Reference SummaryZiegler CC, J Nutr 2004 Jan;134(1):5-10
Title |
Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice. | ||||
Authors |
Ziegler CC; Rainwater L; Whelan J; McEntee MF | ||||
Journal |
J Nutr | ||||
Volume |
134 | ||||
Issue |
1 | ||||
Year |
2004 | ||||
Pages |
5-10 | ||||
Abstract |
To determine its effect on intestinal tumorigenesis and the protumorigenic COX pathway in Apc(Min/+) mice, resveratrol was administered as a powdered admixture in the diet at 0, 4, 20, or 90 mg/kg body weight for 7 wk. In two separate experiments, resveratrol did not affect intestinal tumor load. It was stable in the diet under experimental conditions, circulated in the plasma as the glucuronide-conjugated form and reached the tumors as evidenced by significant decreases in PGE2 levels. However, immunohistochemical staining of intestinal tumors revealed no changes in COX-2 expression. This study demonstrates that resveratrol consumed ad libitum in the diet, does not modify tumorigenesis in Apc(Min/+) mice. | ||||
Links |
J:88124 – MGI References 14704285 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine tumor | Intestine - Large Intestine |
observed |
||
C57BL/6J-ApcMin/+ | Intestine - Large Intestine tumor |
|
Intestine - Large Intestine |
observed |
|
C57BL/6J-ApcMin/+ | Intestine - Small Intestine tumor | Intestine - Small Intestine |
observed |
||
C57BL/6J-ApcMin/+ | Intestine - Small Intestine tumor |
|
Intestine - Small Intestine |
observed |