Reference SummaryPravtcheva DD, J Exp Zool 1998 May 1;281(1):43-57

Title

Metastasizing mammary carcinomas in H19 enhancers-Igf2 transgenic mice.

Authors

Pravtcheva DD; Wise TL

Journal

J Exp Zool

Volume

281

Issue

1

Year

1998

Pages

43-57

Abstract

The insulin-like growth factor II is mitogenic for a number of cell types and can inhibit apoptosis. The frequent expression of this gene in human and experimental animal tumors indicates that insulin-like growth factor-2 may play an important role in tumor development. It has also been hypothesized that overexpression of this growth factor may be responsible for the increased incidence of childhood tumors in patients with Beckwith-Wiedemann syndrome. To assess the effects of Igf2 on tumor development we produced six transgenic mouse lines that express the gene under the control of the H19 enhancers. Transgenic expression was initiated in the embryonic period but remained high in several adult tissues, including the mammary gland, lung, and liver. Adult transgenic females from five of the transgenic lines developed often multiple mammary tumors that had the ability to metastasize. Increased incidence of other solid tumors was also noted in older mice. These findings indicate that Igf2 expression increases the probability of malignant transformation and that the mammary gland is at a particularly high risk of tumor development in response to chronic increase in Igf2 gene dosage.

Links

J:47190 – MGI References
9571768 – National Library of Medicine/PubMed

Strain Notes

Strain Note
FVB/N These mice included FVB/N inbred mice and nontransgenic littermates.

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
FVB/N-Tg(Rr28-Igf2)#Ddp Adipose tissue lipoma Adipose tissue

5.3

FVB/N-Tg(Igf2-LacZ)#Ddp Lung tumor Lung

10

FVB/N-Tg(Rr28-Igf2)#Ddp Lung tumor Lung

42

FVB/N-Tg(Rr28-Igf2)1bDdp Mammary gland adenocarcinoma - type A Mammary gland

observed

FVB/N-Tg(Rr28-Igf2)1Ddp Mammary gland adenocarcinoma - type B Mammary gland

100

FVB/N-Tg(Rr28-Igf2)1aDdp Mammary gland adenoma Mammary gland

observed

FVB/N-Tg(Rr28-Igf2)10aDdp Mammary gland foci Mammary gland

observed

FVB/N Mammary gland foci Mammary gland

0

FVB/N-Tg(Rr28-Igf2)#Ddp Mammary gland foci Mammary gland

50

FVB/N-Tg(Rr28-Igf2)1aDdp Mammary gland hyperplasia - alveolar Mammary gland

0

FVB/N-Tg(Rr28-Igf2)2Ddp Mammary gland hyperplasia - alveolar Mammary gland

0

FVB/N Mammary gland hyperplasia - alveolar Mammary gland

0

FVB/N-Tg(Rr28-Igf2)1aDdp Mammary gland tumor Mammary gland

observed - 81

FVB/N-Tg(Rr28-Igf2)1bDdp Mammary gland tumor Mammary gland

50

FVB/N-Tg(Rr28-Igf2)10aDdp Mammary gland tumor Mammary gland

observed - 64

FVB/N-Tg(Rr28-Igf2)10bDdp Mammary gland tumor Mammary gland

observed

FVB/N-Tg(Rr28-Igf2)2Ddp Mammary gland tumor Mammary gland

observed - 100

FVB/N-Tg(Igf2-LacZ)#Ddp Mammary gland tumor Mammary gland

4.8

FVB/N Mammary gland tumor Mammary gland

0

FVB/N-Tg(Rr28-Igf2)#Ddp Mammary gland tumor Mammary gland

observed