Reference SummaryBooth CJ, Lab Anim Sci 1995 Oct;45(5):497-502

Title

Hemangiomas and hemangiosarcomas in inbred laboratory mice.

Authors

Booth CJ; Sundberg JP

Journal

Lab Anim Sci

Volume

Issue

Year

1995

Pages

497-502

Abstract

Hemangiomas and hemangiosarcomas are rare, naturally developing tumors of blood vessels. In a retrospective study covering a period of 57 contiguous months between 1986 and 1991, four cavernous hemangiomas, eight capillary hemangiomas, and three hemangiosarcomas developed spontaneously in A/J, BALB/cJ, BALB/cByJ, C57BL/6J, NU/J, and 129/SvJ inbred mouse strains. When data were correlated to actual numbers of each sex in the colony, no sexual dimorphism was determined. At the time of submission, mice ranged in age from 100 to 434 days, with a mean of 217 days. Tumors principally affected the skin but were also diagnosed in the seminal vesicles, liver, muscle tissue, and cerebellum. Immunohistochemistry, with antisera directed against human von Willebrand factor (factor VIII-related antigen) as an endothelial cell marker, labeled mouse endothelial cells inconsistently. A monoclonal antibody directed against the smooth muscle actin isoform, but not the sarcomeric muscle actin isoform, outlined vascular structures in tumors and normal vascular smooth muscle in adjacent normal tissues.

Links

J:30363 – MGI References
8569146 – National Library of Medicine/PubMed

Strain Notes

Strain	Note
129X1/SvJ	These mice were from the Jackson Laboratory.
A/J	These mice were from the Jackson Laboratory.
BALB/cByJ	These mice were from the Jackson Laboratory.
BALB/cJ	These mice were from the Jackson Laboratory.
C57BL/6J	These mice were from the Jackson Laboratory.
NU/J	Referred to as "inbred". The genotype of these mice with regards to the Foxn1^nu locus was not specified. These mice were from the Jackson Laboratory.

Models
Strain	Model Name	Organ Affected	Frequency
BALB/cJ	Blood vessel hemangioma - capillary	Blood vessel	observed
C57BL/6J	Blood vessel hemangioma - capillary	Blood vessel	observed
C57BL/6J	Blood vessel hemangioma - capillary	Liver	observed
A/J	Blood vessel hemangioma - cavernous	Blood vessel	observed
BALB/cByJ	Blood vessel hemangioma - cavernous	Seminal vesicle	observed
NU/J	Blood vessel hemangioma - cavernous	Blood vessel	observed
BALB/cJ	Blood vessel hemangiosarcoma	CNS - Brain - Cerebellum	observed
BALB/cJ	Blood vessel hemangiosarcoma	Blood vessel	observed
129X1/SvJ	Blood vessel hemangiosarcoma	Blood vessel	observed