PDX Model DetailsJ000077960

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PDX Model Summary

Model Details
Model ID
J000077960
Initial Diagnosis
Pancreas adenocarcinoma
Final Diagnosis
Pancreatic ductal adenocarcinoma
Stage/Grade
AJCC IV / Grade:2
Primary Site
Pancreas
Sample Site
Pancreas
Tumor Type
Primary Malignancy

Related Models

 PDX models J000077960 and J000077973 originated from the same patient.

Patient
Sex
Female
Age (at time of tissue collection)
68
Race/Ethnicity
White / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

no CNV data

CNV Plots

no CNV plots

Tumor Mutation Burden
Sample J000093248 from passage P0 has a TMB score of 3.23
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:J000093248 from passage P0     Score:MSI-S

Gene Fusion
Fusion Genes
Sample J000093249 has fusion genes PDXDC1--NPIPB14P, PKD1--NPIPP1, ZNF655--TMEM225B, SAA1--SAA4, UPK3B--PMS2P11, SMURF2P1--LRRC37B, LEPROT--LEPR, POLR2J2--AC004951.2, BOLA2B--SMG1P2, PCAT1--MYC, TNFRSF10B--AC107959.1, PVT1--PCAT1, GON4L--AL353807.5, SAA4--SAA1, NDUFB8--SEC31B, CENPS--CORT, RBM14--RBM4, AC004596.1--AC003102.1, TRPC4AP--UQCC1, LAMC2--AL354953.1, CCDC32--CBX3, PVT1--CASC8, RBM14--RBM4B, SEPTIN7P2--PSPH, CAPN8--CAPN2, AC013268.1--MALL, ARHGEF5--OR2A7, CASC19--CASC11, PVT1--AC087667.1, CLN6--CALML4, OSBPL1A--TTC39C-AS1, ASAP1--WASHC5, SLC29A1--HSP90AB3P, TSTD1--F11R, ARPC4--TTLL3, STX16--NPEPL1

Model Characterization

Histology

 Summary:
P0, P1 pathology consistent with pancreatic adenocarcinoma. 4x and 20x PT images were diagnosed as colonic adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model J000077960 stained for H&E.
Patient tumor for PDX model J000077960 stained for H&E. This is a 4x image.

Patient tumor for PDX model J000077960 stained for H&E. This is a 20x image.
P0 tumor for PDX model J000077960 stained for H&E.

P0 tumor for PDX model J000077960 stained for CD45. Staining was negative.
P0 tumor for PDX model J000077960 stained for AE1/AE3. Staining was positive.

P1 tumor F004 P1 ID006 for PDX model J000077960 stained for H&E.
P1 tumor F004 P1 ID006 for PDX model J000077960 stained for CD45. Staining was negative.

P1 tumor F004 P1 ID006 for PDX model J000077960 stained for AE1/AE3. Staining was positive.

Dosing Studies

 no data

Circos Plots

 no data