Reference SummaryPapanikolaou A, Cancer Lett 1998 Aug 14;130(1-2):29-34
Title |
Azoxymethane-induced colon tumors and aberrant crypt foci in mice of different genetic susceptibility. | ||||||||
Authors |
Papanikolaou A; Wang QS; Delker DA; Rosenberg DW | ||||||||
Journal |
Cancer Lett | ||||||||
Volume |
130 | ||||||||
Issue |
1-2 | ||||||||
Year |
1998 | ||||||||
Pages |
29-34 | ||||||||
Abstract |
Azoxymethane (AOM) is an organotropic colon carcinogen that is commonly used to induce colon tumors in rodents. Unlike its parent compound, 1,2-dimethylhydrazine (DMH), a tumor susceptibility phenotype in inbred mice with respect to AOM has not been established. Thus, this study was undertaken to determine whether genetic susceptibility extends to this carcinogen. SWR/J, A/J (both susceptible to DMH carcinogenesis) and AKR/J (resistant) mice were treated with 10 mg/kg AOM i.p. once a week for 8 weeks. Twenty-five weeks after the initial injection, tumor yield was determined. With a single exception, only SWR/J and A/J mice developed tumors, with a distribution that was limited to the distal colon (16.3+/-1.1 and 36.4+/-2.4. respectively). The formation of aberrant crypt foci (ACF), putative preneoplastic lesions, was also assessed in whole-mount colons using Methylene Blue staining. Consistent with tumor multiplicity, the total number of ACF was highest in A/J mice, followed by SWR/J mice. In addition, A/J mice had a significantly greater number of large ACF (five or more crypts per foci) than the other strains. Despite the absence of colon tumors, however, AKR/J mice did develop a significant number of ACF. This finding suggests that ACF in resistant mice are persistent but do not progress to tumors. | ||||||||
Links |
J:49937 – MGI References 9751253 – National Library of Medicine/PubMed |
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Strain Notes
|
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| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| SWR/J | Intestine - Large Intestine - Colon - Distal adenocarcinoma |
|
Intestine - Large Intestine - Colon - Distal |
observed |
|
| AKR/J | Intestine - Large Intestine - Colon - Distal adenoma |
|
Intestine - Large Intestine - Colon - Distal |
13 |
|
| AKR/J | Intestine - Large Intestine - Colon - Distal adenoma | Intestine - Large Intestine - Colon - Distal |
0 |
||
| A/J | Intestine - Large Intestine - Colon - Distal adenoma - polypoid |
|
Intestine - Large Intestine - Colon - Distal |
observed |
|
| SWR/J | Intestine - Large Intestine - Colon - Distal foci - aberrant crypt (ACF) |
|
Intestine - Large Intestine - Colon - Distal |
observed |
|
| SWR/J | Intestine - Large Intestine - Colon - Distal foci - aberrant crypt (ACF) | Intestine - Large Intestine - Colon - Distal |
0 |
||
| A/J | Intestine - Large Intestine - Colon - Distal foci - aberrant crypt (ACF) | Intestine - Large Intestine - Colon - Distal |
0 |
||
| A/J | Intestine - Large Intestine - Colon - Distal foci - aberrant crypt (ACF) |
|
Intestine - Large Intestine - Colon - Distal |
observed |
|
| AKR/J | Intestine - Large Intestine - Colon - Distal foci - aberrant crypt (ACF) |
|
Intestine - Large Intestine - Colon - Distal |
observed |
|
| AKR/J | Intestine - Large Intestine - Colon - Distal foci - aberrant crypt (ACF) | Intestine - Large Intestine - Colon - Distal |
0 |
||
| SWR/J | Intestine - Large Intestine - Colon - Distal tumor |
|
Intestine - Large Intestine - Colon - Distal |
observed |
|
| SWR/J | Intestine - Large Intestine - Colon - Distal tumor | Intestine - Large Intestine - Colon - Distal |
0 |
||
| A/J | Intestine - Large Intestine - Colon - Distal tumor | Intestine - Large Intestine - Colon - Distal |
0 |
||
| A/J | Intestine - Large Intestine - Colon - Distal tumor |
|
Intestine - Large Intestine - Colon - Distal |
observed |
|
| SWR/J | Intestine - Large Intestine - Colon - Proximal tumor |
|
Intestine - Large Intestine - Colon - Proximal |
0 |
|
| SWR/J | Intestine - Large Intestine - Colon - Proximal tumor | Intestine - Large Intestine - Colon - Proximal |
0 |
||
| A/J | Intestine - Large Intestine - Colon - Proximal tumor | Intestine - Large Intestine - Colon - Proximal |
0 |
||
| A/J | Intestine - Large Intestine - Colon - Proximal tumor |
|
Intestine - Large Intestine - Colon - Proximal |
0 |
|
| AKR/J | Intestine - Large Intestine - Colon - Proximal tumor |
|
Intestine - Large Intestine - Colon - Proximal |
0 |
|
| AKR/J | Intestine - Large Intestine - Colon - Proximal tumor | Intestine - Large Intestine - Colon - Proximal |
0 |
||
| SWR/J | Intestine - Small Intestine tumor |
|
Intestine - Small Intestine |
0 |
|
| SWR/J | Intestine - Small Intestine tumor | Intestine - Small Intestine |
0 |
||
| A/J | Intestine - Small Intestine tumor | Intestine - Small Intestine |
0 |
||
| A/J | Intestine - Small Intestine tumor |
|
Intestine - Small Intestine |
0 |
|
| AKR/J | Intestine - Small Intestine tumor |
|
Intestine - Small Intestine |
0 |
|
| AKR/J | Intestine - Small Intestine tumor | Intestine - Small Intestine |
0 |
||
| SWR/J | Kidney tumor |
|
Kidney |
0 |
|
| SWR/J | Kidney tumor | Kidney |
0 |
||
| A/J | Kidney tumor | Kidney |
0 |
||
| A/J | Kidney tumor |
|
Kidney |
0 |
|
| AKR/J | Kidney tumor |
|
Kidney |
0 |
|
| AKR/J | Kidney tumor | Kidney |
0 |
||
| SWR/J | Liver tumor |
|
Liver |
0 |
|
| SWR/J | Liver tumor | Liver |
0 |
||
| A/J | Liver tumor | Liver |
0 |
||
| A/J | Liver tumor |
|
Liver |
0 |
|
| AKR/J | Liver tumor |
|
Liver |
0 |
|
| AKR/J | Liver tumor | Liver |
0 |