Strain SummaryC57BL/6J-ApcMin/+
Strain Name |
C57BL/6J-ApcMin/+ |
Strain Type(s) |
chemically induced mutation |
Strain Synonym(s) |
ApcMin/+ • ApcMin • APCmin/+ • APCMin/+ • APCMin/+ • B6-ApcMin • B6-ApcMin/Apc+ • B6 Min/+ • C57BL/6 ApcMin/+ • C57Bl/6-Min • C57BL/6-Min • C57BL/6J-ApcMin/+ • C57BL/6J-APCMin/+ • C57BL/6J/-ApcMin • C57BL/6J-APCmin/+ • C57BL/6J-ApcMin/J • C57BL/6J ApcMin/+ • C57BL/6J-ApcMin/+ • C57BL/6J APCMin/+ • C57BL/6J Apcmin • C57BL/6J-ApcMin • C57BL/6J ApcMin/+ • C57BL/6J-ApcMin/+ • C57BL/6J-ApcMin • C57BL/6J-APCMin/+ • C57BL/6J-ApcMin/J • C57Bl/6J-Min/+ • C57BL/6J Min • C57BL/6J Min/+ • C57BL/6J-Min • C57BL/6J-Min/+ • C57BL/6J/Min/+ • C57Bl/6J-Min+ • C57BL/6J Min • C57BL/6J Min /+ • C57BL/6J-Min/+ • C57Bl/6JMin/+ • C57Bl/6-Min/+ • C57BL/6-Min • adenomatous polyposis coliMin/+ • Apc+/- • Apc+/- Msh2+/+ • ApcMin/+ • ApcMin/+ • APCMin/+ • Apcmin • ApcMin • ApcMin heterozygous • ApcMin • ApcMin/Apc+ • ApcMin/+ • ApcMin • APCMin/+ • Min • Min/+ • Min C57BL/6J • Min/+ C57BL/6J • Min • Min/+ • multiple intestinal neoplasia |
Description |
Heterozygous mice - "Min" mutation |
Strain Links |
• JAX Mice |
Strain Genetics |
ApcMin / Apc+ |
Frequency | ||||||||
---|---|---|---|---|---|---|---|---|
Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
Intestine - Large Intestine - Colon adenocarcinoma | Intestine - Large Intestine - Colon | BRL-49,653, PPAR gamma ligand |
observed |
References: Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 |
||||
Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon |
observed - 100 |
observed - 100 |
0 - observed |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): ⋅ Bjerknes M, Am J Pathol 1999 Jun;154(6):1831-4 ⋅ Chen Q, Life Sci Alliance 2021 Mar;4(3): ⋅ Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 ⋅ Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 ⋅ Shattuck-Brandt RL, Mol Carcinog 1999 Mar;24(3):177-87 ⋅ Wilson CL, Proc Natl Acad Sci U S A 1997 Feb 18;94(4):1402-7 ⋅ Woo DK, Am J Pathol 2012 Jan;180(1):24-31 ⋅ Xie G, JCI Insight 2022 Feb 22;7(4):e150894 3 pathology image(s) |
|||
Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon | N-[4-(3-chloro-4-fluoro-phenylamino)-quinazolin-6-yl]acrylamide (CFPQA) |
observed |
References: Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
||||
Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon | ceramide (N-palmitoylsphingosine) |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon | sphingolipid mix |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon | sphingolipid mix ⋅ ceramide (N-palmitoylsphingosine) |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon | piroxicam |
observed |
References: Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
||||
Intestine - Large Intestine - Colon adenoma - dysplastic | Intestine - Large Intestine - Colon | tamoxifen (for inducing expression from mutant alleles) |
observed |
References: Powell AE, Am J Physiol Gastrointest Liver Physiol 2014 Jul 1;307(1):G16-23 |
||||
Intestine - Large Intestine - Colon adenoma - tubular | Intestine - Large Intestine - Colon |
observed |
References: Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 |
|||||
Intestine - Large Intestine - Colon adenoma - tubular | Intestine - Large Intestine - Colon | tamoxifen (for inducing expression from mutant alleles) |
observed |
References: Powell AE, Am J Physiol Gastrointest Liver Physiol 2014 Jul 1;307(1):G16-23 |
||||
Intestine - Large Intestine - Colon dysplasia - high grade | Intestine - Large Intestine - Colon |
0 |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): |
|||||
Intestine - Large Intestine - Colon dysplasia - low grade | Intestine - Large Intestine - Colon |
15.79 |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): |
|||||
Intestine - Large Intestine - Colon foci - aberrant crypt (ACF) | Intestine - Large Intestine - Colon | 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) |
observed - 93 |
References: Steffensen IL, Cancer Res 2001 Dec 15;61(24):8689-96 |
||||
Intestine - Large Intestine - Colon foci - aberrant crypt (ACF) | Intestine - Large Intestine - Colon |
86 - 90 |
observed |
References: Steffensen IL, Cancer Res 2001 Dec 15;61(24):8689-96 ⋅ Zheng W, Int J Cancer 2012 Jan 1;130(1):10-9 |
||||
Intestine - Large Intestine - Colon polyp | Intestine - Large Intestine - Colon | polyethylene glycol |
observed |
References: Shailubhai K, Cancer Res 2000 Sep 15;60(18):5151-7 |
||||
Intestine - Large Intestine - Colon polyp | Intestine - Large Intestine - Colon | uroguanylin ⋅ polyethylene glycol |
0 - observed |
References: Shailubhai K, Cancer Res 2000 Sep 15;60(18):5151-7 |
||||
Intestine - Large Intestine - Colon polyp | Intestine - Large Intestine - Colon |
observed |
observed - 90.91 |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): ⋅ Gupta RA, Nat Med 2004 Mar;10(3):245-7 ⋅ Mutoh M, Cancer Res 2002 Jan 1;62(1):28-32 ⋅ Zeineldin M, Oncogene 2012 May 10;31(19):2423-37 |
||||
Intestine - Large Intestine - Colon polyp | Intestine - Large Intestine - Colon | 2-[2-{2-(1-naphthyl)propanoylamino}phenyl]methylbenzoic acid (ONO-AE2-227) |
observed |
References: Mutoh M, Cancer Res 2002 Jan 1;62(1):28-32 |
||||
Intestine - Large Intestine - Colon polyp | Intestine - Large Intestine - Colon | GW501516, PPAR-delta agonist |
