Reference SummaryImai S, J Natl Cancer Inst 1983 Sep;71(3):517-21

Title

A new locus (Mtv-4) for endogenous mammary tumor virus expression and early mammary tumor development in the SHN mouse strain.

Authors

Imai S; Tsubura Y; Hilgers J; Michalides R

Journal

J Natl Cancer Inst

Volume

71

Issue

3

Year

1983

Pages

517-21

Abstract

The SHN mouse strain, which has a high incidence of mammary cancer, developed by inbreeding and selection from Swiss stock mice by Dr. H. Nagasawa and co-workers (Meiji University, Tokyo, Japan), harbored an endogenous mammary tumor virus (MTV) responsible for a high frequency of mammary tumors early in life. The locus was called Mtv-4 and was only comparable with Mtv-2 of the GR mouse strain in its inducing capacity of mammary cancer. Molecular hybridization with 32P-labeled MTV complementary DNA showed that the characteristic Mtv-2 bands of the GR strain were absent in the SHN strain.

Links

J:7178 – MGI References
6310199 – National Library of Medicine/PubMed

Strain Notes

Strain Note
(BALB/c x SHN)F1-Mtv4a Carrier of MMTV via Mtv4.
C;SHN Does NOT carry endogenous MMTV via Mtv4 from the SHN strain.
C;SHN-Mtv4a Carrier of MMTV via Mtv4 from the SHN strain.
DDfBALB/c Mice were NOT carriers of infectious MMTV.
DD/Tbr Mice were carriers of infectious MMTV.
SHNfBALB/c Carrier of MMTV via Mtv4.

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
BALB/c Mammary gland adenoacanthoma Mammary gland

2.9

C;SHN-Mtv4a Mammary gland adenoacanthoma - pale cell type Mammary gland

0

(BALB/c x DD)F1 Mammary gland adenoacanthoma - pale cell type Mammary gland

0

(BALB/c x SHN)F1-Mtv4a Mammary gland adenoacanthoma - pale cell type Mammary gland

0

DD/Tbr Mammary gland adenoacanthoma - pale cell type
  • MMTV - mouse mammary tumor virus
Mammary gland

0

SHN Mammary gland adenoacanthoma - pale cell type Mammary gland

0

SHNfBALB/c Mammary gland adenoacanthoma - pale cell type Mammary gland

0

C;SHN Mammary gland adenoacanthoma - pale cell type Mammary gland

0

C;SHN-Mtv4a Mammary gland adenocarcinoma Mammary gland

83

C;SHN Mammary gland adenocarcinoma Mammary gland

14

(BALB/c x DD)F1 Mammary gland adenocarcinoma Mammary gland

17

(BALB/c x SHN)F1-Mtv4a Mammary gland adenocarcinoma Mammary gland

95

DD/Tbr Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
Mammary gland

71

SHN Mammary gland adenocarcinoma Mammary gland

92

SHNfBALB/c Mammary gland adenocarcinoma Mammary gland

89

DDfBALB/c Mammary gland tumor Mammary gland

0