Reference SummaryLiu S, Cancer Cell 2009 Jun 2;15(6):539-50
Title |
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. |
Authors |
Liu S; Umezu-Goto M; Murph M; Lu Y; Liu W; Zhang F; Yu S; Stephens LC; Cui X; Murrow G; Coombes K; Muller W; Hung MC; Perou CM; Lee AV; Fang X; Mills GB |
Journal |
Cancer Cell |
Volume |
15 |
Issue |
6 |
Year |
2009 |
Pages |
539-50 |
Abstract |
Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer. |
Links |
J:149661 – MGI References 19477432 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| FVB/N-Tg(MMTV-ENPP2)20Gbm | Mammary gland adenocarcinoma | Mammary gland |
observed |
||
| FVB/N-Tg(MMTV-LPAR1)2Gbm | Mammary gland adenocarcinoma | Mammary gland |
observed |
||
| FVB/N-Tg(MMTV-ENPP2)21Gbm | Mammary gland adenocarcinoma | Mammary gland |
observed |
||
| FVB/N-Tg(MMTV-LPAR3)3Gbm | Mammary gland adenocarcinoma | Mammary gland |
observed |
||
| FVB/N-Tg(MMTV-LPAR1)#Gbm | Mammary gland carcinoma | Mammary gland |
32 |
||
| FVB/N-Tg(MMTV-LPAR2)#Gbm | Mammary gland carcinoma | Mammary gland |
52.83 |
||
| FVB/N-Tg(MMTV-LPAR3)#Gbm | Mammary gland carcinoma | Mammary gland |
42.3 |
||
| FVB/N-Tg(MMTV-ENPP2)#Gbm | Mammary gland carcinoma | Mammary gland |
50 |
||
| FVB/N-Tg(MMTV-LPAR1)2Gbm | Mammary gland carcinoma | Mammary gland |
21 |
||
| FVB/N-Tg(MMTV-LPAR1)7Gbm | Mammary gland carcinoma | Mammary gland |
30 |
||
| FVB/N-Tg(MMTV-LPAR1)27Gbm | Mammary gland carcinoma | Mammary gland |
42.86 |
||
| FVB/N-Tg(MMTV-LPAR2)3Gbm | Mammary gland carcinoma | Mammary gland |
52 |
||
| FVB/N-Tg(MMTV-LPAR2)6Gbm | Mammary gland carcinoma | Mammary gland |
54 |
||
| FVB/N-Tg(MMTV-LPAR3)3Gbm | Mammary gland carcinoma | Mammary gland |
43 |
||
| FVB/N-Tg(MMTV-LPAR3)22Gbm | Mammary gland carcinoma | Mammary gland |
33 |
||
| FVB/N-Tg(MMTV-ENPP2)20Gbm | Mammary gland carcinoma | Mammary gland |
62 |
||
| FVB/N-Tg(MMTV-ENPP2)21Gbm | Mammary gland carcinoma | Mammary gland |
37 |
||
| FVB/N-Tg(MMTV-LPAR1)#Gbm | Mammary gland carcinoma - invasive | Mammary gland |
22 |
||
| FVB/N-Tg(MMTV-LPAR2)#Gbm | Mammary gland carcinoma - invasive | Mammary gland |
43.4 |
||
| FVB/N-Tg(MMTV-LPAR3)#Gbm | Mammary gland carcinoma - invasive | Mammary gland |
23.08 |
||
| FVB/N-Tg(MMTV-ENPP2)#Gbm | Mammary gland carcinoma - invasive | Mammary gland |
37.5 |
||
| FVB/N-Tg(MMTV-LPAR1)2Gbm | Mammary gland carcinoma - invasive | Mammary gland |
15.79 |
||
| FVB/N-Tg(MMTV-LPAR1)7Gbm | Mammary gland carcinoma - invasive | Mammary gland |
20 |
||
| FVB/N-Tg(MMTV-LPAR1)27Gbm | Mammary gland carcinoma - invasive | Mammary gland |
28.57 |
||
| FVB/N-Tg(MMTV-LPAR2)3Gbm | Mammary gland carcinoma - invasive | Mammary gland |
40 |
||
| FVB/N-Tg(MMTV-LPAR2)6Gbm | Mammary gland carcinoma - invasive | Mammary gland |
46.43 |
||
| FVB/N-Tg(MMTV-LPAR3)3Gbm | Mammary gland carcinoma - invasive | Mammary gland |
26.09 |
||
| FVB/N-Tg(MMTV-LPAR3)22Gbm | Mammary gland carcinoma - invasive | Mammary gland |
0 |
||
| FVB/N-Tg(MMTV-ENPP2)20Gbm | Mammary gland carcinoma - invasive | Mammary gland |
52.38 |
||
| FVB/N-Tg(MMTV-ENPP2)21Gbm | Mammary gland carcinoma - invasive | Mammary gland |
21.05 |
||
| FVB/N | Mammary gland hyperplasia | Mammary gland |
4.55 |
||
| FVB/N-Tg(MMTV-LPAR1)#Gbm | Mammary gland hyperplasia | Mammary gland |
16 |
||
| FVB/N-Tg(MMTV-LPAR2)#Gbm | Mammary gland hyperplasia | Mammary gland |
7.55 |
||
| FVB/N-Tg(MMTV-LPAR3)#Gbm | Mammary gland hyperplasia | Mammary gland |
23.08 |
||
| FVB/N-Tg(MMTV-ENPP2)#Gbm | Mammary gland hyperplasia | Mammary gland |
27.5 |
||
| FVB/N-Tg(MMTV-LPAR1)2Gbm | Mammary gland hyperplasia | Mammary gland |