observed |
References: Gupta RA, Nat Med 2004 Mar;10(3):245-7 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | low fiber |
100 |
References: Pierre F, Cancer Res 1997 Jan 15;57(2):225-8 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | high fiber |
60 - 100 |
References: Pierre F, Cancer Res 1997 Jan 15;57(2):225-8 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon |
observed |
observed |
observed - 45 |
observed - 100 |
References: Barnes CJ, Gastroenterology 1998 May;114(5):873-7 ⋅ Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 ⋅ Ma H, Cell Rep 2020 Jan 21;30(3):793-806.e6 ⋅ Mahmoud NN, Carcinogenesis 1999 Feb;20(2):299-303 ⋅ Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 ⋅ Shattuck-Brandt RL, Gastroenterology 2000 Feb;118(2):337-45 ⋅ Steffensen IL, Cancer Res 2001 Dec 15;61(24):8689-96 ⋅ Weyant MJ, Cancer Res 2001 Jan 1;61(1):118-25 ⋅ Weyant MJ, Cancer Res 2001 Mar 15;61(6):2547-51 ⋅ You S, Cancer Cell 2024 Aug 12;42(8):1415-1433.e12 |
||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | chenodeoxycholate (chenodeoxycholic acid) |
observed |
References: Mahmoud NN, Carcinogenesis 1999 Feb;20(2):299-303 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | sulfasalazine (SASP) |
observed |
References: Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | Pentasa |
observed |
References: Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | 5-aminosalicylic acid, free acid (5-ASA) |
observed |
References: Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | (+)-catechin |
observed |
References: Weyant MJ, Cancer Res 2001 Jan 1;61(1):118-25 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | ovariectomy |
observed |
References: Weyant MJ, Cancer Res 2001 Mar 15;61(6):2547-51 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | 17beta-estradiol (E2) ⋅ ovariectomy |
observed |
References: Weyant MJ, Cancer Res 2001 Mar 15;61(6):2547-51 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) |
observed - 88 |
References: Steffensen IL, Cancer Res 2001 Dec 15;61(24):8689-96 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | BRL-49,653, PPAR gamma ligand |
observed |
References: Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | troglitazone |
observed |
References: Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | aspirin (acetylsalicylic acid) (ASA) |
observed |
References: Barnes CJ, Gastroenterology 1998 May;114(5):873-7 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | tamoxifen (for inducing expression from mutant alleles) |
observed |
References: Powell AE, Am J Physiol Gastrointest Liver Physiol 2014 Jul 1;307(1):G16-23 |
||||
Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon | anti-mouse MHC Class II (M5/115.15.2) |
observed |
References: You S, Cancer Cell 2024 Aug 12;42(8):1415-1433.e12 |
||||
Intestine - Large Intestine - Rectum tumor | Intestine - Large Intestine - Rectum |
observed |
References: Ma H, Cell Rep 2020 Jan 21;30(3):793-806.e6 |
|||||
Intestine - Large Intestine adenocarcinoma | Intestine - Large Intestine |
0 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
|||||
Intestine - Large Intestine adenocarcinoma | Intestine - Large Intestine | NID525, PPAR gamma agonist |
0 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine adenocarcinoma | Intestine - Large Intestine | troglitazone |
6.7 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine adenocarcinoma | Intestine - Large Intestine | pioglitazone |
0 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine adenocarcinoma | Intestine - Large Intestine | rosiglitazone |
0 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine adenoma | Intestine - Large Intestine |
observed - 54 |
60 - 67 |
References: Nakatsugi S, Jpn J Cancer Res 1997 Dec;88(12):1117-20 ⋅ Paulsen JE, Carcinogenesis 1997 Oct;18(10):1905-10 ⋅ Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine adenoma | Intestine - Large Intestine | fish oil |
25 - 33 |
50 - 60 |
References: Paulsen JE, Carcinogenesis 1997 Oct;18(10):1905-10 |
|||
Intestine - Large Intestine adenoma | Intestine - Large Intestine | sulindac |
10 |
References: Boolbol SK, Cancer Res 1996 Jun 1;56(11):2556-60 |
||||
Intestine - Large Intestine adenoma | Intestine - Large Intestine | NID525, PPAR gamma agonist |
100 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine adenoma | Intestine - Large Intestine | troglitazone |
observed |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine adenoma | Intestine - Large Intestine | pioglitazone |
100 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine adenoma | Intestine - Large Intestine | rosiglitazone |
100 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine adenoma | Intestine - Large Intestine | nimesulide (4-nitro-2-phenoxymethanesulfonanilide) |
observed |
References: Nakatsugi S, Jpn J Cancer Res 1997 Dec;88(12):1117-20 |
||||
Intestine - Large Intestine hyperplasia | Intestine - Large Intestine |
observed |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
|||||
Intestine - Large Intestine hyperplasia | Intestine - Large Intestine | NID525, PPAR gamma agonist |
observed |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine hyperplasia | Intestine - Large Intestine | troglitazone |
