Reference SummaryYamamoto M, Cancer Lett 2002 May 28;179(2):121-32
Title |
Independent variation in susceptibilities of six different mouse strains to induction of pepsinogen-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosourea. |
Authors |
Yamamoto M; Furihata C; Ogiu T; Tsukamoto T; Inada K; Hirano K; Tatematsu M |
Journal |
Cancer Lett |
Volume |
179 |
Issue |
2 |
Year |
2002 |
Pages |
121-32 |
Abstract |
Strain differences in susceptibility regarding stomach carcinogenesis due to N-methyl-N-nitrosourea were examined in males of six strains of mice: BALB/cA (BALB), C57BL/6N (C57BL6), CBA/JN (CBA), C3H/HeN (C3H), DBA/2N (DBA/2), and CD-1 (ICR). The frequency of pepsinogen-altered pyloric glands (PAPGs), putative precancerous lesions, was highest (19.6plus minus9.9%) in the BALB and lowest in the ICR (12.3plus minus5.7%) mice (P<0.05). Incidences of adenocarcinomas at week 52 were 59.3% (16 of 27) and 18.5% (5 of 27), respectively (P<0.005). Invasion also tended to be deepest in BALB compared with the other strains. Intestinal alkaline phosphatase-positive intestinal type cells were observed heterogeneously in some hyperplasias, adenomas and adenocarcinomas consisting of gastric type cells. Thus, intestinalization appeared to occur at random in both non-neoplastic and monoclonal neoplastic lesions, making it unlikely that IAP-positive cells could be precursors of gastric tumors. In contrast, the data suggest a direct histogenetic role for the PAPG, a useful preneoplastic marker lesion in mouse strains. |
Links |
J:75233 – MGI References 11888666 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| BALB | Blood vessel hemangiosarcoma |
|
Spleen |
41.4 |
|
| BALB | Blood vessel hemangiosarcoma |
|
Liver |
0 |
|
| BALB | Blood vessel hemangiosarcoma |
|
Intestine |
6.9 |
|
| C57BL/6N | Blood vessel hemangiosarcoma |
|
Spleen |
13.0 |
|
| C57BL/6N | Blood vessel hemangiosarcoma |
|
Liver |
8.7 |
|
| C57BL/6N | Blood vessel hemangiosarcoma |
|
Intestine |
34.8 |
|
| CBA/JN | Blood vessel hemangiosarcoma |
|
Spleen |
3.8 |
|
| CBA/JN | Blood vessel hemangiosarcoma |
|
Liver |
3.8 |
|
| CBA/JN | Blood vessel hemangiosarcoma |
|
Intestine |
3.8 |
|
| C3H | Blood vessel hemangiosarcoma |
|
Spleen |
39.3 |
|
| C3H | Blood vessel hemangiosarcoma |
|
Liver |
0 |
|
| C3H | Blood vessel hemangiosarcoma |
|
Intestine |
3.6 |
|
| DBA/2N | Blood vessel hemangiosarcoma |
|
Spleen |
16.7 |
|
| DBA/2N | Blood vessel hemangiosarcoma |
|
Liver |
0 |
|
| DBA/2N | Blood vessel hemangiosarcoma |
|
Intestine |
3.3 |
|
| CD-1 | Blood vessel hemangiosarcoma |
|
Spleen |
25.9 |
|
| CD-1 | Blood vessel hemangiosarcoma |
|
Liver |
3.7 |
|
| CD-1 | Blood vessel hemangiosarcoma |
|
Intestine |
14.8 |
|
| BALB | Intestine adenocarcinoma |
|
Intestine |
6.9 |
|
| C57BL/6N | Intestine adenocarcinoma |
|
Intestine |
17.4 |
|
| CBA/JN | Intestine adenocarcinoma |
|
Intestine |
23.1 |
|
| C3H | Intestine adenocarcinoma |
|
Intestine |
0 |
|
| DBA/2N | Intestine adenocarcinoma |
