PDX Model DetailsJ000095635

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PDX Model Summary

Model Details
Model ID
J000095635
Initial Diagnosis
Mucinous adenocarcinoma
Final Diagnosis
Mucinous adenocarcinoma
Stage/Grade
AJCC IV /
Model Status
Active Available - PDX Resource Gold Standard
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Patient
Sex
Male
Age (at time of tissue collection)
69
Race/Ethnicity
Not Reported / Not Hispanic or Latino
Treatment Naïve?
Unknown
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Core needle biopsy
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

 Data Links:

Sample:J000097360 from passage:P0 Platform:CTP Derived Data  Raw data 1  Raw data 2 


Gene Expression

 Data Links:

Sample:J000097361 from passage:P0 Platform:RNA_Seq Derived Data  Raw data 1  Raw data 2 


Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

 Data Links:

Sample:J000097360 from passage:P0 Platform:SNP Derived Data  Raw data 1 


CNV Plots

Tumor Mutation Burden
Sample J000097360 from passage P0 has a TMB score of 7.27
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:J000097360 from passage P0     Score:MSI-S

Gene Fusion
Fusion Genes
Sample J000097361 has fusion genes PDXDC1--NPIPB14P, CLCF1--POLD4, VAMP8--VAMP5, BOLA2B--SMG1P2, GON4L--AL353807.5, Z97634.1--NME4, C8orf76--NSMCE2, TPTEP2--CSNK1E, LAMC2--AL354953.1, CCDC32--CBX3, C8orf76--ASAP1, RBM14--RBM4B, NSF--LRRC37A3, CYRIB--LINC02235, AL391056.1--NTMT1, ARHGEF5--OR2A7, LINC02257--LINC01655, SCNN1A--TNFRSF1A, C17orf99--SYNGR2, CRIP2--CRIP1, SLC29A1--HSP90AB3P, UPK3B--PMS2P9, ARPC4--TTLL3, SLC49A3--ATP5ME, AC124944.2--SDHAP1

Model Characterization

Histology

 Summary:
P0, P1 pathology consistent with mucinous adenocarcinoma. 4x and 20x images of primary tumor are given diagnosis of poorly differentiated non-small cell carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor (PT) for PDX model J000095635 stained for H&E.
Patient tumor for PDX model J000095635 stained for H&E. This is a 4x image.

Patient tumor for PDX model J000095635 stained for H&E. This is a 20x image.
P0 tumor for PDX model J000095635 stained for H&E.

P1 tumor ID006 for PDX model J000095635 stained for H&E.
P2 tumor F002 P2 ID013 for PDX model J000095635 stained for H&E.

P2 tumor F002 P2 ID013 for PDX model J000095635 stained for AE1AE3. Staining was positive.
P2 tumor F002 P2 ID013 for PDX model J000095635 stained for CD45. Staining was negative

P2 tumor F002 P2 ID013 for PDX model J000095635 stained for KI67. Staining was positive

Dosing Studies

Circos Plots

 no data