observed |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine hyperplasia | Intestine - Large Intestine | pioglitazone |
observed |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine hyperplasia | Intestine - Large Intestine | rosiglitazone |
observed |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine polyp | Intestine - Large Intestine |
observed - very low |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): ⋅ Gupta RA, Nat Med 2004 Mar;10(3):245-7 ⋅ Sundberg J, Personal Communication 1997;(): 2 pathology image(s) |
|||||
Intestine - Large Intestine tumor | Intestine - Large Intestine |
observed - 43 |
observed - 100 |
77.78 |
observed |
References: Boolbol SK, Cancer Res 1996 Jun 1;56(11):2556-60 ⋅ Ma H, Cell Rep 2020 Jan 21;30(3):793-806.e6 ⋅ Steffensen IL, Carcinogenesis 1997 May;18(5):1049-54 ⋅ Ton-That H, FEBS Lett 1997 Dec 15;419(2-3):239-43 ⋅ Ziegler CC, J Nutr 2004 Jan;134(1):5-10 |
||
Intestine - Large Intestine tumor | Intestine - Large Intestine | 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) |
14 |
50 |
References: Steffensen IL, Carcinogenesis 1997 May;18(5):1049-54 |
|||
Intestine - Large Intestine tumor | Intestine - Large Intestine | troglitazone |
93 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Large Intestine tumor | Intestine - Large Intestine | resveratrol |
observed |
References: Ziegler CC, J Nutr 2004 Jan;134(1):5-10 |
||||
Intestine - Small Intestine - Distal adenoma | Intestine - Small Intestine - Distal |
observed |
observed - 100 |
References: Nakatsugi S, Jpn J Cancer Res 1997 Dec;88(12):1117-20 ⋅ Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 ⋅ Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Small Intestine - Distal adenoma | Intestine - Small Intestine - Distal | ceramide (N-palmitoylsphingosine) |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Small Intestine - Distal adenoma | Intestine - Small Intestine - Distal | sphingolipid mix |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Small Intestine - Distal adenoma | Intestine - Small Intestine - Distal | sphingolipid mix ⋅ ceramide (N-palmitoylsphingosine) |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Small Intestine - Distal adenoma | Intestine - Small Intestine - Distal | NID525, PPAR gamma agonist |
100 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Small Intestine - Distal adenoma | Intestine - Small Intestine - Distal | nimesulide (4-nitro-2-phenoxymethanesulfonanilide) |
observed |
References: Nakatsugi S, Jpn J Cancer Res 1997 Dec;88(12):1117-20 |
||||
Intestine - Small Intestine - Distal polyp | Intestine - Small Intestine - Distal |
observed |
References: Mutoh M, Cancer Res 2002 Jan 1;62(1):28-32 |
|||||
Intestine - Small Intestine - Distal polyp | Intestine - Small Intestine - Distal | 2-[2-{2-(1-naphthyl)propanoylamino}phenyl]methylbenzoic acid (ONO-AE2-227) |
observed |
References: Mutoh M, Cancer Res 2002 Jan 1;62(1):28-32 |
||||
Intestine - Small Intestine - Distal tumor | Intestine - Small Intestine - Distal | 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) |
observed |
References: Steffensen IL, Cancer Res 2001 Dec 15;61(24):8689-96 |
||||
Intestine - Small Intestine - Distal tumor | Intestine - Small Intestine - Distal | BRL-49,653, PPAR gamma ligand |
observed |
References: Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 |
||||
Intestine - Small Intestine - Distal tumor | Intestine - Small Intestine - Distal |
observed |
observed |
observed |
References: Barnes CJ, Gastroenterology 1998 May;114(5):873-7 ⋅ Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 ⋅ Xie G, JCI Insight 2022 Feb 22;7(4):e150894 |
|||
Intestine - Small Intestine - Distal tumor | Intestine - Small Intestine - Distal | troglitazone |
observed - 100 |
References: Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 ⋅ Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Small Intestine - Distal tumor | Intestine - Small Intestine - Distal | pioglitazone |
100 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Small Intestine - Distal tumor | Intestine - Small Intestine - Distal | rosiglitazone |
100 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Small Intestine - Distal tumor | Intestine - Small Intestine - Distal | aspirin (acetylsalicylic acid) (ASA) |
observed |
References: Barnes CJ, Gastroenterology 1998 May;114(5):873-7 |
||||
Intestine - Small Intestine - Duodenum adenoma | Intestine - Small Intestine - Duodenum | piroxicam |
observed |
References: Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
||||
Intestine - Small Intestine - Duodenum adenoma | Intestine - Small Intestine - Duodenum | N-[4-(3-chloro-4-fluoro-phenylamino)-quinazolin-6-yl]acrylamide (CFPQA) |
observed |
References: Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
||||
Intestine - Small Intestine - Duodenum adenoma | Intestine - Small Intestine - Duodenum |
observed |
References: Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
|||||
Intestine - Small Intestine - Duodenum lesion | Intestine - Small Intestine - Duodenum | N-[4-(3-chloro-4-fluoro-phenylamino)-quinazolin-6-yl]acrylamide (CFPQA) |
0 - observed |
References: Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
