Model DetailsThyroid gland - Medulla - C cell carcinoma

Model Name

 Thyroid gland - Medulla - C cell carcinoma

Strain
[not specified]-Calcatm1.1(cre/ERT2)Ptch/+ Ptentm1Hwu Rb1tm2Brn Trp53tm1Brn

Tumor Inducing Agent(s)

 Genetic Modification : tamoxifen (for inducing expression from mutant alleles)

Tumor Synonyms

 medullary thyroid carcinoma  •  medullary thyroid tumor  •  thyroid tumor

Strain Synonyms

 p53/Rb/Pten TKO  •  p53/Rb/Pten-deficient  •  CGRPCreER/+; p53f/f; Rbf/f; Ptenf/f  •  p53-/-; Rb-/-; Pten-/-  •  triple knock-out  •  TKO
Organ Affected Sex Frequency Age Of Detection Additional Information Expand all Collapse all Reference
Thyroid gland - Medulla - C cell Mixed Population

100%

(51 of 51 mice) 		3-4 months
  • Treatment Notes
  • Notes

    Reproductive Status: reproductive status not specified

  • Age of Onset

    ~2.5-3.5 months

  • Genetics
  • Pathology Reports
Song H, J Biol Chem 2017 Mar 3;292(9):3888-3899