Strain SummaryFVB/N
Strain Name |
FVB/N |
Strain Type(s) |
inbred |
Strain Synonym(s) |
albino FVB/N • control • control FVB • FVB • FVB/n • FVB nontransgenic • N/E2 • non-transgenic • nontransgenic FVB • nontransgenic FVB/N • wild type • wild-type • wild-type FVB • wild-type FVB/N |
Strain Links |
• Festing's List of Inbred Strains |
Frequency | ||||||||
---|---|---|---|---|---|---|---|---|
Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
Adrenal gland - Cortex tumor | Adrenal gland - Cortex | ovariectomy |
0 |
References: Bielinska M, Endocrinology 2003 Sep;144(9):4123-33 |
||||
Connective tissue - Fibroblast fibrosarcoma | Connective tissue - Fibroblast | Ad5-CMV-Cre (AdCre) (AdCMVCre) |
0 |
References: Choi J, Am J Pathol 2010 Nov;177(5):2645-58 |
||||
Esophagus dysplasia | Esophagus |
0 |
References: Mueller A, Cancer Res 1997 Dec 15;57(24):5542-9 ⋅ Nakagawa H, Oncogene 1997 Mar 13;14(10):1185-90 |
|||||
Forestomach dysplasia | Forestomach |
0 |
References: Nakagawa H, Oncogene 1997 Mar 13;14(10):1185-90 |
|||||
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte | Ad5-CMV-Cre (AdCre) (AdCMVCre) |
0 |
References: Choi J, Am J Pathol 2010 Nov;177(5):2645-58 |
||||
Liver normal tissue (control) | Liver |
not applicable |
References: Shachaf CM, Nature 2004 Oct 28;431(7012):1112-7 |
|||||
Liver tumor | Liver | diethylnitrosamine (DEN) |
observed |
References: Kuklin AI, Mol Cancer 2004 Jun 2;3(1):17 |
||||
Lung - Alveolus hyperplasia | Lung - Alveolus | doxycycline |
0 |
References: Floyd HS, Carcinogenesis 2005 Dec;26(12):2196-206 |
||||
Lung - Alveolus hyperplasia - focal | Lung - Alveolus |
0 |
References: Floyd HS, Carcinogenesis 2005 Dec;26(12):2196-206 |
|||||
Lung adenocarcinoma | Lung |
0 - 6.45 |
References: Duan W, Oncogene 2002 Nov 7;21(51):7831-8 |
|||||
Lung carcinoma | Lung |
29 |
References: Shafarenko M, Carcinogenesis 1997 Jul;18(7):1423-6 |
|||||
Lung hyperplasia - focal | Lung | doxycycline |
0 |
References: Floyd HS, Carcinogenesis 2005 Dec;26(12):2196-206 |
||||
Lung hyperplasia - focal | Lung |
0 |
References: Floyd HS, Carcinogenesis 2005 Dec;26(12):2196-206 |
|||||
Lung tumor | Lung | Adenovirus - recombinant, expressing Cre recombinase |
0 |
References: Meuwissen R, Oncogene 2001 Oct 4;20(45):6551-8 |
||||
Lung tumor | Lung | doxycycline |
0 |
References: Floyd HS, Carcinogenesis 2005 Dec;26(12):2196-206 |
||||
Lung tumor | Lung |
0 |
References: Floyd HS, Carcinogenesis 2005 Dec;26(12):2196-206 |
|||||
Mammary gland adenoacanthoma | Mammary gland | pituitary isograft ⋅ 7,12-dimethylbenz[a]anthracene (DMBA) |
observed |
References: Li B, Oncogene 1998 Feb 26;16(8):997-1007 |
||||
Mammary gland adenocarcinoma | Mammary gland | pituitary isograft ⋅ 7,12-dimethylbenz[a]anthracene (DMBA) |
observed |
References: Li B, Oncogene 1998 Feb 26;16(8):997-1007 Sites of Metastasis: Lung |
||||
Mammary gland foci | Mammary gland |
0 |
References: Pravtcheva DD, J Exp Zool 1998 May 1;281(1):43-57 |
|||||
Mammary gland hyperplasia | Mammary gland |
0 - observed |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 ⋅ Gallego MI, Oncogene 2003 Nov 20;22(52):8498-508 ⋅ Rudolph-Owen LA, Cancer Res 1998 Dec 1;58(23):5500-6 |
|||||
Mammary gland hyperplasia - alveolar | Mammary gland |
