Reference SummaryCosgrove GE, J Gerontol 1978 Mar;33(2):178-83
Title |
Diseases of aging untreated virgin female RFM and BALB/c mice. | ||||||||
Authors |
Cosgrove GE; Satterfield LC; Bowles ND; Klima WC | ||||||||
Journal |
J Gerontol | ||||||||
Volume |
33 | ||||||||
Issue |
2 | ||||||||
Year |
1978 | ||||||||
Pages |
178-83 | ||||||||
Abstract |
Diseases of untreated, virgin female barrier-maintained RFM and BALB/c mice used as controls in a large radiation aging experiment were necropsied after natural death. The spectrum and incidence of neoplastic and nonneoplastic diseases were somewhat different in the two strains. Both strains show a high incidence of neoplasma (largely reticulum cell sarcomas and lung tumors) and of glomerulosclerosis. A wide variety of other diseases was noted in much lower incidence. The findings in the RF were briefly compared with those in earlier experiments with that strain in this laboratory. | ||||||||
Links |
J:27633 – MGI References 342593 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
RFM/Un | Adrenal gland - Cortex hyperplasia | Adrenal gland - Cortex |
2 |
||
BALB/cAnNBdf | Adrenal gland - Cortex hyperplasia | Adrenal gland - Cortex |
40 |
||
RFM/Un | Adrenal gland - Cortex tumor | Adrenal gland - Cortex |
1 |
||
BALB/cAnNBdf | Adrenal gland - Cortex tumor | Adrenal gland - Cortex |
29 |
||
RFM/Un | Blood hyperplasia | Blood |
33 |
||
BALB/cAnNBdf | Blood hyperplasia | Blood |
37 |
||
RFM/Un | Blood vessel tumor | Blood vessel |
1 |
||
BALB/cAnNBdf | Blood vessel tumor | Blood vessel |
5 |
||
RFM/Un | Eye - Harderian gland tumor | Eye - Harderian gland |
3 |
||
BALB/cAnNBdf | Eye - Harderian gland tumor | Eye - Harderian gland |
11 |
||
RF/Un | Eye - Harderian gland tumor | Eye - Harderian gland |
0 - very low |
||
RFM/Un | Gastrointestinal tract tumor | Gastrointestinal tract |
1 |
||
BALB/cAnNBdf | Gastrointestinal tract tumor | Gastrointestinal tract |
4 |
||
RFM/Un | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0 |
||
BALB/cAnNBdf | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
1 |
||
RF/Un | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0 - 3 |
||
RFM/Un | Leukocyte lymphoma | Thymus |
8 |
||
BALB/cAnNBdf | Leukocyte lymphoma | Thymus |
1 |
||
RF/Un | Leukocyte lymphoma | Thymus |
3 - 15 |
||
RFM/Un | Leukocyte lymphoma - blast cell | Leukocyte |
observed |
||
BALB/cAnNBdf | Leukocyte lymphoma - blast cell | Leukocyte |
observed |
||
RFM/Un | Leukocyte lymphoma - lymphosarcoma | Leukocyte |
observed |
||
BALB/cAnNBdf | Leukocyte lymphoma - lymphosarcoma | Leukocyte |
observed |
||
RFM/Un | Leukocyte neoplasm | Leukocyte |
78 |
||
BALB/cAnNBdf | Leukocyte neoplasm | Leukocyte |
67 |
||
RF/Un | Leukocyte neoplasm | Leukocyte |
37 - 68 |
||
RFM/Un | Lung adenoma | Lung |
observed |
||
BALB/cAnNBdf | Lung adenoma | Lung |
observed |
||
RFM/Un | Lung carcinoma | Lung |
observed |
||
BALB/cAnNBdf | Lung carcinoma | Lung |
observed |
||
RFM/Un | Lung tumor | Lung |
26 |
||
BALB/cAnNBdf | Lung tumor | Lung |
32 |
||
RF/Un | Lung tumor | Lung |
17 - 37 |
||
RFM/Un | Mammary gland carcinoma | Mammary gland |
0 |
||
BALB/cAnNBdf | Mammary gland carcinoma | Mammary gland |
13 |
||
RFM/Un | Mammary gland hyperplasia | Mammary gland |
39 |
||
BALB/cAnNBdf | Mammary gland hyperplasia | Mammary gland |
27 |
||
RF/Un | Mammary gland tumor | Mammary gland |
1 - very low |
||
RFM/Un | Myoepithelial cell myoepithelioma | Myoepithelial cell |
0 |
||
BALB/cAnNBdf | Myoepithelial cell myoepithelioma | Myoepithelial cell |
3 |
||
RFM/Un | Ovary cyst | Ovary |
9 |
||
BALB/cAnNBdf | Ovary cyst | Ovary |
8 |
||
RFM/Un | Ovary tumor | Ovary |
1 |
||
BALB/cAnNBdf | Ovary tumor | Ovary |
8 |
||
RF/Un | Ovary tumor | Ovary |
3 - 15 |
||
RFM/Un | Pituitary gland adenoma | Pituitary gland |
7 |
||
BALB/cAnNBdf | Pituitary gland adenoma | Pituitary gland |
0 |
||
RFM/Un | Pituitary gland tumor | Pituitary gland |
1 - 7 |
||
BALB/cAnNBdf | Pituitary gland tumor | Pituitary gland |
8 |
||
RF/Un | Pituitary gland tumor | Pituitary gland |
0 - very low |
||
RFM/Un | Uterus hyperplasia | Uterus |
87 |
||
BALB/cAnNBdf | Uterus hyperplasia | Uterus |
62 |
||
RFM/Un | Uterus tumor | Uterus |
3 |
||
BALB/cAnNBdf | Uterus tumor | Uterus |
3 |
||
RFM/Un | (Unspecified organ) neoplasm | (Unspecified organ) |
88 |
||
BALB/cAnNBdf | (Unspecified organ) neoplasm | (Unspecified organ) |
94 |
||
RFM/Un | (Unspecified organ) reticulum cell sarcoma | (Unspecified organ) |
67 |
||
BALB/cAnNBdf | (Unspecified organ) reticulum cell sarcoma | (Unspecified organ) |
61 |
||
RF/Un | (Unspecified organ) reticulum cell sarcoma | (Unspecified organ) |
22 - 56 |
||
RF/Un | (Unspecified organ) tumor | (Unspecified organ) |
66 - 72 |
||
RFM/Un | (Unspecified organ) tumor - unclassified | (Unspecified organ) |
3 |
||
BALB/cAnNBdf | (Unspecified organ) tumor - unclassified | (Unspecified organ) |
4 |