|
Intestine |
0 |
|
| CD-1 | Intestine adenocarcinoma |
|
Intestine |
0 |
|
| CBA/JN | Intestine adenoma |
|
Intestine |
observed |
|
| BALB | Intestine metaplasia |
|
Intestine |
0 |
|
| BALB | Intestine metaplasia | Intestine |
0 |
||
| C57BL/6N | Intestine metaplasia |
|
Intestine |
0 |
|
| C57BL/6N | Intestine metaplasia | Intestine |
0 |
||
| CBA/JN | Intestine metaplasia |
|
Intestine |
0 |
|
| CBA/JN | Intestine metaplasia | Intestine |
0 |
||
| C3H | Intestine metaplasia |
|
Intestine |
0 |
|
| C3H | Intestine metaplasia | Intestine |
0 |
||
| DBA/2N | Intestine metaplasia |
|
Intestine |
0 |
|
| DBA/2N | Intestine metaplasia | Intestine |
0 |
||
| CD-1 | Intestine metaplasia |
|
Intestine |
0 |
|
| CD-1 | Intestine metaplasia | Intestine |
0 |
||
| CBA/JN | Intestine tumor |
|
Intestine |
observed |
|
| BALB | Leukocyte lymphoma |
|
Spleen |
20.7 |
|
| BALB | Leukocyte lymphoma |
|
Thymus |
6.9 |
|
| C57BL/6N | Leukocyte lymphoma |
|
Spleen |
0 |
|
| C57BL/6N | Leukocyte lymphoma |
|
Thymus |
0 |
|
| CBA/JN | Leukocyte lymphoma |
|
Spleen |
11.5 |
|
| CBA/JN | Leukocyte lymphoma |
|
Thymus |
3.8 |
|
| C3H | Leukocyte lymphoma |
|
Spleen |
3.6 |
|
| C3H | Leukocyte lymphoma |
|
Thymus |
3.6 |
|
| DBA/2N | Leukocyte lymphoma |
|
Spleen |
3.3 |
|
| DBA/2N | Leukocyte lymphoma |
|
Thymus |
3.3 |
|
| CD-1 | Leukocyte lymphoma |
|
Spleen |
0 |
|
| CD-1 | Leukocyte lymphoma |
|
Thymus |
7.4 |
|
| BALB | Liver hepatocellular carcinoma |
|
Liver |
0 |
|
| C57BL/6N | Liver hepatocellular carcinoma |
|
Liver |
0 |
|
| CBA/JN | Liver hepatocellular carcinoma |
|
Liver |
3.8 |
|
| C3H | Liver hepatocellular carcinoma |
|
Liver |
17.9 |
|
| DBA/2N | Liver hepatocellular carcinoma |
|
Liver |
0 |
|
| CD-1 | Liver hepatocellular carcinoma |
|
Liver |
0 |
|
| BALB | Lung adenocarcinoma |
|
Lung |
48.3 |
|
| C57BL/6N | Lung adenocarcinoma |
|
Lung |
4.3 |
|
| CBA/JN | Lung adenocarcinoma |
|
Lung |
46.2 |
|
| C3H | Lung adenocarcinoma |
|
Lung |
0 |
|
| DBA/2N | Lung adenocarcinoma |
|
Lung |
20 |
|
| CD-1 | Lung adenocarcinoma |
|
Lung |
44.4 |
|
| BALB | Stomach - Glandular - Pylorus hyperplasia |
|
Stomach - Glandular - Pylorus |
observed |
|
| C57BL/6N | Stomach - Glandular - Pylorus hyperplasia |
|
Stomach - Glandular - Pylorus |
observed |
|
| CBA/JN | Stomach - Glandular - Pylorus hyperplasia |
|
Stomach - Glandular - Pylorus |
observed |
|
| C3H | Stomach - Glandular - Pylorus hyperplasia |
|
Stomach - Glandular - Pylorus |
observed |
|
| DBA/2N | Stomach - Glandular - Pylorus hyperplasia |
|
Stomach - Glandular - Pylorus |
observed |
|
| CD-1 | Stomach - Glandular - Pylorus hyperplasia |
|
Stomach - Glandular - Pylorus |
observed |
|
| BALB | Stomach - Glandular - Pylorus hyperplasia | Stomach - Glandular - Pylorus |
0 |
||
| C57BL/6N | Stomach - Glandular - Pylorus hyperplasia | Stomach - Glandular - Pylorus |
0 |
||
| CBA/JN | Stomach - Glandular - Pylorus hyperplasia | Stomach - Glandular - Pylorus |
0 |
||
