Reference SummaryYamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Title

Independent variation in susceptibilities of six different mouse strains to induction of pepsinogen-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosourea.

Authors

Yamamoto M; Furihata C; Ogiu T; Tsukamoto T; Inada K; Hirano K; Tatematsu M

Journal

Cancer Lett

Volume

179

Issue

2

Year

2002

Pages

121-32

Abstract

Strain differences in susceptibility regarding stomach carcinogenesis due to N-methyl-N-nitrosourea were examined in males of six strains of mice: BALB/cA (BALB), C57BL/6N (C57BL6), CBA/JN (CBA), C3H/HeN (C3H), DBA/2N (DBA/2), and CD-1 (ICR). The frequency of pepsinogen-altered pyloric glands (PAPGs), putative precancerous lesions, was highest (19.6plus minus9.9%) in the BALB and lowest in the ICR (12.3plus minus5.7%) mice (P<0.05). Incidences of adenocarcinomas at week 52 were 59.3% (16 of 27) and 18.5% (5 of 27), respectively (P<0.005). Invasion also tended to be deepest in BALB compared with the other strains. Intestinal alkaline phosphatase-positive intestinal type cells were observed heterogeneously in some hyperplasias, adenomas and adenocarcinomas consisting of gastric type cells. Thus, intestinalization appeared to occur at random in both non-neoplastic and monoclonal neoplastic lesions, making it unlikely that IAP-positive cells could be precursors of gastric tumors. In contrast, the data suggest a direct histogenetic role for the PAPG, a useful preneoplastic marker lesion in mouse strains.

Links

J:75233 – MGI References
11888666 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
BALB Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Spleen

41.4

BALB Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Liver

0

BALB Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Intestine

6.9

C57BL/6N Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Spleen

13.0

C57BL/6N Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Liver

8.7

C57BL/6N Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Intestine

34.8

CBA/JN Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Spleen

3.8

CBA/JN Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Liver

3.8

CBA/JN Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Intestine

3.8

C3H Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Spleen

39.3

C3H Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Liver

0

C3H Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Intestine

3.6

DBA/2N Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Spleen

16.7

DBA/2N Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Liver

0

DBA/2N Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Intestine

3.3

CD-1 Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Spleen

25.9

CD-1 Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Liver

3.7

CD-1 Blood vessel hemangiosarcoma
  • N-methyl-N-nitrosourea (MNU)
Intestine

14.8

BALB Intestine adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Intestine

6.9

C57BL/6N Intestine adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Intestine

17.4

CBA/JN Intestine adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Intestine

23.1

C3H Intestine adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Intestine

0

DBA/2N Intestine adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Intestine

0

CD-1 Intestine adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Intestine

0

CBA/JN Intestine adenoma
  • N-methyl-N-nitrosourea (MNU)
Intestine

observed

BALB Intestine metaplasia
  • N-methyl-N-nitrosourea (MNU)
Intestine

0

BALB Intestine metaplasia Intestine

0

C57BL/6N Intestine metaplasia
  • N-methyl-N-nitrosourea (MNU)
Intestine

0

C57BL/6N Intestine metaplasia Intestine

0

CBA/JN Intestine metaplasia
  • N-methyl-N-nitrosourea (MNU)
Intestine

0

CBA/JN Intestine metaplasia Intestine

0

C3H Intestine metaplasia
  • N-methyl-N-nitrosourea (MNU)
Intestine

0

C3H Intestine metaplasia Intestine

0

DBA/2N Intestine metaplasia
  • N-methyl-N-nitrosourea (MNU)
Intestine

0

DBA/2N Intestine metaplasia Intestine

0

CD-1 Intestine metaplasia
  • N-methyl-N-nitrosourea (MNU)
Intestine

0

CD-1 Intestine metaplasia Intestine

0

CBA/JN Intestine tumor
  • N-methyl-N-nitrosourea (MNU)
Intestine

observed

BALB Leukocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Spleen

20.7

BALB Leukocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Thymus

6.9

C57BL/6N Leukocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Spleen

0

C57BL/6N Leukocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Thymus

0

CBA/JN Leukocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Spleen

11.5

CBA/JN Leukocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Thymus

3.8

C3H Leukocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Spleen

3.6

C3H Leukocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Thymus

3.6

DBA/2N Leukocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Spleen

3.3

DBA/2N Leukocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Thymus

3.3

CD-1 Leukocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Spleen

0

CD-1 Leukocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Thymus

7.4

BALB Liver hepatocellular carcinoma
  • N-methyl-N-nitrosourea (MNU)
Liver

0

C57BL/6N Liver hepatocellular carcinoma
  • N-methyl-N-nitrosourea (MNU)
Liver

0

CBA/JN Liver hepatocellular carcinoma
  • N-methyl-N-nitrosourea (MNU)
Liver

3.8

C3H Liver hepatocellular carcinoma
  • N-methyl-N-nitrosourea (MNU)
Liver

17.9

DBA/2N Liver hepatocellular carcinoma
  • N-methyl-N-nitrosourea (MNU)
Liver

0

CD-1 Liver hepatocellular carcinoma
  • N-methyl-N-nitrosourea (MNU)
Liver

0

BALB Lung adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Lung

48.3

C57BL/6N Lung adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Lung

4.3

CBA/JN Lung adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Lung

46.2

C3H Lung adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Lung

0

DBA/2N Lung adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Lung

20

CD-1 Lung adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Lung

44.4

BALB Stomach - Glandular - Pylorus hyperplasia
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

