Reference SummaryNakatsugi S, Jpn J Cancer Res 1997 Dec;88(12):1117-20
Title |
Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice | ||||
Authors |
Nakatsugi S; Fukutake M; Takahashi M; Fukuda K; Isoi T; Taniguchi Y; Sugimura T; Wakabayashi K | ||||
Journal |
Jpn J Cancer Res | ||||
Volume |
88 | ||||
Issue |
12 | ||||
Year |
1997 | ||||
Pages |
1117-20 | ||||
Abstract |
Nonsteroidal anti-inflammatory drugs (NSAIDs) suppress colon carcinogenesis in man and experimental animals. However, conventional NSAIDs inhibit both cyclooxygenase (COX) isoforms, COX-1 and COX-2, and cause gastrointestinal side-effects. Nimesulide, a selective inhibitor of COX-2, is much less ulcerogenic. We, therefore, examined its influence on the development of intestinal polyps in Min mice. Female Min mice at 4 weeks old were given 400 ppm nimesulide in their diet for 11 weeks. This treatment resulted in a significant reduction of the numbers of both small and large intestinal polyps, the total being 52% of that in untreated control Min mice. The size of the polyps in the nimesulide-treated group was also significantly decreased. The results suggest that nimesulide is a good candidate as a chemopreventive agent for human colon cancer with low toxicity. | ||||
Links |
J:45606 – MGI References 9473726 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine adenoma | Intestine - Large Intestine |
observed |
||
C57BL/6J-ApcMin/+ | Intestine - Large Intestine adenoma |
|
Intestine - Large Intestine |
observed |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Distal adenoma | Intestine - Small Intestine - Distal |
observed |
||
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Distal adenoma |
|
Intestine - Small Intestine - Distal |
observed |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Medial adenoma | Intestine - Small Intestine - Medial |
observed |
||
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Medial adenoma |
|
Intestine - Small Intestine - Medial |
observed |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Proximal adenoma | Intestine - Small Intestine - Proximal |
observed |
||
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Proximal adenoma |
|
Intestine - Small Intestine - Proximal |
observed |
|
C57BL/6J-ApcMin/+ | Intestine adenoma | Intestine |
observed |
||
C57BL/6J-ApcMin/+ | Intestine adenoma |
|
Intestine |
observed |