Reference SummaryCarlton PS, Cancer Lett 2000 Oct 31;159(2):113-7

Title

Failure of dietary lyophilized strawberries to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-and benzo[a]pyrene-induced lung tumorigenesis in strain A/J mice

Authors

Carlton PS; Kresty LA; Stoner GD

Journal

Cancer Lett

Volume

159

Issue

2

Year

2000

Pages

113-7

Abstract

In the present study, we examined the ability of lyophilized strawberries in the diet to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- and benzo[a]pyrene (B[a]P)-induced lung tumorigenesis in the A/J mouse. Groups of 20 mice were administered purified AIN-76A diet containing 10% lyophilized strawberries 1 week before carcinogen dosing, and for the duration of the study. NNK was administered by i.p. injection in five, 0.414 mg doses. B[a]P was administered by gavage in five, 0.2 mg doses. At 20 weeks, there were no significant differences in tumor incidence or tumor multiplicity between the NNK+10% lyophilized strawberry group and the NNK control group. Similarly, at 24 weeks, there were no differences in tumorigenesis between the B[a]P+10% lyophilized strawberry group and the B[a]P control group. Therefore, lyophilized strawberries at 10% in the diet failed to inhibit NNK- and B[a]P-induced mouse lung tumorigenesis.

Links

J:64662 – MGI References
10996721 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
A/J Lung adenoma Lung

11 - 50

A/J Lung adenoma
  • lyophilized strawberries
Lung

20 - 30

A/J Lung adenoma
  • 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
Lung

60 - 100

A/J Lung adenoma
  • 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
  • lyophilized strawberries
Lung

95

A/J Lung adenoma
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
Lung

20 - 74

A/J Lung adenoma
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
  • lyophilized strawberries
Lung

79