Reference SummaryImai S, J Natl Cancer Inst 1983 Sep;71(3):517-21
Title |
A new locus (Mtv-4) for endogenous mammary tumor virus expression and early mammary tumor development in the SHN mouse strain. | ||||||||||||||
Authors |
Imai S; Tsubura Y; Hilgers J; Michalides R | ||||||||||||||
Journal |
J Natl Cancer Inst | ||||||||||||||
Volume |
71 | ||||||||||||||
Issue |
3 | ||||||||||||||
Year |
1983 | ||||||||||||||
Pages |
517-21 | ||||||||||||||
Abstract |
The SHN mouse strain, which has a high incidence of mammary cancer, developed by inbreeding and selection from Swiss stock mice by Dr. H. Nagasawa and co-workers (Meiji University, Tokyo, Japan), harbored an endogenous mammary tumor virus (MTV) responsible for a high frequency of mammary tumors early in life. The locus was called Mtv-4 and was only comparable with Mtv-2 of the GR mouse strain in its inducing capacity of mammary cancer. Molecular hybridization with 32P-labeled MTV complementary DNA showed that the characteristic Mtv-2 bands of the GR strain were absent in the SHN strain. | ||||||||||||||
Links |
J:7178 – MGI References 6310199 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
BALB/c | Mammary gland adenoacanthoma | Mammary gland |
2.9 |
||
C;SHN-Mtv4a | Mammary gland adenoacanthoma - pale cell type | Mammary gland |
0 |
||
(BALB/c x DD)F1 | Mammary gland adenoacanthoma - pale cell type | Mammary gland |
0 |
||
(BALB/c x SHN)F1-Mtv4a | Mammary gland adenoacanthoma - pale cell type | Mammary gland |
0 |
||
DD/Tbr | Mammary gland adenoacanthoma - pale cell type |
|
Mammary gland |
0 |
|
SHN | Mammary gland adenoacanthoma - pale cell type | Mammary gland |
0 |
||
SHNfBALB/c | Mammary gland adenoacanthoma - pale cell type | Mammary gland |
0 |
||
C;SHN | Mammary gland adenoacanthoma - pale cell type | Mammary gland |
0 |
||
C;SHN-Mtv4a | Mammary gland adenocarcinoma | Mammary gland |
83 |
||
C;SHN | Mammary gland adenocarcinoma | Mammary gland |
14 |
||
(BALB/c x DD)F1 | Mammary gland adenocarcinoma | Mammary gland |
17 |
||
(BALB/c x SHN)F1-Mtv4a | Mammary gland adenocarcinoma | Mammary gland |
95 |
||
DD/Tbr | Mammary gland adenocarcinoma |
|
Mammary gland |
71 |
|
SHN | Mammary gland adenocarcinoma | Mammary gland |
92 |
||
SHNfBALB/c | Mammary gland adenocarcinoma | Mammary gland |
89 |
||
DDfBALB/c | Mammary gland tumor | Mammary gland |
0 |