Strain Summary[not specified]-Calca^{tm1.1(cre/ERT2)Ptch}/+ Rb1^tm2Brn Trp53^tm1Brn

Strain Name	[not specified]-Calca^{tm1.1(cre/ERT2)Ptch}/+ Rb1^tm2Brn Trp53^tm1Brn
Strain Type(s)	targeted mutation (conditional) • targeted mutation (knock-in)
Strain Synonym(s)	DKO • double knock-out • CGRP^CreER/+; p53^f/f; Rb^f/f • p53^-/-; Rb^-/- • p53/Rb-deficient • p53/Rb DKO
Description	Compound mutant mice. The genetic background of these mice was not specified but included at least some 129P2/OlaHsd, 129 (substrain not specified), FVB, and possibly some other strain(s).
Strain Genetics	List all models in MMHCdb carrying the Rb1^tm2Brn allele Rb1^tm2Brn / Rb1^tm2Brn
	List all models in MMHCdb carrying the Calca^{tm1.1(cre/ERT2)Ptch} allele Calca^{tm1.1(cre/ERT2)Ptch} / Calca⁺
	List all models in MMHCdb carrying the Trp53^tm1Brn allele Trp53^tm1Brn / Trp53^tm1Brn

Models
2 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Thyroid gland - Medulla - C cell carcinoma	Thyroid gland - Medulla - C cell	tamoxifen (for inducing expression from mutant alleles)			100		References: Song H, J Biol Chem 2017 Mar 3;292(9):3888-3899 2 pathology image(s)
Thyroid gland - Medulla - C cell hyperplasia	Thyroid gland - Medulla - C cell	tamoxifen (for inducing expression from mutant alleles)			100		References: Song H, J Biol Chem 2017 Mar 3;292(9):3888-3899 1 pathology image(s)

Models