Reference SummaryNakatsugi S, Jpn J Cancer Res 1997 Dec;88(12):1117-20

Title

Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice

Authors

Nakatsugi S; Fukutake M; Takahashi M; Fukuda K; Isoi T; Taniguchi Y; Sugimura T; Wakabayashi K

Journal

Jpn J Cancer Res

Volume

Issue

Year

1997

Pages

1117-20

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) suppress colon carcinogenesis in man and experimental animals. However, conventional NSAIDs inhibit both cyclooxygenase (COX) isoforms, COX-1 and COX-2, and cause gastrointestinal side-effects. Nimesulide, a selective inhibitor of COX-2, is much less ulcerogenic. We, therefore, examined its influence on the development of intestinal polyps in Min mice. Female Min mice at 4 weeks old were given 400 ppm nimesulide in their diet for 11 weeks. This treatment resulted in a significant reduction of the numbers of both small and large intestinal polyps, the total being 52% of that in untreated control Min mice. The size of the polyps in the nimesulide-treated group was also significantly decreased. The results suggest that nimesulide is a good candidate as a chemopreventive agent for human colon cancer with low toxicity.

Links

J:45606 – MGI References
9473726 – National Library of Medicine/PubMed

Strain Notes

Strain	Note
C57BL/6J-Apc^Min/+	Mice were obtained from The Jackson Laboratory at 4 weeks of age. 'Nimesulide treatment caused no significant changes in other organs such as the liver, lung, spleen, and kidney.'

Models
Strain	Model Name	Treatment Agent(s)	Organ Affected	Frequency
C57BL/6J-Apc^Min/+	Intestine - Large Intestine adenoma		Intestine - Large Intestine	observed
C57BL/6J-Apc^Min/+	Intestine - Large Intestine adenoma	nimesulide (4-nitro-2-phenoxymethanesulfonanilide)	Intestine - Large Intestine	observed
C57BL/6J-Apc^Min/+	Intestine - Small Intestine - Distal adenoma		Intestine - Small Intestine - Distal	observed
C57BL/6J-Apc^Min/+	Intestine - Small Intestine - Distal adenoma	nimesulide (4-nitro-2-phenoxymethanesulfonanilide)	Intestine - Small Intestine - Distal	observed
C57BL/6J-Apc^Min/+	Intestine - Small Intestine - Medial adenoma		Intestine - Small Intestine - Medial	observed
C57BL/6J-Apc^Min/+	Intestine - Small Intestine - Medial adenoma	nimesulide (4-nitro-2-phenoxymethanesulfonanilide)	Intestine - Small Intestine - Medial	observed
C57BL/6J-Apc^Min/+	Intestine - Small Intestine - Proximal adenoma		Intestine - Small Intestine - Proximal	observed
C57BL/6J-Apc^Min/+	Intestine - Small Intestine - Proximal adenoma	nimesulide (4-nitro-2-phenoxymethanesulfonanilide)	Intestine - Small Intestine - Proximal	observed
C57BL/6J-Apc^Min/+	Intestine adenoma		Intestine	observed
C57BL/6J-Apc^Min/+	Intestine adenoma	nimesulide (4-nitro-2-phenoxymethanesulfonanilide)	Intestine	observed