Strain SummaryB6;129-Krastm4.1Bbd
Strain Name |
B6;129-Krastm4.1Bbd |
Strain Type(s) |
targeted mutation (knock-in) |
Strain Synonym(s) |
AVB line • B6/129-KRasV14I • C57BL/6J.OlaHsd/129S2/SvPasCrl-KRasV14I • K-RasV14I • K-RasV14I/V14I |
Description |
Homozygous mice. The genetic background of these mice was a mixture of C57BL/6 and 129 (including at least 129X1/SvJ and/or 129S1/Sv) and possibly some other strain(s). |
Strain Genetics |
Krastm4.1Bbd / Krastm4.1Bbd |
| Frequency | ||||||||
|---|---|---|---|---|---|---|---|---|
| Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
| Epididymis adenoma | Epididymis |
0 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||||
| Intestine adenoma | Intestine |
0 |
0 |
0 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| Leukocyte - Lymphocyte - B-lymphocyte lymphoma | Leukocyte - Lymphocyte - B-lymphocyte |
0 |
0 |
0 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
20 |
29 |
25 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| Leukocyte - Myelocyte (Granulocyte) hyperplasia | Leukocyte - Myelocyte (Granulocyte) |
40 |
29 |
33 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| Leukocyte - Myelocyte (Granulocyte) hyperplasia | Spleen |
100 |
observed |
References: Hernandez-Porras I, Proc Natl Acad Sci U S A 2014 Nov 18;111(46):16395-400 ⋅ Hernandez-Porras I, Rare Dis 2015;3(1):e1045169 |
||||
| Leukocyte - Myelocyte (Granulocyte) hyperplasia | Spleen | PD0325901 (MEK inhibitor) |
100 |
References: Hernandez-Porras I, Proc Natl Acad Sci U S A 2014 Nov 18;111(46):16395-400 |
||||
| Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0 |
0 |
0 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| Leukocyte lymphoma | Leukocyte |
60 |
71 |
67 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| Leukocyte lymphoma - lymphoblastic | Leukocyte |
0 |
0 |
0 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| Liver adenocarcinoma | Liver |
0 |
0 |
0 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| Liver adenoma | Liver |
0 |
0 |
0 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| Lung adenocarcinoma | Lung |
0 |
0 |
0 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| Lung adenoma | Lung |
0 |
0 |
0 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| Pituitary gland - Anterior adenocarcinoma | Pituitary gland - Anterior |
20 |
0 |
8.3 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| (Unspecified organ) adenocarcinoma | (Unspecified organ) |
20 |
0 |
8.3 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| (Unspecified organ) adenoma | (Unspecified organ) |
0 |
0 |
0 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| (Unspecified organ) angiosarcoma | (Unspecified organ) |
0 |
0 |
0 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||
| (Unspecified organ) tumor | (Unspecified organ) |
80 |
71 |
75 |
References: Hernandez-Porras I, J Pathol 2016 Jun;239(2):206-17 |
|||