||||
Intestine - Small Intestine - Duodenum polyp | Intestine - Small Intestine - Duodenum | polyethylene glycol |
observed |
References: Shailubhai K, Cancer Res 2000 Sep 15;60(18):5151-7 |
||||
Intestine - Small Intestine - Duodenum polyp | Intestine - Small Intestine - Duodenum | uroguanylin ⋅ polyethylene glycol |
observed |
References: Shailubhai K, Cancer Res 2000 Sep 15;60(18):5151-7 |
||||
Intestine - Small Intestine - Duodenum polyp | Intestine - Small Intestine - Duodenum |
45.45 |
References: Zeineldin M, Oncogene 2012 May 10;31(19):2423-37 |
|||||
Intestine - Small Intestine - Duodenum tumor | Intestine - Small Intestine - Duodenum |
observed |
observed |
References: Boolbol SK, Cancer Res 1996 Jun 1;56(11):2556-60 ⋅ Mahmoud NN, Carcinogenesis 1999 Feb;20(2):299-303 ⋅ Sun X, Mol Cancer 2009;8():73 ⋅ Weyant MJ, Cancer Res 2001 Jan 1;61(1):118-25 ⋅ Weyant MJ, Cancer Res 2001 Mar 15;61(6):2547-51 |
||||
Intestine - Small Intestine - Duodenum tumor | Intestine - Small Intestine - Duodenum | chenodeoxycholate (chenodeoxycholic acid) |
observed |
References: Mahmoud NN, Carcinogenesis 1999 Feb;20(2):299-303 |
||||
Intestine - Small Intestine - Duodenum tumor | Intestine - Small Intestine - Duodenum | sulindac |
0 |
References: Boolbol SK, Cancer Res 1996 Jun 1;56(11):2556-60 |
||||
Intestine - Small Intestine - Duodenum tumor | Intestine - Small Intestine - Duodenum | polyethylene glycol |
30 |
References: Shailubhai K, Cancer Res 2000 Sep 15;60(18):5151-7 |
||||
Intestine - Small Intestine - Duodenum tumor | Intestine - Small Intestine - Duodenum | (+)-catechin |
observed |
References: Weyant MJ, Cancer Res 2001 Jan 1;61(1):118-25 |
||||
Intestine - Small Intestine - Duodenum tumor | Intestine - Small Intestine - Duodenum | ovariectomy |
observed |
References: Weyant MJ, Cancer Res 2001 Mar 15;61(6):2547-51 |
||||
Intestine - Small Intestine - Duodenum tumor | Intestine - Small Intestine - Duodenum | 17beta-estradiol (E2) ⋅ ovariectomy |
observed |
References: Weyant MJ, Cancer Res 2001 Mar 15;61(6):2547-51 |
||||
Intestine - Small Intestine - Ileum adenoma | Intestine - Small Intestine - Ileum |
observed |
observed |
References: Paoni NF, Physiol Genomics 2003 Nov 11;15(3):228-35 ⋅ Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
||||
Intestine - Small Intestine - Ileum adenoma | Intestine - Small Intestine - Ileum | N-[4-(3-chloro-4-fluoro-phenylamino)-quinazolin-6-yl]acrylamide (CFPQA) |
observed |
References: Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
||||
Intestine - Small Intestine - Ileum adenoma | Intestine - Small Intestine - Ileum | piroxicam |
observed |
References: Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
||||
Intestine - Small Intestine - Ileum carcinoma | Intestine - Small Intestine - Ileum |
observed |
References: Paoni NF, Physiol Genomics 2003 Nov 11;15(3):228-35 |
|||||
Intestine - Small Intestine - Ileum polyp | Intestine - Small Intestine - Ileum | uroguanylin ⋅ polyethylene glycol |
observed |
References: Shailubhai K, Cancer Res 2000 Sep 15;60(18):5151-7 |
||||
Intestine - Small Intestine - Ileum polyp | Intestine - Small Intestine - Ileum | polyethylene glycol |
observed |
References: Shailubhai K, Cancer Res 2000 Sep 15;60(18):5151-7 |
||||
Intestine - Small Intestine - Ileum polyp | Intestine - Small Intestine - Ileum |
100 |
References: Zeineldin M, Oncogene 2012 May 10;31(19):2423-37 |
|||||
Intestine - Small Intestine - Ileum tumor | Intestine - Small Intestine - Ileum |
observed |
observed |
References: Boolbol SK, Cancer Res 1996 Jun 1;56(11):2556-60 ⋅ Sun X, Mol Cancer 2009;8():73 |
||||
Intestine - Small Intestine - Ileum tumor | Intestine - Small Intestine - Ileum | sulindac |
0 |
References: Boolbol SK, Cancer Res 1996 Jun 1;56(11):2556-60 |
||||
Intestine - Small Intestine - Jejunum adenoma | Intestine - Small Intestine - Jejunum |
observed |
References: Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
|||||
Intestine - Small Intestine - Jejunum adenoma | Intestine - Small Intestine - Jejunum | N-[4-(3-chloro-4-fluoro-phenylamino)-quinazolin-6-yl]acrylamide (CFPQA) |
observed |
References: Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
||||
Intestine - Small Intestine - Jejunum adenoma | Intestine - Small Intestine - Jejunum | piroxicam |
observed |
References: Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
||||
Intestine - Small Intestine - Jejunum polyp | Intestine - Small Intestine - Jejunum | uroguanylin ⋅ polyethylene glycol |
observed |
References: Shailubhai K, Cancer Res 2000 Sep 15;60(18):5151-7 |
||||
Intestine - Small Intestine - Jejunum polyp | Intestine - Small Intestine - Jejunum | polyethylene glycol |
observed |
References: Shailubhai K, Cancer Res 2000 Sep 15;60(18):5151-7 |
||||
Intestine - Small Intestine - Jejunum polyp | Intestine - Small Intestine - Jejunum |
100 |
References: Zeineldin M, Oncogene 2012 May 10;31(19):2423-37 |
|||||
Intestine - Small Intestine - Jejunum tumor | Intestine - Small Intestine - Jejunum |
observed |
observed |
References: Boolbol SK, Cancer Res 1996 Jun 1;56(11):2556-60 ⋅ Sun X, Mol Cancer 2009;8():73 |
||||
Intestine - Small Intestine - Jejunum tumor | Intestine - Small Intestine - Jejunum | sulindac |
0 |