| C3H | Stomach - Glandular - Pylorus hyperplasia | Stomach - Glandular - Pylorus |
0 |
||
| DBA/2N | Stomach - Glandular - Pylorus hyperplasia | Stomach - Glandular - Pylorus |
0 |
||
| CD-1 | Stomach - Glandular - Pylorus hyperplasia | Stomach - Glandular - Pylorus |
0 |
||
| BALB | Stomach - Glandular - Pylorus lesion |
|
Stomach - Glandular - Pylorus |
100 |
|
| C57BL/6N | Stomach - Glandular - Pylorus lesion |
|
Stomach - Glandular - Pylorus |
100 |
|
| CBA/JN | Stomach - Glandular - Pylorus lesion |
|
Stomach - Glandular - Pylorus |
100 |
|
| C3H | Stomach - Glandular - Pylorus lesion |
|
Stomach - Glandular - Pylorus |
100 |
|
| DBA/2N | Stomach - Glandular - Pylorus lesion |
|
Stomach - Glandular - Pylorus |
100 |
|
| CD-1 | Stomach - Glandular - Pylorus lesion |
|
Stomach - Glandular - Pylorus |
100 |
|
| BALB | Stomach - Glandular - Pylorus lesion | Stomach - Glandular - Pylorus |
100 |
||
| C57BL/6N | Stomach - Glandular - Pylorus lesion | Stomach - Glandular - Pylorus |
100 |
||
| CBA/JN | Stomach - Glandular - Pylorus lesion | Stomach - Glandular - Pylorus |
100 |
||
| C3H | Stomach - Glandular - Pylorus lesion | Stomach - Glandular - Pylorus |
100 |
||
| DBA/2N | Stomach - Glandular - Pylorus lesion | Stomach - Glandular - Pylorus |
100 |
||
| CD-1 | Stomach - Glandular - Pylorus lesion | Stomach - Glandular - Pylorus |
100 |
||
| BALB | Stomach - Glandular - Pylorus preneoplastic lesion |
|
Stomach - Glandular - Pylorus |
observed |
|
| C57BL/6N | Stomach - Glandular - Pylorus preneoplastic lesion |
|
Stomach - Glandular - Pylorus |
observed |
|
| CBA/JN | Stomach - Glandular - Pylorus preneoplastic lesion |
|
Stomach - Glandular - Pylorus |
observed |
|
| C3H | Stomach - Glandular - Pylorus preneoplastic lesion |
|
Stomach - Glandular - Pylorus |
observed |
|
| DBA/2N | Stomach - Glandular - Pylorus preneoplastic lesion |
|
Stomach - Glandular - Pylorus |
observed |
|
| CD-1 | Stomach - Glandular - Pylorus preneoplastic lesion |
|
Stomach - Glandular - Pylorus |
observed |
|
| BALB | Stomach - Glandular - Pylorus preneoplastic lesion | Stomach - Glandular - Pylorus |
0 |
||
| C57BL/6N | Stomach - Glandular - Pylorus preneoplastic lesion | Stomach - Glandular - Pylorus |
0 |
||
| CBA/JN | Stomach - Glandular - Pylorus preneoplastic lesion | Stomach - Glandular - Pylorus |
0 |
||
| C3H | Stomach - Glandular - Pylorus preneoplastic lesion | Stomach - Glandular - Pylorus |
0 |
||
| DBA/2N | Stomach - Glandular - Pylorus preneoplastic lesion | Stomach - Glandular - Pylorus |
0 |
||
| CD-1 | Stomach - Glandular - Pylorus preneoplastic lesion | Stomach - Glandular - Pylorus |
0 |
||
| BALB | Stomach - Glandular - Pylorus tumor |
|
Stomach - Glandular - Pylorus |
0 |
|
| C57BL/6N | Stomach - Glandular - Pylorus tumor |
|
Stomach - Glandular - Pylorus |
0 |
|
| CBA/JN | Stomach - Glandular - Pylorus tumor |
|
Stomach - Glandular - Pylorus |
0 |
|
| C3H | Stomach - Glandular - Pylorus tumor |
|
Stomach - Glandular - Pylorus |
0 |
|