observed

C57BL/6N Stomach - Glandular - Pylorus hyperplasia
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

observed

CBA/JN Stomach - Glandular - Pylorus hyperplasia
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

observed

C3H Stomach - Glandular - Pylorus hyperplasia
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

observed

DBA/2N Stomach - Glandular - Pylorus hyperplasia
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

observed

CD-1 Stomach - Glandular - Pylorus hyperplasia
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

observed

BALB Stomach - Glandular - Pylorus hyperplasia Stomach - Glandular - Pylorus

0

C57BL/6N Stomach - Glandular - Pylorus hyperplasia Stomach - Glandular - Pylorus

0

CBA/JN Stomach - Glandular - Pylorus hyperplasia Stomach - Glandular - Pylorus

0

C3H Stomach - Glandular - Pylorus hyperplasia Stomach - Glandular - Pylorus

0

DBA/2N Stomach - Glandular - Pylorus hyperplasia Stomach - Glandular - Pylorus

0

CD-1 Stomach - Glandular - Pylorus hyperplasia Stomach - Glandular - Pylorus

0

BALB Stomach - Glandular - Pylorus lesion
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

100

C57BL/6N Stomach - Glandular - Pylorus lesion
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

100

CBA/JN Stomach - Glandular - Pylorus lesion
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

100

C3H Stomach - Glandular - Pylorus lesion
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

100

DBA/2N Stomach - Glandular - Pylorus lesion
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

100

CD-1 Stomach - Glandular - Pylorus lesion
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

100

BALB Stomach - Glandular - Pylorus lesion Stomach - Glandular - Pylorus

100

C57BL/6N Stomach - Glandular - Pylorus lesion Stomach - Glandular - Pylorus

100

CBA/JN Stomach - Glandular - Pylorus lesion Stomach - Glandular - Pylorus

100

C3H Stomach - Glandular - Pylorus lesion Stomach - Glandular - Pylorus

100

DBA/2N Stomach - Glandular - Pylorus lesion Stomach - Glandular - Pylorus

100

CD-1 Stomach - Glandular - Pylorus lesion Stomach - Glandular - Pylorus

100

BALB Stomach - Glandular - Pylorus preneoplastic lesion
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

observed

C57BL/6N Stomach - Glandular - Pylorus preneoplastic lesion
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

observed

CBA/JN Stomach - Glandular - Pylorus preneoplastic lesion
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

observed

C3H Stomach - Glandular - Pylorus preneoplastic lesion
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

observed

DBA/2N Stomach - Glandular - Pylorus preneoplastic lesion
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

observed

CD-1 Stomach - Glandular - Pylorus preneoplastic lesion
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

observed

BALB Stomach - Glandular - Pylorus preneoplastic lesion Stomach - Glandular - Pylorus

0

C57BL/6N Stomach - Glandular - Pylorus preneoplastic lesion Stomach - Glandular - Pylorus

0

CBA/JN Stomach - Glandular - Pylorus preneoplastic lesion Stomach - Glandular - Pylorus

0

C3H Stomach - Glandular - Pylorus preneoplastic lesion Stomach - Glandular - Pylorus

0

DBA/2N Stomach - Glandular - Pylorus preneoplastic lesion Stomach - Glandular - Pylorus

0

CD-1 Stomach - Glandular - Pylorus preneoplastic lesion Stomach - Glandular - Pylorus

0

BALB Stomach - Glandular - Pylorus tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

0

C57BL/6N Stomach - Glandular - Pylorus tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

0

CBA/JN Stomach - Glandular - Pylorus tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

0

C3H Stomach - Glandular - Pylorus tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

0

DBA/2N Stomach - Glandular - Pylorus tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

0

CD-1 Stomach - Glandular - Pylorus tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular - Pylorus

0

BALB Stomach - Glandular - Pylorus tumor Stomach - Glandular - Pylorus

0

C57BL/6N Stomach - Glandular - Pylorus tumor Stomach - Glandular - Pylorus

0

CBA/JN Stomach - Glandular - Pylorus tumor Stomach - Glandular - Pylorus

0

C3H Stomach - Glandular - Pylorus tumor Stomach - Glandular - Pylorus

0

DBA/2N Stomach - Glandular - Pylorus tumor Stomach - Glandular - Pylorus

0

CD-1 Stomach - Glandular - Pylorus tumor Stomach - Glandular - Pylorus

0

BALB Stomach - Glandular adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

59.3

BALB Stomach - Glandular adenocarcinoma Stomach - Glandular

0

C57BL/6N Stomach - Glandular adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