References: Boolbol SK, Cancer Res 1996 Jun 1;56(11):2556-60 |
||||
Intestine - Small Intestine - Medial adenoma | Intestine - Small Intestine - Medial |
observed |
observed |
References: Nakatsugi S, Jpn J Cancer Res 1997 Dec;88(12):1117-20 ⋅ Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Small Intestine - Medial adenoma | Intestine - Small Intestine - Medial | ceramide (N-palmitoylsphingosine) |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Small Intestine - Medial adenoma | Intestine - Small Intestine - Medial | sphingolipid mix |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Small Intestine - Medial adenoma | Intestine - Small Intestine - Medial | sphingolipid mix ⋅ ceramide (N-palmitoylsphingosine) |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Small Intestine - Medial adenoma | Intestine - Small Intestine - Medial | nimesulide (4-nitro-2-phenoxymethanesulfonanilide) |
observed |
References: Nakatsugi S, Jpn J Cancer Res 1997 Dec;88(12):1117-20 |
||||
Intestine - Small Intestine - Medial polyp | Intestine - Small Intestine - Medial |
observed |
References: Mutoh M, Cancer Res 2002 Jan 1;62(1):28-32 |
|||||
Intestine - Small Intestine - Medial polyp | Intestine - Small Intestine - Medial | 2-[2-{2-(1-naphthyl)propanoylamino}phenyl]methylbenzoic acid (ONO-AE2-227) |
observed |
References: Mutoh M, Cancer Res 2002 Jan 1;62(1):28-32 |
||||
Intestine - Small Intestine - Medial tumor | Intestine - Small Intestine - Medial | 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) |
observed |
References: Steffensen IL, Cancer Res 2001 Dec 15;61(24):8689-96 |
||||
Intestine - Small Intestine - Medial tumor | Intestine - Small Intestine - Medial |
observed |
observed |
observed |
References: Barnes CJ, Gastroenterology 1998 May;114(5):873-7 ⋅ Xie G, JCI Insight 2022 Feb 22;7(4):e150894 |
|||
Intestine - Small Intestine - Medial tumor | Intestine - Small Intestine - Medial | aspirin (acetylsalicylic acid) (ASA) |
observed |
References: Barnes CJ, Gastroenterology 1998 May;114(5):873-7 |
||||
Intestine - Small Intestine - Proximal adenoma | Intestine - Small Intestine - Proximal |
observed |
observed - 100 |
References: Nakatsugi S, Jpn J Cancer Res 1997 Dec;88(12):1117-20 ⋅ Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 ⋅ Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Small Intestine - Proximal adenoma | Intestine - Small Intestine - Proximal | ceramide (N-palmitoylsphingosine) |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Small Intestine - Proximal adenoma | Intestine - Small Intestine - Proximal | sphingolipid mix |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Small Intestine - Proximal adenoma | Intestine - Small Intestine - Proximal | sphingolipid mix ⋅ ceramide (N-palmitoylsphingosine) |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine - Small Intestine - Proximal adenoma | Intestine - Small Intestine - Proximal | NID525, PPAR gamma agonist |
100 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Small Intestine - Proximal adenoma | Intestine - Small Intestine - Proximal | nimesulide (4-nitro-2-phenoxymethanesulfonanilide) |
observed |
References: Nakatsugi S, Jpn J Cancer Res 1997 Dec;88(12):1117-20 |
||||
Intestine - Small Intestine - Proximal polyp | Intestine - Small Intestine - Proximal |
observed |
References: Mutoh M, Cancer Res 2002 Jan 1;62(1):28-32 |
|||||
Intestine - Small Intestine - Proximal polyp | Intestine - Small Intestine - Proximal | 2-[2-{2-(1-naphthyl)propanoylamino}phenyl]methylbenzoic acid (ONO-AE2-227) |
observed |
References: Mutoh M, Cancer Res 2002 Jan 1;62(1):28-32 |
||||
Intestine - Small Intestine - Proximal tumor | Intestine - Small Intestine - Proximal | 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) |
observed |
References: Steffensen IL, Cancer Res 2001 Dec 15;61(24):8689-96 |
||||
Intestine - Small Intestine - Proximal tumor | Intestine - Small Intestine - Proximal | BRL-49,653, PPAR gamma ligand |
observed |
References: Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 |
||||
Intestine - Small Intestine - Proximal tumor | Intestine - Small Intestine - Proximal |
observed |
observed |
observed |
References: Barnes CJ, Gastroenterology 1998 May;114(5):873-7 ⋅ Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 ⋅ Xie G, JCI Insight 2022 Feb 22;7(4):e150894 |
|||
Intestine - Small Intestine - Proximal tumor | Intestine - Small Intestine - Proximal | troglitazone |
observed - 100 |
References: Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 ⋅ Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Small Intestine - Proximal tumor | Intestine - Small Intestine - Proximal | pioglitazone |
100 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Small Intestine - Proximal tumor | Intestine - Small Intestine - Proximal | rosiglitazone |
100 |
References: Pino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63 |
||||
Intestine - Small Intestine - Proximal tumor | Intestine - Small Intestine - Proximal | aspirin (acetylsalicylic acid) (ASA) |
observed |
References: Barnes CJ, Gastroenterology 1998 May;114(5):873-7 |
||||
Intestine - Small Intestine adenoma | Intestine - Small Intestine |
observed - 100 |
very high - 100 |
observed - 100 |
