Reference SummaryFukutake M, Carcinogenesis 1998 Nov;19(11):1939-42

Title

 Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice.

Authors

 Fukutake M; Nakatsugi S; Isoi T; Takahashi M; Ohta T; Mamiya S; Taniguchi Y; Sato H; Fukuda K; Sugimura T; Wakabayashi K

Journal

 Carcinogenesis

Volume

 19

Issue

 11

Year

 1998

Pages

 1939-42

Abstract

 The effects of nimesulide, a selective inhibitor of cyclooxygenase-2 (COX-2) on azoxymethane (AOM)-induced colon carcinogenesis were investigated in mice. AOM at a dose of 10 mg/kg body wt was administered to male ICR mice once a week for 6 weeks. The animals were fed on AIN-76A powder diet containing nimesulide at doses of 200 or 400 p.p.m., starting the day before the first carcinogen treatment until the end of the experiment, at week 30. Administration of nimesulide reduced the incidence of colon carcinomas to 32 and 25% for the AOM + 200 and 400 p.p.m. nimesulide groups, respectively, compared with the AOM + basal diet group (50%). Multiplicities of colon carcinomas in the 200 and 400 p.p.m. nimesulide-treated groups were 0.70 +/- 0.28 and 0.35 +/- 0.11, respectively, being significantly smaller than the AOM alone value (1.79 +/- 0.47). The sizes of the colon carcinomas in the nimesulide-treated groups were also decreased. No significant influence on liver and lung tumor development was apparent. Thus, nimesulide exerted a suppressive effect on AOM-induced colon carcinogenesis in mice.

Links

 J:51244 – MGI References
9855006 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
ICR Intestine - Large Intestine - Colon - Distal carcinoma
  • azoxymethane (AOM)
 Intestine - Large Intestine - Colon - Distal

observed
ICR Intestine - Large Intestine - Colon - Distal carcinoma
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
  • azoxymethane (AOM)
 Intestine - Large Intestine - Colon - Distal

observed
ICR Intestine - Large Intestine - Colon - Medial carcinoma
  • azoxymethane (AOM)
 Intestine - Large Intestine - Colon - Medial

observed
ICR Intestine - Large Intestine - Colon - Medial carcinoma
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
  • azoxymethane (AOM)
 Intestine - Large Intestine - Colon - Medial

observed
ICR Intestine - Large Intestine - Colon - Proximal carcinoma
  • azoxymethane (AOM)
 Intestine - Large Intestine - Colon - Proximal

0
ICR Intestine - Large Intestine - Colon - Proximal carcinoma
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
  • azoxymethane (AOM)
 Intestine - Large Intestine - Colon - Proximal

0
ICR Intestine - Large Intestine - Rectum carcinoma
  • azoxymethane (AOM)
 Intestine - Large Intestine - Rectum

observed
ICR Intestine - Large Intestine - Rectum carcinoma
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
  • azoxymethane (AOM)
 Intestine - Large Intestine - Rectum

observed
ICR Intestine - Large Intestine carcinoma
  • azoxymethane (AOM)
 Intestine - Large Intestine

50
ICR Intestine - Large Intestine carcinoma
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
  • azoxymethane (AOM)
 Intestine - Large Intestine

25 - 32
ICR Intestine - Large Intestine tumor Intestine - Large Intestine

0
ICR Intestine - Large Intestine tumor
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
 Intestine - Large Intestine

0
ICR Liver tumor
  • azoxymethane (AOM)
 Liver

32
ICR Liver tumor
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
  • azoxymethane (AOM)
 Liver

27 - 30
ICR Lung adenoma
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
 Lung

5
ICR Lung tumor
  • azoxymethane (AOM)
 Lung

29
ICR Lung tumor
  • nimesulide (4-nitro-2-phenoxymethanesulfonanilide)
  • azoxymethane (AOM)
 Lung

35 - 42.5