Reference SummaryPierre F, Cancer Res 1997 Jan 15;57(2):225-8
Title |
Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice. | ||||
Authors |
Pierre F; Perrin P; Champ M; Bornet F; Meflah K; Menanteau J | ||||
Journal |
Cancer Res | ||||
Volume |
57 | ||||
Issue |
2 | ||||
Year |
1997 | ||||
Pages |
225-8 | ||||
Abstract |
C57BL/6J-Min/+ mice, which are heterozygous for a non-sense mutation in the Apc gene, provide a model for both familial adenomatous polyposis and sporadic colon cancers. In our study, gut tumors and small intestine lymphoid nodules were counted in Min mice fed fiber-enriched diets for 6 weeks. Neither starch-free wheat bran nor resistant starch modified the number of tumors. However, short-chain fructo-oligosaccharides dramatically reduced the incidence of colon tumors and concomitantly developed gut-associated lymphoid tissue. Our experiment shows that short-chain fructo-oligosaccharides counteract advanced stages of colon carcinogenesis, possibly via stimulation of antitumoral immunity by modulation of the colonic ecosystem. | ||||
Links |
J:38422 – MGI References 9000559 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
100 |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
60 - 100 |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine tumor |
|
Intestine - Small Intestine |
100 |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine tumor |
|
Intestine - Small Intestine |
100 |