observed - 94.74 |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): ⋅ Chen Q, Life Sci Alliance 2021 Mar;4(3): ⋅ Paulsen JE, Carcinogenesis 1997 Oct;18(10):1905-10 ⋅ Qi C, Int J Biol Sci 2015;11(6):679-87 ⋅ Shattuck-Brandt RL, Mol Carcinog 1999 Mar;24(3):177-87 ⋅ Steffensen IL, Carcinogenesis 1997 May;18(5):1049-54 ⋅ Weyant MJ, Cancer Res 2001 Mar 15;61(6):2547-51 ⋅ Wilson CL, Proc Natl Acad Sci U S A 1997 Feb 18;94(4):1402-7 ⋅ Woo DK, Am J Pathol 2012 Jan;180(1):24-31 ⋅ Xie G, JCI Insight 2022 Feb 22;7(4):e150894 ⋅ Zheng W, Int J Cancer 2012 Jan 1;130(1):10-9 2 pathology image(s) |
||
Intestine - Small Intestine adenoma | Intestine - Small Intestine | 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) |
100 |
100 |
References: Steffensen IL, Carcinogenesis 1997 May;18(5):1049-54 |
|||
Intestine - Small Intestine adenoma | Intestine - Small Intestine | fish oil |
very high |
very high |
References: Paulsen JE, Carcinogenesis 1997 Oct;18(10):1905-10 |
|||
Intestine - Small Intestine adenoma | Intestine - Small Intestine | ovariectomy |
observed |
References: Weyant MJ, Cancer Res 2001 Mar 15;61(6):2547-51 |
||||
Intestine - Small Intestine adenoma | Intestine - Small Intestine | 17beta-estradiol (E2) ⋅ ovariectomy |
observed |
References: Weyant MJ, Cancer Res 2001 Mar 15;61(6):2547-51 |
||||
Intestine - Small Intestine adenoma - microadenoma | Intestine - Small Intestine |
observed |
References: Qi C, Int J Biol Sci 2015;11(6):679-87 |
|||||
Intestine - Small Intestine dysplasia | Intestine - Small Intestine |
observed |
References: Dudley ME, Int J Cancer 1996 Jan 17;65(2):249-53 |
|||||
Intestine - Small Intestine dysplasia - high grade | Intestine - Small Intestine |
5.26 |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): |
|||||
Intestine - Small Intestine dysplasia - low grade | Intestine - Small Intestine |
94.74 |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): |
|||||
Intestine - Small Intestine lesion | Intestine - Small Intestine |
observed |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): |
|||||
Intestine - Small Intestine lesion - malignant | Intestine - Small Intestine |
0 |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): |
|||||
Intestine - Small Intestine polyp | Intestine - Small Intestine |
very high |
observed - 100 |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): ⋅ Dudley ME, Int J Cancer 1996 Jan 17;65(2):249-53 ⋅ Gupta RA, Nat Med 2004 Mar;10(3):245-7 ⋅ Zeineldin M, Oncogene 2012 May 10;31(19):2423-37 |
||||
Intestine - Small Intestine polyp | Intestine - Small Intestine | GW501516, PPAR-delta agonist |
observed |
References: Gupta RA, Nat Med 2004 Mar;10(3):245-7 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | low fiber |
100 |
References: Pierre F, Cancer Res 1997 Jan 15;57(2):225-8 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | high fiber |
100 |
References: Pierre F, Cancer Res 1997 Jan 15;57(2):225-8 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine |
observed |
observed |
observed - 100 |
observed - 100 |
References: Hansen-Petrik MB, Cancer Res 2002 Jan 15;62(2):403-8 ⋅ Ma H, Cell Rep 2020 Jan 21;30(3):793-806.e6 ⋅ Mahmoud NN, Carcinogenesis 1999 Feb;20(2):299-303 ⋅ Qi C, Int J Biol Sci 2015;11(6):679-87 ⋅ Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 ⋅ Steffensen IL, Cancer Res 2001 Dec 15;61(24):8689-96 ⋅ Sun X, Mol Cancer 2009;8():73 ⋅ Ton-That H, FEBS Lett 1997 Dec 15;419(2-3):239-43 ⋅ Weyant MJ, Cancer Res 2001 Jan 1;61(1):118-25 ⋅ Williams JL, Biochem Biophys Res Commun 2004 Jan 16;313(3):784-8 ⋅ Xie G, JCI Insight 2022 Feb 22;7(4):e150894 ⋅ You S, Cancer Cell 2024 Aug 12;42(8):1415-1433.e12 ⋅ Ziegler CC, J Nutr 2004 Jan;134(1):5-10 |
||
Intestine - Small Intestine tumor | Intestine - Small Intestine | chenodeoxycholate (chenodeoxycholic acid) |
observed |
References: Mahmoud NN, Carcinogenesis 1999 Feb;20(2):299-303 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | sulfasalazine (SASP) |
observed |
References: Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | Pentasa |
observed |
References: Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | 5-aminosalicylic acid, free acid (5-ASA) |
observed |
References: Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | (+)-catechin |
observed |
References: Weyant MJ, Cancer Res 2001 Jan 1;61(1):118-25 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | piroxicam |
observed |
References: Hansen-Petrik MB, Cancer Res 2002 Jan 15;62(2):403-8 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | 16,16-dimethyl-prostaglandin E2 (16,16dmPGE2) ⋅ 17-phenyl-trinor-prostaglandin E2 |
observed |
References: Hansen-Petrik MB, Cancer Res 2002 Jan 15;62(2):403-8 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | 16,16-dimethyl-prostaglandin E2 (16,16dmPGE2) ⋅ piroxicam ⋅ 17-phenyl-trinor-prostaglandin E2 |
observed |
References: Hansen-Petrik MB, Cancer Res 2002 Jan 15;62(2):403-8 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | anti-prostaglandin E2 (PGE2monoclonal antibody 2B5) |
observed |
References: Hansen-Petrik MB, Cancer Res 2002 Jan 15;62(2):403-8 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | 17-phenyl-trinor-prostaglandin E2 |
observed |
