Reference SummaryGupta RA, Nat Med 2004 Mar;10(3):245-7
Title |
Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. | ||||
Authors |
Gupta RA; Wang D; Katkuri S; Wang H; Dey SK; DuBois RN | ||||
Journal |
Nat Med | ||||
Volume |
10 | ||||
Issue |
3 | ||||
Year |
2004 | ||||
Pages |
245-7 | ||||
Abstract |
We treated Apc(min) mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-delta (PPAR-delta). Exposure of Apc(min) mice to the PPAR-delta ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-delta in the regulation of intestinal adenoma growth. | ||||
Links |
J:88127 – MGI References 14758356 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine - Colon polyp |
|
Intestine - Large Intestine - Colon |
observed |
|
C57BL/6J-ApcMin/+ | Intestine - Large Intestine - Colon polyp | Intestine - Large Intestine - Colon |
observed |
||
C57BL/6J-ApcMin/+ | Intestine - Large Intestine polyp | Intestine - Large Intestine |
observed |
||
C57BL/6J-ApcMin/+ | Intestine - Small Intestine polyp | Intestine - Small Intestine |
observed |
||
C57BL/6J-ApcMin/+ | Intestine - Small Intestine polyp |
|
Intestine - Small Intestine |
observed |