| DBA/2N | Stomach - Glandular - Pylorus tumor |
|
Stomach - Glandular - Pylorus |
0 |
|
| CD-1 | Stomach - Glandular - Pylorus tumor |
|
Stomach - Glandular - Pylorus |
0 |
|
| BALB | Stomach - Glandular - Pylorus tumor | Stomach - Glandular - Pylorus |
0 |
||
| C57BL/6N | Stomach - Glandular - Pylorus tumor | Stomach - Glandular - Pylorus |
0 |
||
| CBA/JN | Stomach - Glandular - Pylorus tumor | Stomach - Glandular - Pylorus |
0 |
||
| C3H | Stomach - Glandular - Pylorus tumor | Stomach - Glandular - Pylorus |
0 |
||
| DBA/2N | Stomach - Glandular - Pylorus tumor | Stomach - Glandular - Pylorus |
0 |
||
| CD-1 | Stomach - Glandular - Pylorus tumor | Stomach - Glandular - Pylorus |
0 |
||
| BALB | Stomach - Glandular adenocarcinoma |
|
Stomach - Glandular |
59.3 |
|
| BALB | Stomach - Glandular adenocarcinoma | Stomach - Glandular |
0 |
||
| C57BL/6N | Stomach - Glandular adenocarcinoma |
|
Stomach - Glandular |
31.8 |
|
| C57BL/6N | Stomach - Glandular adenocarcinoma | Stomach - Glandular |
0 |
||
| CBA/JN | Stomach - Glandular adenocarcinoma |
|
Stomach - Glandular |
30.4 |
|
| CBA/JN | Stomach - Glandular adenocarcinoma | Stomach - Glandular |
0 |
||
| C3H | Stomach - Glandular adenocarcinoma |
|
Stomach - Glandular |
26.9 |
|
| C3H | Stomach - Glandular adenocarcinoma | Stomach - Glandular |
0 |
||
| DBA/2N | Stomach - Glandular adenocarcinoma |
|
Stomach - Glandular |
20.7 |
|
| DBA/2N | Stomach - Glandular adenocarcinoma | Stomach - Glandular |
0 |
||
| CD-1 | Stomach - Glandular adenocarcinoma |
|
Stomach - Glandular |
18.5 |
|
| CD-1 | Stomach - Glandular adenocarcinoma | Stomach - Glandular |
0 |
||
| BALB | Stomach - Glandular adenocarcinoma - poorly differentiated |
|
Stomach - Glandular |
3.7 |
|
| C57BL/6N | Stomach - Glandular adenocarcinoma - poorly differentiated |
|
Stomach - Glandular |
0 |
|
| CBA/JN | Stomach - Glandular adenocarcinoma - poorly differentiated |
|
Stomach - Glandular |
4.3 |
|
| C3H | Stomach - Glandular adenocarcinoma - poorly differentiated |
|
Stomach - Glandular |
observed |
|
| DBA/2N | Stomach - Glandular adenocarcinoma - poorly differentiated |
|
Stomach - Glandular |
3.4 |
|
| CD-1 | Stomach - Glandular adenocarcinoma - poorly differentiated |
|
Stomach - Glandular |
observed |
|
| BALB | Stomach - Glandular adenocarcinoma - signet ring cell |
|
Stomach - Glandular |
3.7 |
|
| C57BL/6N | Stomach - Glandular adenocarcinoma - signet ring cell |
|
Stomach - Glandular |
0 |
|
| CBA/JN | Stomach - Glandular adenocarcinoma - signet ring cell |
|
Stomach - Glandular |
0 |
|
| C3H | Stomach - Glandular adenocarcinoma - signet ring cell |
|
Stomach - Glandular |
0 |
|
| DBA/2N | Stomach - Glandular adenocarcinoma - signet ring cell |
|
Stomach - Glandular |
0 |
|
| CD-1 | Stomach - Glandular adenocarcinoma - signet ring cell |
|
Stomach - Glandular |
0 |
|
| BALB | Stomach - Glandular adenocarcinoma - well-differentiated |
|
Stomach - Glandular |
observed |
|
| C57BL/6N | Stomach - Glandular adenocarcinoma - well-differentiated |