References: Hansen-Petrik MB, Cancer Res 2002 Jan 15;62(2):403-8 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | piroxicam ⋅ 17-phenyl-trinor-prostaglandin E2 |
observed |
References: Hansen-Petrik MB, Cancer Res 2002 Jan 15;62(2):403-8 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | sulindac |
observed |
References: Hansen-Petrik MB, Cancer Res 2002 Jan 15;62(2):403-8 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | 16,16-dimethyl-prostaglandin E2 (16,16dmPGE2) ⋅ sulindac ⋅ 17-phenyl-trinor-prostaglandin E2 |
observed |
References: Hansen-Petrik MB, Cancer Res 2002 Jan 15;62(2):403-8 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) |
observed - 100 |
References: Steffensen IL, Cancer Res 2001 Dec 15;61(24):8689-96 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | resveratrol |
observed |
References: Ziegler CC, J Nutr 2004 Jan;134(1):5-10 |
||||
Intestine - Small Intestine tumor | Intestine - Small Intestine | 2-(acetyloxy)benzoic acid 4-(nitrooxy methyl)phenyl ester) (NO-ASA) |
90 |
References: Williams JL, Biochem Biophys Res Commun 2004 Jan 16;313(3):784-8 |
||||
Intestine adenocarcinoma | Intestine |
observed |
References: Sun X, Mol Cancer 2009;8():73 |
|||||
Intestine adenoma | Intestine | high saturated fat |
very high |
References: Wechter WJ, Cancer Res 1997 Oct 1;57(19):4316-24 |
||||
Intestine adenoma | Intestine | low saturated fat |
very high |
References: Wechter WJ, Cancer Res 1997 Oct 1;57(19):4316-24 |
||||
Intestine adenoma | Intestine | high saturated fat ⋅ R-flurbiprofen (R-FB) (E-7869) |
very high |
References: Wechter WJ, Cancer Res 1997 Oct 1;57(19):4316-24 |
||||
Intestine adenoma | Intestine | low saturated fat ⋅ R-flurbiprofen (R-FB) (E-7869) |
very high |
References: Wechter WJ, Cancer Res 1997 Oct 1;57(19):4316-24 |
||||
Intestine adenoma | Intestine |
0 - 100 |
observed |
observed |
observed |
References: Boolbol SK, Cancer Res 1996 Jun 1;56(11):2556-60 ⋅ Chen Q, Life Sci Alliance 2021 Mar;4(3): ⋅ Goss KJ, Int J Cancer 1998 Nov 23;78(5):629-35 ⋅ Guillen-Ahlers H, Carcinogenesis 2008 Jul;29(7):1421-7 ⋅ Gutierrez LS, Carcinogenesis 2003 Feb;24(2):199-207 ⋅ He XY, Cell Rep 2015 Nov 3;13(5):888-97 ⋅ Heuberger J, Life Sci Alliance 2019 Feb;2(1):e201800173 ⋅ Mahmoud NN, Carcinogenesis 1998 Jan;19(1):87-91 ⋅ Mahmoud NN, Carcinogenesis 2000 May;21(5):921-7 ⋅ Maywald RL, Proc Natl Acad Sci U S A 2015 May 12;112(19):E2487-96 ⋅ Nakatsugi S, Jpn J Cancer Res 1997 Dec;88(12):1117-20 ⋅ Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 ⋅ Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 ⋅ Steinbrecher KA, Biochem Biophys Res Commun 2000 Jun 24;273(1):225-30 ⋅ Thompson JA, Int J Cancer 1997 Jul 3;72(1):197-202 ⋅ Wagenaar-Miller RA, Br J Cancer 2003 May 6;88(9):1445-52 ⋅ Weyant MJ, Cancer Res 2001 Jan 1;61(1):118-25 ⋅ Weyant MJ, Cancer Res 2001 Mar 15;61(6):2547-51 ⋅ Yamada T, Cancer Res 2003 Mar 1;63(5):895-901 ⋅ Zheng W, Int J Cancer 2012 Jan 1;130(1):10-9 |
||
Intestine adenoma | Intestine | sulindac sulfide |
30 |
References: Mahmoud NN, Carcinogenesis 1998 Jan;19(1):87-91 |
||||
Intestine adenoma | Intestine | sulindac sulfone |
100 |
References: Mahmoud NN, Carcinogenesis 1998 Jan;19(1):87-91 |
||||
Intestine adenoma | Intestine | caffeic acid phenethyl ester (CAPE) |
very high |
References: Mahmoud NN, Carcinogenesis 2000 May;21(5):921-7 |
||||
Intestine adenoma | Intestine | curcumin |
very high |
References: Mahmoud NN, Carcinogenesis 2000 May;21(5):921-7 |
||||
Intestine adenoma | Intestine | quercetin |
very high |
References: Mahmoud NN, Carcinogenesis 2000 May;21(5):921-7 |
||||
Intestine adenoma | Intestine | rutin |
very high |
References: Mahmoud NN, Carcinogenesis 2000 May;21(5):921-7 |
||||
Intestine adenoma | Intestine | N-[4-(3-chloro-4-fluoro-phenylamino)-quinazolin-6-yl]acrylamide (CFPQA) |
observed |
References: Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
||||
Intestine adenoma | Intestine | (+)-catechin |
observed |
References: Weyant MJ, Cancer Res 2001 Jan 1;61(1):118-25 |
||||
Intestine adenoma | Intestine | ceramide (N-palmitoylsphingosine) |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine adenoma | Intestine | sphingolipid mix |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine adenoma | Intestine | sphingolipid mix ⋅ ceramide (N-palmitoylsphingosine) |
observed |
References: Schmelz EM, Cancer Res 2001 Sep 15;61(18):6723-9 |
||||
Intestine adenoma | Intestine | piroxicam |
observed |
References: Ritland SR, Cancer Res 2000 Sep 1;60(17):4678-81 |
||||
Intestine adenoma | Intestine | ovariectomy |
observed |
References: Weyant MJ, Cancer Res 2001 Mar 15;61(6):2547-51 |
||||
Intestine adenoma | Intestine | 17beta-estradiol (E2) ⋅ ovariectomy |
observed |
References: Weyant MJ, Cancer Res 2001 Mar 15;61(6):2547-51 |
||||
Intestine adenoma | Intestine | A-177430, MMP inhibitor |
observed |
References: Wagenaar-Miller RA, Br J Cancer 2003 May 6;88(9):1445-52 |
||||
Intestine adenoma | Intestine | A-285969, Cox-2 inhibitor |
observed |
References: Wagenaar-Miller RA, Br J Cancer 2003 May 6;88(9):1445-52 |
||||
Intestine adenoma | Intestine | sulindac |
observed |
observed |
References: Guillen-Ahlers H, Carcinogenesis 2008 Jul;29(7):1421-7 ⋅ Wagenaar-Miller RA, Br J Cancer 2003 May 6;88(9):1445-52 |
