Reference SummaryPino MV, Toxicol Pathol 2004 Jan-Feb;32(1):58-63
Title |
Promotion of Colon Tumors in C57BL/6J-APC(min)/+ Mice by Thiazolidinedione PPARgamma Agonists and a Structurally Unrelated PPARgamma Agonist. | ||||
Authors |
Pino MV; Kelley MF; Jayyosi Z | ||||
Journal |
Toxicol Pathol | ||||
Volume |
32 | ||||
Issue |
1 | ||||
Year |
2004 | ||||
Pages |
58-63 | ||||
Abstract |
Thiazolidinedione PPARgamma agonists (troglitazone and rosiglitazone) were previously shown to promote colon tumor formation in C57BL/6J-APC(min)/+ mice, a model for human familial adenomatous polyposis. This study was conducted to determine if another thiazolidinedione PPARgamma agonist, pioglitazone, and a PPARgamma agonist structurally unrelated to the thiazolidinedione family, NID525, (a tetrazole-substituted phenoxymethylquinolone), would also promote colon tumors in this mouse model. Mice were treated in-feed with the thiazolidinediones troglitazone (150 mg/kg/day), rosiglitazone (20 mg/kg/day), or pioglitazone (150 mg/kg/day), or with NID525 (150 mg/kg/day) for 8 weeks. An increased incidence in colon tumors compared to controls was observed for all of the thiazolidinedione-treated groups as well as the NID525-treated group. These results indicate that the tumor-promoting effect of PPARgamma agonists in the colon of C57BL/6J-APC(min)/+ mice is likely related to the pharmacological activity of this group of drugs and not the thiazolidinedione structure. | ||||
Links |
J:88111 – MGI References 14713549 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine adenocarcinoma | Intestine - Large Intestine |
0 |
||
C57BL/6J-ApcMin/+ | Intestine - Large Intestine adenocarcinoma |
|
Intestine - Large Intestine |
0 |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine adenocarcinoma |
|
Intestine - Large Intestine |
6.7 |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine adenocarcinoma |
|
Intestine - Large Intestine |
0 |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine adenocarcinoma |
|
Intestine - Large Intestine |
0 |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine adenoma | Intestine - Large Intestine |
60 |
||
C57BL/6J-ApcMin/+ | Intestine - Large Intestine adenoma |
|
Intestine - Large Intestine |
100 |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine adenoma |
|
Intestine - Large Intestine |
observed |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine adenoma |
|
Intestine - Large Intestine |
100 |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine adenoma |
|
Intestine - Large Intestine |
100 |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine hyperplasia | Intestine - Large Intestine |
observed |
||
C57BL/6J-ApcMin/+ | Intestine - Large Intestine hyperplasia |
|
Intestine - Large Intestine |
observed |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine hyperplasia |
|
Intestine - Large Intestine |
observed |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine hyperplasia |
|
Intestine - Large Intestine |
observed |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine hyperplasia |
|
Intestine - Large Intestine |
observed |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine tumor |
|
Intestine - Large Intestine |
93 |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Distal adenoma | Intestine - Small Intestine - Distal |
100 |
||
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Distal adenoma |
|
Intestine - Small Intestine - Distal |
100 |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Distal tumor |
|
Intestine - Small Intestine - Distal |
100 |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Distal tumor |
|
Intestine - Small Intestine - Distal |
100 |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Distal tumor |
|
Intestine - Small Intestine - Distal |
100 |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Proximal adenoma | Intestine - Small Intestine - Proximal |
100 |
||
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Proximal adenoma |
|
Intestine - Small Intestine - Proximal |
100 |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Proximal tumor |
|
Intestine - Small Intestine - Proximal |
100 |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Proximal tumor |
|
Intestine - Small Intestine - Proximal |
100 |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Proximal tumor |
|
Intestine - Small Intestine - Proximal |
100 |