31.8

C57BL/6N Stomach - Glandular adenocarcinoma Stomach - Glandular

0

CBA/JN Stomach - Glandular adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

30.4

CBA/JN Stomach - Glandular adenocarcinoma Stomach - Glandular

0

C3H Stomach - Glandular adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

26.9

C3H Stomach - Glandular adenocarcinoma Stomach - Glandular

0

DBA/2N Stomach - Glandular adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

20.7

DBA/2N Stomach - Glandular adenocarcinoma Stomach - Glandular

0

CD-1 Stomach - Glandular adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

18.5

CD-1 Stomach - Glandular adenocarcinoma Stomach - Glandular

0

BALB Stomach - Glandular adenocarcinoma - poorly differentiated
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

3.7

C57BL/6N Stomach - Glandular adenocarcinoma - poorly differentiated
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

0

CBA/JN Stomach - Glandular adenocarcinoma - poorly differentiated
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

4.3

C3H Stomach - Glandular adenocarcinoma - poorly differentiated
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

DBA/2N Stomach - Glandular adenocarcinoma - poorly differentiated
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

3.4

CD-1 Stomach - Glandular adenocarcinoma - poorly differentiated
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

BALB Stomach - Glandular adenocarcinoma - signet ring cell
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

3.7

C57BL/6N Stomach - Glandular adenocarcinoma - signet ring cell
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

0

CBA/JN Stomach - Glandular adenocarcinoma - signet ring cell
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

0

C3H Stomach - Glandular adenocarcinoma - signet ring cell
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

0

DBA/2N Stomach - Glandular adenocarcinoma - signet ring cell
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

0

CD-1 Stomach - Glandular adenocarcinoma - signet ring cell
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

0

BALB Stomach - Glandular adenocarcinoma - well-differentiated
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

C57BL/6N Stomach - Glandular adenocarcinoma - well-differentiated
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

CBA/JN Stomach - Glandular adenocarcinoma - well-differentiated
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

C3H Stomach - Glandular adenocarcinoma - well-differentiated
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

DBA/2N Stomach - Glandular adenocarcinoma - well-differentiated
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

CD-1 Stomach - Glandular adenocarcinoma - well-differentiated
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

BALB Stomach - Glandular adenoma
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

63.0

BALB Stomach - Glandular adenoma Stomach - Glandular

0

C57BL/6N Stomach - Glandular adenoma
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

54.5

C57BL/6N Stomach - Glandular adenoma Stomach - Glandular

0

CBA/JN Stomach - Glandular adenoma
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

52.2

CBA/JN Stomach - Glandular adenoma Stomach - Glandular

0

C3H Stomach - Glandular adenoma
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

80.8

C3H Stomach - Glandular adenoma Stomach - Glandular

0

DBA/2N Stomach - Glandular adenoma
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

51.7

DBA/2N Stomach - Glandular adenoma Stomach - Glandular

0

CD-1 Stomach - Glandular adenoma
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

48.1

CD-1 Stomach - Glandular adenoma Stomach - Glandular

0

BALB Stomach - Glandular tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

BALB Stomach - Glandular tumor Stomach - Glandular

0

C57BL/6N Stomach - Glandular tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

C57BL/6N Stomach - Glandular tumor Stomach - Glandular

0

CBA/JN Stomach - Glandular tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

CBA/JN Stomach - Glandular tumor Stomach - Glandular

0

C3H Stomach - Glandular tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

C3H Stomach - Glandular tumor Stomach - Glandular

0

DBA/2N Stomach - Glandular tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

DBA/2N Stomach - Glandular tumor Stomach - Glandular

0

CD-1 Stomach - Glandular tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach - Glandular

observed

CD-1 Stomach - Glandular tumor Stomach - Glandular

0

DBA/2N Stomach adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Stomach

20.7

C3H Stomach adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Stomach

26.1

BALB Stomach adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Stomach

57.7

CD-1 Stomach adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Stomach

17.9

C57BL/6N Stomach adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Stomach

33.3

CBA/JN Stomach adenocarcinoma
  • N-methyl-N-nitrosourea (MNU)
Stomach

29.6

BALB Stomach adenocarcinoma - signet ring cell
  • N-methyl-N-nitrosourea (MNU)
Stomach

observed

C57BL/6N Stomach adenocarcinoma - well-differentiated
  • N-methyl-N-nitrosourea (MNU)
Stomach

observed

DBA/2N Stomach tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach

observed

C3H Stomach tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach

observed

BALB Stomach tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach

observed

CD-1 Stomach tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach

observed

C57BL/6N Stomach tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach

observed

CBA/JN Stomach tumor
  • N-methyl-N-nitrosourea (MNU)
Stomach

observed