|||
Intestine adenoma | Intestine | A-177430, MMP inhibitor ⋅ A-285969, Cox-2 inhibitor |
observed |
References: Wagenaar-Miller RA, Br J Cancer 2003 May 6;88(9):1445-52 |
||||
Intestine adenoma | Intestine | nimesulide (4-nitro-2-phenoxymethanesulfonanilide) |
observed |
References: Nakatsugi S, Jpn J Cancer Res 1997 Dec;88(12):1117-20 |
||||
Intestine adenoma | Intestine | batimastat (BB-94) |
observed |
References: Goss KJ, Int J Cancer 1998 Nov 23;78(5):629-35 |
||||
Intestine adenoma | Intestine | low saturated fat ⋅ S-flurbiprofen (S-FB) |
very high |
References: Wechter WJ, Cancer Res 1997 Oct 1;57(19):4316-24 |
||||
Intestine lesion | Intestine |
observed |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): |
|||||
Intestine polyp | Intestine | uroguanylin ⋅ polyethylene glycol |
observed |
References: Shailubhai K, Cancer Res 2000 Sep 15;60(18):5151-7 |
||||
Intestine polyp | Intestine | polyethylene glycol |
observed |
References: Shailubhai K, Cancer Res 2000 Sep 15;60(18):5151-7 |
||||
Intestine polyp | Intestine |
observed |
observed - 100 |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): ⋅ He XY, Cell Rep 2015 Nov 3;13(5):888-97 ⋅ Heuberger J, Life Sci Alliance 2019 Feb;2(1):e201800173 ⋅ Maywald RL, Proc Natl Acad Sci U S A 2015 May 12;112(19):E2487-96 ⋅ Mutoh M, Cancer Res 2002 Jan 1;62(1):28-32 ⋅ Qi C, Int J Biol Sci 2015;11(6):679-87 ⋅ Wang X, Oncogene 2017 Aug 31;36(35):4987-4996 |
||||
Intestine polyp | Intestine | 2-[2-{2-(1-naphthyl)propanoylamino}phenyl]methylbenzoic acid (ONO-AE2-227) |
observed |
References: Mutoh M, Cancer Res 2002 Jan 1;62(1):28-32 |
||||
Intestine polyp | Intestine | anti-IL1RL1 (mu-IgG1-FC?anti-muST2, Amgen) |
observed |
References: Maywald RL, Proc Natl Acad Sci U S A 2015 May 12;112(19):E2487-96 |
||||
Intestine polyp | Intestine | anti-IgG (4D2-mu-IgG1?anti-huAGP3-Pb, Amgen) |
observed |
References: Maywald RL, Proc Natl Acad Sci U S A 2015 May 12;112(19):E2487-96 |
||||
Intestine polyp - adenomatous | Intestine |
observed |
References: Maywald RL, Proc Natl Acad Sci U S A 2015 May 12;112(19):E2487-96 ⋅ Zheng W, Int J Cancer 2012 Jan 1;130(1):10-9 |
|||||
Intestine tumor | Intestine |
observed - 100 |
observed |
observed |
observed - 100 |
References: Andrijes R, Proc Natl Acad Sci U S A 2021 Sep 28;118(39): ⋅ Barnes CJ, Gastroenterology 1998 May;114(5):873-7 ⋅ Boolbol SK, Cancer Res 1996 Jun 1;56(11):2556-60 ⋅ Dudley ME, Int J Cancer 1996 Jan 17;65(2):249-53 ⋅ Heuberger J, Life Sci Alliance 2019 Feb;2(1):e201800173 ⋅ Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 ⋅ Maywald RL, Proc Natl Acad Sci U S A 2015 May 12;112(19):E2487-96 ⋅ Moser AR, Cancer Res 2001 Apr 15;61(8):3480-5 ⋅ Oster H, Cancer Res 2006 Jul 15;66(14):6955-63 ⋅ Qi C, Int J Biol Sci 2015;11(6):679-87 ⋅ Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 ⋅ Wang X, Oncogene 2017 Aug 31;36(35):4987-4996 ⋅ Wilson CL, Proc Natl Acad Sci U S A 1997 Feb 18;94(4):1402-7 ⋅ You S, Cancer Cell 2024 Aug 12;42(8):1415-1433.e12 ⋅ Zheng W, Int J Cancer 2012 Jan 1;130(1):10-9 |
||
Intestine tumor | Intestine | piroxicam |
observed |
References: Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 |
||||
Intestine tumor | Intestine | sulindac |
10 |
observed |
References: Boolbol SK, Cancer Res 1996 Jun 1;56(11):2556-60 ⋅ Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 |
|||
Intestine tumor | Intestine | 5-aminosalicylic acid, free acid (5-ASA) |
observed |
References: Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 |
||||
Intestine tumor | Intestine | 4-aminosalicylic acid, sodium salt (4-ASA) |
observed |
References: Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 |
||||
Intestine tumor | Intestine | Pentasa |
observed |
References: Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 |
||||
Intestine tumor | Intestine | sulfasalazine (SASP) |
observed |
References: Ritland SR, Clin Cancer Res 1999 Apr;5(4):855-63 |
||||
Intestine tumor | Intestine | BRL-49,653, PPAR gamma ligand |
observed |
References: Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 |
||||
Intestine tumor | Intestine | troglitazone |
observed |
References: Lefebvre AM, Nat Med 1998 Sep;4(9):1053-7 |
||||
Intestine tumor | Intestine | aspirin (acetylsalicylic acid) (ASA) |
observed |
References: Barnes CJ, Gastroenterology 1998 May;114(5):873-7 |
||||
Intestine tumor | Intestine | anti-IL1RL1 (mu-IgG1-FC?anti-muST2, Amgen) |
observed |
References: Maywald RL, Proc Natl Acad Sci U S A 2015 May 12;112(19):E2487-96 |
||||
Intestine tumor | Intestine | anti-IgG (4D2-mu-IgG1?anti-huAGP3-Pb, Amgen) |
observed |
References: Maywald RL, Proc Natl Acad Sci U S A 2015 May 12;112(19):E2487-96 |
||||
Intestine tumor | Intestine | tamoxifen (for inducing expression from mutant alleles) |
observed |
References: Powell AE, Am J Physiol Gastrointest Liver Physiol 2014 Jul 1;307(1):G16-23 |
||||
Intestine tumor | Intestine | anti-mouse MHC Class II (M5/115.15.2) |
observed |
References: You S, Cancer Cell 2024 Aug 12;42(8):1415-1433.e12 |
||||
Intestine tumor - epithelial | Intestine |
observed |
References: Wang X, Oncogene 2017 Aug 31;36(35):4987-4996 |
|||||
Stomach polyp | Stomach |
45.45 |
References: Zeineldin M, Oncogene 2012 May 10;31(19):2423-37 |