0 |
References: Pravtcheva DD, J Exp Zool 1998 May 1;281(1):43-57 |
|||||
Mammary gland metaplasia - squamous | Mammary gland | pituitary isograft ⋅ 7,12-dimethylbenz[a]anthracene (DMBA) |
observed |
References: Li B, Oncogene 1998 Feb 26;16(8):997-1007 |
||||
Mammary gland tumor | Mammary gland |
0 |
0 |
0 |
References: Gallahan D, Cancer Res 1996 Apr 15;56(8):1775-85 ⋅ Liu S, Cancer Cell 2009 Jun 2;15(6):539-50 ⋅ Maroulakou IG, Proc Natl Acad Sci U S A 1994 Nov 8;91(23):11236-40 ⋅ Pravtcheva DD, J Exp Zool 1998 May 1;281(1):43-57 ⋅ Smith GH, Am J Pathol 1995 Oct;147(4):1081-96 ⋅ Takayama H, Proc Natl Acad Sci U S A 1997 Jan 21;94(2):701-6 |
|||
Mammary gland tumor | Mammary gland | pituitary isograft ⋅ 7,12-dimethylbenz[a]anthracene (DMBA) |
77.0 - 85.0 |
References: Li B, Oncogene 1998 Feb 26;16(8):997-1007 |
||||
Mesodermal cell/mesoblast sarcoma - pleomorphic - undifferentiated | Mesodermal cell/mesoblast | Ad5-CMV-Cre (AdCre) (AdCMVCre) |
0 |
References: Choi J, Am J Pathol 2010 Nov;177(5):2645-58 |
||||
Mesodermal cell/mesoblast sarcoma - spindle cell | Skin |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
|||||
Mesodermal cell/mesoblast sarcoma - spindle cell | Skin | phorbol 12-myristate 13-acetate (phorbol ester) (PMA) |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
||||
Mesodermal cell/mesoblast sarcoma - spindle cell | Skin | retinoic acid (RA) |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
||||
Mesodermal cell/mesoblast sarcoma - spindle cell | Skin | phorbol 12-myristate 13-acetate (phorbol ester) (PMA) ⋅ retinoic acid (RA) |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
||||
Mesodermal cell/mesoblast sarcoma - spindle cell | Skin | wounding |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
||||
Muscle - Smooth leiomyosarcoma | Muscle - Smooth | Ad5-CMV-Cre (AdCre) (AdCMVCre) |
0 |
References: Choi J, Am J Pathol 2010 Nov;177(5):2645-58 |
||||
Muscle - Striated - Skeletal rhabdomyosarcoma | Muscle - Striated - Skeletal |
0 |
0 |
References: Takayama H, Proc Natl Acad Sci U S A 1997 Jan 21;94(2):701-6 |
||||
Muscle - Striated - Skeletal rhabdomyosarcoma | Muscle - Striated - Skeletal | Ad5-CMV-Cre (AdCre) (AdCMVCre) |
0 |
References: Choi J, Am J Pathol 2010 Nov;177(5):2645-58 |
||||
Nose - Nasal cavity - Nasal gland hyperplasia | Nose - Nasal cavity - Nasal gland |
0 |
References: Jhappan C, Genes Dev 1992 Mar;6(3):345-55 |
|||||
Prostate gland tumor | Prostate gland |
0 |
References: Maroulakou IG, Proc Natl Acad Sci U S A 1994 Nov 8;91(23):11236-40 |
|||||
Skin - Dorsal region papilloma | Skin - Dorsal region | 12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ dimethylbenzanthracene (DMBA) |
100 |
References: Ridd K, Carcinogenesis 2006 Aug;27(8):1556-66 |
||||
Skin - Dorsal region papilloma | Skin - Dorsal region | 12-O-tetradecanoylphorbol-13-acetate (TPA) |
0 |
References: Ridd K, Carcinogenesis 2006 Aug;27(8):1556-66 |
||||
Skin - Ear squamous cell carcinoma | Skin - Ear | ear tag |
observed |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
||||
Skin - Melanocyte melanoma | Skin - Melanocyte |
0 |
References: Otsuka T, Cancer Res 1998 Nov 15;58(22):5157-67 |
|||||
Skin - Melanocyte melanoma - amelanotic | Skin - Melanocyte |
0 |
0 |
