Reference SummaryVan Der Kraak L, Mamm Genome 2016 Jun;27(5-6):213-24
Title |
Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice. |
Authors |
Van Der Kraak L; Langlais D; Jothy S; Beauchemin N; Gros P |
Journal |
Mamm Genome |
Volume |
27 |
Issue |
5-6 |
Year |
2016 |
Pages |
213-24 |
Abstract |
Inbred strains of mice differ in susceptibility to colitis-associated colorectal cancer (CA-CRC). We tested 10 inbred strains of mice for their response to azoxymethane/dextran sulfate sodium-induced CA-CRC and identified a bimodal inter-strain distribution pattern when tumor multiplicity was used as a phenotypic marker of susceptibility. The FVB/NJ strain was particularly susceptible showing a higher tumor burden than any other susceptible strains (12.5-week post-treatment initiation). FVB/NJ hyper-susceptibility was detected as early as 8-week post-treatment initiation with FVB/NJ mice developing 5.5-fold more tumors than susceptible A/J or resistant B6 control mice. Linkage analysis by whole genome scan in informative (FVB/NJxC3H/HeJ)F2 mice identified a novel susceptibility locus designated as C olon c ancer s usceptibility 6 (Ccs6) on proximal mouse chromosome 6. When gender was used as a covariate, a LOD score of 5.4 was computed with the peak marker being positioned at rs13478727, 43.8 Mbp. Mice homozygous for FVB/NJ alleles at this locus had increased tumor multiplicity compared to homozygous C3H/HeJ mice. Positional candidates in this region of chromosome 6 were analyzed with respect to a possible role in carcinogenesis and a role in inflammatory response using a new epigenetic gene scoring tool (Myeloid Inflammation Score). |
Links |
J:242437 – MGI References 26979842 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| FVB/NJ | Intestine - Large Intestine - Colon adenocarcinoma |
|
Intestine - Large Intestine - Colon |
0 |
|
| C3H/HeJ | Intestine - Large Intestine - Colon adenocarcinoma |
|
Intestine - Large Intestine - Colon |
0 |
|
| FVB/NJ | Intestine - Large Intestine - Colon adenoma |
|
Intestine - Large Intestine - Colon |
observed |
|
| C3H/HeJ | Intestine - Large Intestine - Colon adenoma |
|
Intestine - Large Intestine - Colon |
observed |
|
| FVB/NJ | Intestine - Large Intestine - Colon carcinoma - adenosquamous |
|
Intestine - Large Intestine - Colon |
observed |
|
| FVB/NJ | Intestine - Large Intestine - Colon dysplasia - high grade |
|
Intestine - Large Intestine - Colon |
observed |
|
| C3H/HeJ | Intestine - Large Intestine - Colon dysplasia - high grade |
|
Intestine - Large Intestine - Colon |
0 |
|
| FVB/NJ | Intestine - Large Intestine - Colon dysplasia - low grade |
|
Intestine - Large Intestine - Colon |
observed |
|
| C3H/HeJ | Intestine - Large Intestine - Colon dysplasia - low grade |
|
Intestine - Large Intestine - Colon |
observed |
|
| FVB/NJ | Intestine - Large Intestine - Colon lesion |
|
Intestine - Large Intestine - Colon |
observed |
|
| C3H/HeJ | Intestine - Large Intestine - Colon lesion |
|
Intestine - Large Intestine - Colon |
observed |
|
| (FVB/NJ x C3H/HeJ)F1 | Intestine - Large Intestine - Colon lesion |
|
Intestine - Large Intestine - Colon |
observed |
|
| (FVB/NJ x C3H/HeJ)F2 | Intestine - Large Intestine - Colon lesion |
|
Intestine - Large Intestine - Colon |
observed |
|
| NOD/ShiLtJ | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
0 - 100 |
|
| FVB/NJ | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
observed - 100 |
|
| AKR/J | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
100 |
|
| C3H/HeJ | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
observed - 100 |
|
| 129S1/SvImJ | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
100 |
|
| C57BL/6J | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
100 |
|
| DBA/2J | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
100 |
|
| CBA/J | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
100 |
|
| A/J | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
100 |
|
| BALB/cByJ | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
100 |
|
| FVB/NJ | Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon |
0 |
||
| (FVB/NJ x C3H/HeJ)F1 | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
observed |
|
| (FVB/NJ x C3H/HeJ)F2 | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
observed |
|
| AKR/J | Intestine - Large Intestine tumor |
|
Intestine - Large Intestine |
100 |
|
| C3H/HeJ | Intestine - Large Intestine tumor |
|
Intestine - Large Intestine |
100 |
|
| 129S1/SvImJ | Intestine - Large Intestine tumor |
|
Intestine - Large Intestine |
100 |
|
| C57BL/6J | Intestine - Large Intestine tumor |
|
Intestine - Large Intestine |
100 |
|
| DBA/2J | Intestine - Large Intestine tumor |
|
Intestine - Large Intestine |
100 |
|
| CBA/J | Intestine - Large Intestine tumor |
|
Intestine - Large Intestine |
100 |
|
| A/J | Intestine - Large Intestine tumor |
|
Intestine - Large Intestine |
100 |
|
| BALB/cByJ | Intestine - Large Intestine tumor |
|
Intestine - Large Intestine |
100 |
|
| FVB/NJ | Intestine - Large Intestine tumor |
|
Intestine - Large Intestine |
observed - 100 |
|
| NOD/ShiLtJ | Intestine - Large Intestine tumor |
|
Intestine - Large Intestine |
100 |
|
| FVB/NJ | Intestine - Large Intestine tumor | Intestine - Large Intestine |
0 |