Reference SummaryThompson JA, Int J Cancer 1997 Jul 3;72(1):197-202
Title |
Expression of transgenic carcinoembryonic antigen (CEA) in tumor-prone mice: an animal model for CEA-directed tumor immunotherapy. | ||||||||||||||||
Authors |
Thompson JA; Eades-Perner AM; Ditter M; Muller WJ; Zimmermann W | ||||||||||||||||
Journal |
Int J Cancer | ||||||||||||||||
Volume |
72 | ||||||||||||||||
Issue |
1 | ||||||||||||||||
Year |
1997 | ||||||||||||||||
Pages |
197-202 | ||||||||||||||||
Abstract |
Carcinoembryonic antigen (CEA) is a tumor marker for the most common forms of adenocarcinomas, We have previously described C57BL/6 mice transgenic for the complete human CEA gene, Compared with humans, these mice reveal a conserved spatiotemporal CEA expression pattern, To establish animal models for CEA-targeted tumor immunotherapy, we have crossed CEA transgenic mice with mice that are genetically predisposed to tumor development, These immunocompetent animals should allow optimization of immunotherapy strategies for maximal destruction of tumor tissues with minimal damage to CEA- expressing normal tissues, To develop a breast tumor model, CEA transgenic mice were cross-bred with mice transgenic for the rat neo protooncogene controlled by the mouse mammary tumor virus long terminal repeat, Female offspring developed poorly differentiated breast tumors, none of which, however, expressed CEA, As a model for colorectal tumors, mice bearing a mutation in the Ape gene (Min mice) and the CEA transgene developed multiple intestinal adenomas with strong CEA expression in all tumor cells, CEA expression had no significant effect on tumor growth, Occasional, well-differentiated breast adenocarcinomas in female offspring expressed CEA focally in tumor cells lining pseudolumina, Cross-breeding Apc(Min/+) mice with neu transgenic mice did not reveal a synergistic effect on the kinetics of breast tumor formation, Finally, CEA transgenic mice crossbred with mice transgenic for the SV40 large T antigen regulated by the surfactant protein-C promoter, developed multiple lung adenocavcinomas that revealed a mosaic CEA expression pattern. (C) 1997 Wiley-Liss, Inc. | ||||||||||||||||
Links |
J:41380 – MGI References 9212243 – National Library of Medicine/PubMed |
||||||||||||||||
Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
STOCK ApcMin/+ Tg(CEACAM5)#Wzm | Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon |
observed |
||
STOCK ApcMin/+ | Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon |
observed |
||
STOCK Tg(CEACAM5)#Wzm | Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon |
0 |
||
STOCK | Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon |
0 |
||
STOCK ApcMin/+ Tg(CEACAM5)#Wzm | Intestine - Small Intestine adenoma | Intestine - Small Intestine |
observed |
||
STOCK ApcMin/+ | Intestine - Small Intestine adenoma | Intestine - Small Intestine |
observed |
||
STOCK Tg(CEACAM5)#Wzm | Intestine - Small Intestine adenoma | Intestine - Small Intestine |
0 |
||
STOCK | Intestine - Small Intestine adenoma | Intestine - Small Intestine |
0 |
||
STOCK ApcMin/+ Tg(CEACAM5)#Wzm Tg(MMTVneu)202Mul | Intestine adenoma | Intestine |
observed |
||
C57BL/6J-ApcMin/+ | Intestine adenoma | Intestine |
observed |
||
STOCK Tg(CEACAM5)#Wzm Tg(SFTPC-TAg)5.1Jaw | Lung adenocarcinoma | Lung |
observed |
||
STOCK Tg(CEACAM5)#Wzm Tg(SFTPC-TAg)5.1Jaw | Lung adenoma | Lung |
observed |
||
STOCK Tg(SFTPC-TAg)5.1Jaw | Lung adenoma | Lung |
observed |
||
STOCK Tg(CEACAM5)#Wzm Tg(SFTPC-TAg)5.1Jaw | Lung hyperplasia | Lung |
observed |
||
STOCK ApcMin/+ | Mammary gland adenoma | Mammary gland |
observed |
||
STOCK ApcMin/+ Tg(CEACAM5)#Wzm | Mammary gland tumor | Mammary gland |
18 |
||
STOCK Tg(CEACAM5)#Wzm Tg(MMTVneu)202Mul | Mammary gland tumor | Mammary gland |
observed |
||
STOCK ApcMin/+ Tg(CEACAM5)#Wzm Tg(MMTVneu)202Mul | Mammary gland tumor | Mammary gland |
observed |