References: Takayama H, Proc Natl Acad Sci U S A 1997 Jan 21;94(2):701-6 |
||||
Skin carcinoma | Skin | 12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA) |
observed |
References: Woodworth CD, Carcinogenesis 2004 Sep;25(9):1771-8 |
||||
Skin dermatofibroma | Skin | Ad5-CMV-Cre (AdCre) (AdCMVCre) |
0 |
References: Choi J, Am J Pathol 2010 Nov;177(5):2645-58 |
||||
Skin hyperplasia | Skin | phorbol 12-myristate 13-acetate (phorbol ester) (PMA) |
observed |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
||||
Skin papilloma | Skin |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
|||||
Skin papilloma | Skin | phorbol 12-myristate 13-acetate (phorbol ester) (PMA) |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
||||
Skin papilloma | Skin | retinoic acid (RA) |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
||||
Skin papilloma | Skin | phorbol 12-myristate 13-acetate (phorbol ester) (PMA) ⋅ retinoic acid (RA) |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
||||
Skin papilloma | Skin | wounding |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
||||
Skin papilloma | Skin | 12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA) |
observed |
References: Woodworth CD, Carcinogenesis 2004 Sep;25(9):1771-8 |
||||
Skin squamous cell carcinoma | Skin |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
|||||
Skin squamous cell carcinoma | Skin | phorbol 12-myristate 13-acetate (phorbol ester) (PMA) |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
||||
Skin squamous cell carcinoma | Skin | retinoic acid (RA) |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
||||
Skin squamous cell carcinoma | Skin | phorbol 12-myristate 13-acetate (phorbol ester) (PMA) ⋅ retinoic acid (RA) |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
||||
Skin squamous cell carcinoma | Skin | wounding |
0 |
References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82 |
||||
Stomach lesion | Stomach |
0 |
References: Syder AJ, Proc Natl Acad Sci U S A 2004 Mar 30;101(13):4471-6 |
|||||
Subcutis tumor | Subcutis | Ad5-CMV-Cre (AdCre) (AdCMVCre) |
0 |
References: Choi J, Am J Pathol 2010 Nov;177(5):2645-58 |
||||
Subcutis tumor | Subcutis | Ad5-CMV-LacZ (AdCMVLacZ) |
0 |
References: Choi J, Am J Pathol 2010 Nov;177(5):2645-58 |
||||
Thymus hyperplasia | Thymus |
100 |
References: Scheijen B, J Biol Chem 2004 Mar 12;279(11):10476-83 |
|||||
Tongue dysplasia | Tongue |
0 |
References: Mueller A, Cancer Res 1997 Dec 15;57(24):5542-9 ⋅ Nakagawa H, Oncogene 1997 Mar 13;14(10):1185-90 |
|||||
Urinary bladder tumor | Urinary bladder |
0 |
References: Zhang ZT, Cancer Res 1999 Jul 15;59(14):3512-7 |
|||||
Uterus - Cervix cervical intraepithelial neoplasia (CIN) | Uterus - Cervix | 17beta-estradiol (E2) |
0 |
References: Giraudo E, J Clin Invest 2004 Sep;114(5):623-33 |
||||
Uterus - Cervix squamous cell carcinoma | Uterus - Cervix | 17beta-estradiol (E2) |
0 |
References: Giraudo E, J Clin Invest 2004 Sep;114(5):623-33 |
||||
(Unspecified organ) angiosarcoma | (Unspecified organ) | Ad5-CMV-Cre (AdCre) (AdCMVCre) |
0 |
References: Choi J, Am J Pathol 2010 Nov;177(5):2645-58 |
||||
(Unspecified organ) tumor | (Unspecified organ) |
0 |
References: Jimenez M, Cancer Res 2004 Sep 1;64(17):6041-9 |