Reference SummaryCarlton PS, Cancer Lett 2000 Oct 31;159(2):113-7
Title |
Failure of dietary lyophilized strawberries to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-and benzo[a]pyrene-induced lung tumorigenesis in strain A/J mice |
Authors |
Carlton PS; Kresty LA; Stoner GD |
Journal |
Cancer Lett |
Volume |
159 |
Issue |
2 |
Year |
2000 |
Pages |
113-7 |
Abstract |
In the present study, we examined the ability of lyophilized strawberries in the diet to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- and benzo[a]pyrene (B[a]P)-induced lung tumorigenesis in the A/J mouse. Groups of 20 mice were administered purified AIN-76A diet containing 10% lyophilized strawberries 1 week before carcinogen dosing, and for the duration of the study. NNK was administered by i.p. injection in five, 0.414 mg doses. B[a]P was administered by gavage in five, 0.2 mg doses. At 20 weeks, there were no significant differences in tumor incidence or tumor multiplicity between the NNK+10% lyophilized strawberry group and the NNK control group. Similarly, at 24 weeks, there were no differences in tumorigenesis between the B[a]P+10% lyophilized strawberry group and the B[a]P control group. Therefore, lyophilized strawberries at 10% in the diet failed to inhibit NNK- and B[a]P-induced mouse lung tumorigenesis. |
Links |
J:64662 – MGI References 10996721 – National Library of Medicine/PubMed |
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
A/J | Lung adenoma | Lung |
11 - 50 |
||
A/J | Lung adenoma |
|
Lung |
20 - 30 |
|
A/J | Lung adenoma |
|
Lung |
60 - 100 |
|
A/J | Lung adenoma |
|
Lung |
95 |
|
A/J | Lung adenoma |
|
Lung |
20 - 74 |
|
A/J | Lung adenoma |
|
Lung |
79 |