15.79 |
||
| FVB/N-Tg(MMTV-LPAR1)7Gbm | Mammary gland hyperplasia | Mammary gland |
30 |
||
| FVB/N-Tg(MMTV-LPAR1)27Gbm | Mammary gland hyperplasia | Mammary gland |
9.52 |
||
| FVB/N-Tg(MMTV-LPAR2)3Gbm | Mammary gland hyperplasia | Mammary gland |
12 |
||
| FVB/N-Tg(MMTV-LPAR2)6Gbm | Mammary gland hyperplasia | Mammary gland |
3.57 |
||
| FVB/N-Tg(MMTV-LPAR3)3Gbm | Mammary gland hyperplasia | Mammary gland |
21.74 |
||
| FVB/N-Tg(MMTV-LPAR3)22Gbm | Mammary gland hyperplasia | Mammary gland |
33.33 |
||
| FVB/N-Tg(MMTV-ENPP2)20Gbm | Mammary gland hyperplasia | Mammary gland |
4.76 |
||
| FVB/N-Tg(MMTV-ENPP2)21Gbm | Mammary gland hyperplasia | Mammary gland |
52.63 |
||
| FVB/N-Tg(MMTV-LPAR1)27Gbm | Mammary gland hyperplasia - ductal | Mammary gland |
observed |
||
| FVB/N-Tg(MMTV-LPAR2)6Gbm | Mammary gland hyperplasia - ductal | Mammary gland |
observed |
||
| FVB/N-Tg(MMTV-LPAR3)3Gbm | Mammary gland hyperplasia - ductal | Mammary gland |
observed |
||
| FVB/N | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
0 |
||
| FVB/N-Tg(MMTV-LPAR1)#Gbm | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
6 |
||
| FVB/N-Tg(MMTV-LPAR2)#Gbm | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
5.66 |
||
| FVB/N-Tg(MMTV-LPAR3)#Gbm | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
0 |
||
| FVB/N-Tg(MMTV-ENPP2)#Gbm | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
10 |
||
| FVB/N-Tg(MMTV-LPAR1)2Gbm | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
0 |
||
| FVB/N-Tg(MMTV-LPAR1)7Gbm | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
0 |
||
| FVB/N-Tg(MMTV-LPAR1)27Gbm | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
14.29 |
||
| FVB/N-Tg(MMTV-LPAR2)3Gbm | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
8 |
||
| FVB/N-Tg(MMTV-LPAR2)6Gbm | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
3.57 |
||
| FVB/N-Tg(MMTV-LPAR3)3Gbm | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
0 |
||
| FVB/N-Tg(MMTV-LPAR3)22Gbm | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
0 |
||
| FVB/N-Tg(MMTV-ENPP2)20Gbm | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
4.76 |
||
| FVB/N-Tg(MMTV-ENPP2)21Gbm | Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
15.79 |
||
| FVB/N | Mammary gland metaplasia - squamous | Mammary gland |
2.27 |
||
| FVB/N-Tg(MMTV-LPAR1)#Gbm | Mammary gland metaplasia - squamous | Mammary gland |
10 |
||
| FVB/N-Tg(MMTV-LPAR2)#Gbm | Mammary gland metaplasia - squamous | Mammary gland |
9.43 |
||
| FVB/N-Tg(MMTV-LPAR3)#Gbm | Mammary gland metaplasia - squamous | Mammary gland |
3.85 |
||
| FVB/N-Tg(MMTV-ENPP2)#Gbm | Mammary gland metaplasia - squamous | Mammary gland |
0 |
||
| FVB/N-Tg(MMTV-LPAR1)2Gbm | Mammary gland metaplasia - squamous | Mammary gland |
10.53 |
||
| FVB/N-Tg(MMTV-LPAR1)7Gbm | Mammary gland metaplasia - squamous | Mammary gland |
30 |
||
| FVB/N-Tg(MMTV-LPAR1)27Gbm | Mammary gland metaplasia - squamous | Mammary gland |
0 |
||
| FVB/N-Tg(MMTV-LPAR2)3Gbm | Mammary gland metaplasia - squamous | Mammary gland |
4 |
||
| FVB/N-Tg(MMTV-LPAR2)6Gbm | Mammary gland metaplasia - squamous | Mammary gland |
14.29 |
||
| FVB/N-Tg(MMTV-LPAR3)3Gbm | Mammary gland metaplasia - squamous | Mammary gland |
4.35 |
||
| FVB/N-Tg(MMTV-LPAR3)22Gbm | Mammary gland metaplasia - squamous | Mammary gland |
0 |
||
| FVB/N-Tg(MMTV-ENPP2)20Gbm | Mammary gland metaplasia - squamous | Mammary gland |
0 |
||
| FVB/N-Tg(MMTV-ENPP2)21Gbm | Mammary gland metaplasia - squamous | Mammary gland |
0 |
||
| FVB/N | Mammary gland tumor | Mammary gland |
0 |
||
| FVB/N | Mammary gland tumor | Mammary gland |
0 |