cdkn1atm1Tyj / Cdkn1atm1Tyj
Cdkn1btm1Mlf / Cdkn1btm1Mlf

Models

11 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

22.2

References: Garcia-Fernandez RA, Lab Invest 2011 Nov;91(11):1634-42

Blood vessel hemangioma Blood vessel

0

References: Garcia-Fernandez RA, Lab Invest 2011 Nov;91(11):1634-42

Eye - Harderian gland adenoma Eye - Harderian gland

5.6

References: Garcia-Fernandez RA, Lab Invest 2011 Nov;91(11):1634-42

Leukocyte - Lymphocyte - B-lymphocyte lymphoma Leukocyte - Lymphocyte - B-lymphocyte

5.6

References: Garcia-Fernandez RA, Lab Invest 2011 Nov;91(11):1634-42

Leukocyte - Lymphocyte - T-lymphocyte lymphoma Thymus gamma-radiation

33

References: Garcia-Fernandez RA, Lab Invest 2011 Nov;91(11):1634-42

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

11.1

References: Garcia-Fernandez RA, Lab Invest 2011 Nov;91(11):1634-42

Liver hepatocellular adenoma Liver

5.6

References: Garcia-Fernandez RA, Lab Invest 2011 Nov;91(11):1634-42

Mammary gland adenocarcinoma Mammary gland

5.6

References: Garcia-Fernandez RA, Lab Invest 2011 Nov;91(11):1634-42

Pituitary gland - Pars intermedia adenoma Pituitary gland - Pars intermedia

33.3

References: Garcia-Fernandez RA, Lab Invest 2011 Nov;91(11):1634-42

Thyroid gland adenoma Thyroid gland

11.1

References: Garcia-Fernandez RA, Lab Invest 2011 Nov;91(11):1634-42

(Unspecified organ) tumor (Unspecified organ)

72.2

References: Garcia-Fernandez RA, Lab Invest 2011 Nov;91(11):1634-42