Reference SummaryGroch KM, Int J Radiat Biol 1997 Mar;71(3):301-8
Title |
Lung cancer response following inhaled radon in the A/J and C57BL/6J mouse. | ||||||
Authors |
Groch KM; Khan MA; Brooks AL; Saffer JD | ||||||
Journal |
Int J Radiat Biol | ||||||
Volume |
71 | ||||||
Issue |
3 | ||||||
Year |
1997 | ||||||
Pages |
301-8 | ||||||
Abstract |
A/J and C57BL/6J mice, strains which differ in susceptibility to chemical-induced lung tumours, were examined for differential sensitivity to radon-induced lung cancer. Sixty weeks after exposure to 952 WLM radon (3.34 J h1 m-3), no lung tumours were found in the control, sham- (one dust-) exposed, or radon-exposed C57BL/6J mice. In contrast, each of the A/J groups had a substantial number of tumours. Although there were no differences in overall lung tumour incidence or multiplicity associated with radon and ore dust exposure in A/J mice, distinct differences in tumour size and histopathological appearance were noted. The ratio of lung adenoma-to-carcinoma found in control A/J mice was 10:1, whereas the ratio in one dust-exposed animals was 10:8 and that in radon-exposed animals was 8:6. Based on these data, particulates appear to modify the promotion-progression of lung cancer in this strain. In addition, the appearance of two very large carcinomas histologically resembling Clara-cell-derived tumours only in the radon-exposed A/J mice and the possibility of alpha-particle-induced killing of target cells in the radon-exposed animals suggests that A/J but not the C57BL/6J, mice may have genes that modify susceptibility to radon-induced lung cancer. | ||||||
Links |
J:39931 – MGI References 9134020 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
A/J | Lung - Club cell carcinoma |
|
Lung - Club cell |
11 |
|
A/J | Lung adenoma | Lung |
observed |
||
A/J | Lung adenoma |
|
Lung |
observed |
|
A/J | Lung adenoma |
|
Lung |
observed |
|
A/J | Lung carcinoma | Lung |
observed |
||
A/J | Lung carcinoma |
|
Lung |
observed |
|
A/J | Lung carcinoma |
|
Lung |
observed |
|
A/J | Lung hyperplasia |
|
Lung |
observed - 10 |
|
A/J | Lung hyperplasia | Lung |
observed |
||
A/J | Lung hyperplasia |
|
Lung |
observed |
|
A/J | Lung tumor |
|
Lung |
0 - 60 |
|
A/J | Lung tumor |
|
Lung |
10 - 72 |
|
A/J | Lung tumor |
|
Lung |
100 |
|
C57BL/6J | Lung tumor |
|
Lung |
0 |
|
C57BL/6J | Lung tumor |
|
Lung |
0 |
|
C57BL/6J | Lung tumor |
|
Lung |
60 |
|
A/J | Lung tumor | Lung |
64 |
||
C57BL/6J | Lung tumor | Lung |
0 |