Reference SummaryAdkins B Jr, J Toxicol Environ Health 1986;17(2-3):311-22
Title |
Oncogenic response of strain A/J mice to inhaled chemicals. |
Authors |
Adkins B Jr; Van Stee EW; Simmons JE; Eustis SL |
Journal |
J Toxicol Environ Health |
Volume |
17 |
Issue |
2-3 |
Year |
1986 |
Pages |
311-22 |
Abstract |
Strain A/J mice were exposed by inhalation for 6 h/d, 5 d/wk, for 6 mo to carbon disulfide, 1,2-dibromoethane, ethylene oxide, naphthalene, nitrogen dioxide, or vinyl chloride. Significant increases in pulmonary adenoma formation were observed following exposure to 300 ppm carbon disulfide; 20 and 50 ppm 1,2-dibromoethane; 70 and 200 ppm ethylene oxide; 10 ppm nitrogen dioxide; and 50, 200, and 500 ppm vinyl chloride compared to control animals. Repeated studies with 1,2-dibromoethane, ethylene oxide, and vinyl chloride gave similarly significant results. Exposure of mice to 30 ppm naphthalene did not elicit a significant adenoma response. Histopathological examination of lungs from animals in these studies revealed multiple alveolar adenomas. Results from earlier studies with these chemicals, using strain A mice and Swiss mice, and bioassay information with rats and mice were compared with these data. These results provide further information for the validation of this in vivo model as a tool for predicting oncogenic potential following chemical exposure. |
Links |
J:22707 – MGI References 3083111 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| A/J | Lung - Alveolus adenoma | Lung - Alveolus |
21 - 51 |
||
| A/J | Lung - Alveolus adenoma |
|
Lung - Alveolus |
74 - 100 |
|
| A/J | Lung - Alveolus adenoma |
|
Lung - Alveolus |
39 |
|
| A/J | Lung - Alveolus adenoma |
|
Lung - Alveolus |
68 - 100 |
|
| A/J | Lung - Alveolus adenoma |
|
Lung - Alveolus |
42 - 87 |
|
| A/J | Lung - Alveolus adenoma |
|
Lung - Alveolus |
29 - 30 |
|
| A/J | Lung - Alveolus adenoma |
|
Lung - Alveolus |
observed - 12 |
|
| A/J | Lung - Alveolus adenoma |
|
Lung - Alveolus |
100 |
|
| A/J | Lung - Alveolus hyperplasia |
|
Lung - Alveolus |
observed |
|
| A/J | Lung - Bronchiole adenoma |
|
Lung - Bronchiole |
observed |
|
| A/J | Lung - Bronchiole hyperplasia |
|
Lung - Bronchiole |
observed |
|
| A/J | Lung carcinoma | Lung |
0 |
||
| A/J | Lung carcinoma |
|
Lung |
0 |
|
| A/J | Lung carcinoma |
|
Lung |
0 |
|
| A/J | Lung carcinoma |
|
Lung |
0 |
|
| A/J | Lung carcinoma |
|
Lung |
0 |
|
| A/J | Lung carcinoma |
|
Lung |
0 |
|
| A/J | Lung carcinoma |
|
Lung |
0 |
|
| A/J | Lung carcinoma |
|
Lung |
0 |