|
Stomach - Glandular |
observed |
|
| CBA/JN | Stomach - Glandular adenocarcinoma - well-differentiated |
|
Stomach - Glandular |
observed |
|
| C3H | Stomach - Glandular adenocarcinoma - well-differentiated |
|
Stomach - Glandular |
observed |
|
| DBA/2N | Stomach - Glandular adenocarcinoma - well-differentiated |
|
Stomach - Glandular |
observed |
|
| CD-1 | Stomach - Glandular adenocarcinoma - well-differentiated |
|
Stomach - Glandular |
observed |
|
| BALB | Stomach - Glandular adenoma |
|
Stomach - Glandular |
63.0 |
|
| BALB | Stomach - Glandular adenoma | Stomach - Glandular |
0 |
||
| C57BL/6N | Stomach - Glandular adenoma |
|
Stomach - Glandular |
54.5 |
|
| C57BL/6N | Stomach - Glandular adenoma | Stomach - Glandular |
0 |
||
| CBA/JN | Stomach - Glandular adenoma |
|
Stomach - Glandular |
52.2 |
|
| CBA/JN | Stomach - Glandular adenoma | Stomach - Glandular |
0 |
||
| C3H | Stomach - Glandular adenoma |
|
Stomach - Glandular |
80.8 |
|
| C3H | Stomach - Glandular adenoma | Stomach - Glandular |
0 |
||
| DBA/2N | Stomach - Glandular adenoma |
|
Stomach - Glandular |
51.7 |
|
| DBA/2N | Stomach - Glandular adenoma | Stomach - Glandular |
0 |
||
| CD-1 | Stomach - Glandular adenoma |
|
Stomach - Glandular |
48.1 |
|
| CD-1 | Stomach - Glandular adenoma | Stomach - Glandular |
0 |
||
| BALB | Stomach - Glandular tumor |
|
Stomach - Glandular |
observed |
|
| BALB | Stomach - Glandular tumor | Stomach - Glandular |
0 |
||
| C57BL/6N | Stomach - Glandular tumor |
|
Stomach - Glandular |
observed |
|
| C57BL/6N | Stomach - Glandular tumor | Stomach - Glandular |
0 |
||
| CBA/JN | Stomach - Glandular tumor |
|
Stomach - Glandular |
observed |
|
| CBA/JN | Stomach - Glandular tumor | Stomach - Glandular |
0 |
||
| C3H | Stomach - Glandular tumor |
|
Stomach - Glandular |
observed |
|
| C3H | Stomach - Glandular tumor | Stomach - Glandular |
0 |
||
| DBA/2N | Stomach - Glandular tumor |
|
Stomach - Glandular |
observed |
|
| DBA/2N | Stomach - Glandular tumor | Stomach - Glandular |
0 |
||
| CD-1 | Stomach - Glandular tumor |
|
Stomach - Glandular |
observed |
|
| CD-1 | Stomach - Glandular tumor | Stomach - Glandular |
0 |
||
| DBA/2N | Stomach adenocarcinoma |
|
Stomach |
20.7 |
|
| C3H | Stomach adenocarcinoma |
|
Stomach |
26.1 |
|
| BALB | Stomach adenocarcinoma |
|
Stomach |
57.7 |
|
| CD-1 | Stomach adenocarcinoma |
|
Stomach |
17.9 |
|
| C57BL/6N | Stomach adenocarcinoma |
|
Stomach |
33.3 |
|
| CBA/JN | Stomach adenocarcinoma |
|
Stomach |
29.6 |
|
| BALB | Stomach adenocarcinoma - signet ring cell |
|
Stomach |
observed |
|
| C57BL/6N | Stomach adenocarcinoma - well-differentiated |
|
Stomach |
observed |
|
| DBA/2N | Stomach tumor |
|
Stomach |
observed |
|
| C3H | Stomach tumor |
|
Stomach |
observed |
|
| BALB | Stomach tumor |
|
Stomach |
observed |
|
| CD-1 | Stomach tumor |
|
Stomach |
observed |
|
| C57BL/6N | Stomach tumor |
|
Stomach |
observed |
|
| CBA/JN | Stomach tumor |
|
Stomach |
observed |