Strain SummaryFVB/N-Tg(C3-1-TAg)cJeg
Strain Name |
FVB/N-Tg(C3-1-TAg)cJeg |
Strain Type(s) |
transgenic |
Strain Synonym(s) |
C3(1)/simian virus 40 (SV40) T/t-antigens • C3(1)/SV40 T/t-antigen • C3(1)/SV40 large T antigen • C3(1)/SV40 large T-antigen • C3(1)SV40 large T antigen • C3(1)SV40Tag • C3(1)/SV40 Tag • C3(1)/SV40 TAg • C3(1)/SV40 T/t-antigen • C3(1)/Tag • C3(1)-TAg • C3(1)/TAg • C3(1)/TAG • FVB/N C3(1)SV40Tag • FVB/N C3(1)-TAg • FVB/N C3(1)/TAg • FVB/N C3(1)/TAG • FVB/N-TgN(C3-1-TAg)3Jeg • FVB/N-TgN(C3(1)/TAg)3Jeg • FVB/N-TgN(C3-1-TAg)cJeg • C3(1)/TAg+/- • line C • PRP-3 • TAG FVB-N |
Description |
Hemizygous mice. The founder of this line carried 6 copies of the transgene. "Line C" was the line maintained by the original investigators for further experiments. |
Strain Genetics |
Tg(C3-1-TAg)cJeg |
| Frequency | ||||||||
|---|---|---|---|---|---|---|---|---|
| Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
| Mammary gland adenocarcinoma | Mammary gland |
observed - 100 |
References: Green JE, Cancer Res 2001 Oct 15;61(20):7449-55 ⋅ Liu ML, Oncogene 1998 Nov 5;17(18):2403-11 ⋅ Maroulakou IG, Mol Carcinog 1997 Oct;20(2):168-74 ⋅ Maroulakou IG, Proc Natl Acad Sci U S A 1994 Nov 8;91(23):11236-40 ⋅ Mikaelian I, Personal Communication 2004;(): ⋅ Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 ⋅ Shibata MA, EMBO J 1999 May 17;18(10):2692-701 Sites of Metastasis: not Lung , Lung 18 pathology image(s) |
|||||
| Mammary gland adenocarcinoma | Mammary gland | 2-difluoromethylornithine (DFMO) |
82 - 92 |
References: Green JE, Cancer Res 2001 Oct 15;61(20):7449-55 |
||||
| Mammary gland adenocarcinoma | Mammary gland | dehydroepiandrosterone (DHEA) |
68 - 71 |
References: Green JE, Cancer Res 2001 Oct 15;61(20):7449-55 |
||||
| Mammary gland adenocarcinoma | Mammary gland | N-(4-hydroxyphenyl)retinamide (4HPR) |
very high |
References: Green JE, Cancer Res 2001 Oct 15;61(20):7449-55 |
||||
| Mammary gland adenocarcinoma | Mammary gland | lovastatin |
observed |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 Sites of Metastasis: not Lung |
||||
| Mammary gland adenocarcinoma - mixed | Mammary gland |
observed |
References: Mikaelian I, Personal Communication 2004;(): 6 pathology image(s) |
|||||
| Mammary gland adenocarcinoma - solid | Mammary gland |
observed |
References: Mikaelian I, Personal Communication 2004;(): 11 pathology image(s) |
|||||
| Mammary gland carcinoma - mixed | Mammary gland |
observed |
References: Mikaelian I, Personal Communication 2004;(): 3 pathology image(s) |
|||||
| Mammary gland carcinoma in situ - ductal | Mammary gland |
observed |
References: Mikaelian I, Personal Communication 2004;(): 9 pathology image(s) |
|||||
| Mammary gland dysplasia | Mammary gland |
observed |
References: Maroulakou IG, Mol Carcinog 1997 Oct;20(2):168-74 |
|||||
| Mammary gland hyperplasia | Mammary gland |
observed |
References: Liu ML, Oncogene 1998 Nov 5;17(18):2403-11 |
|||||
| Mammary gland hyperplasia - atypical | Mammary gland |
observed - 100 |
References: Maroulakou IG, Mol Carcinog 1997 Oct;20(2):168-74 ⋅ Mikaelian I, Personal Communication 2004;(): ⋅ Shibata MA, EMBO J 1999 May 17;18(10):2692-701 6 pathology image(s) |
|||||
| Mammary gland hyperplasia - atypical - ductal | Mammary gland |
observed |
References: Mikaelian I, Personal Communication 2004;(): 2 pathology image(s) |
|||||
| Mammary gland hyperplasia - nodular | Mammary gland |
observed - 100 |
References: Liu ML, Oncogene 1998 Nov 5;17(18):2403-11 ⋅ Shibata MA, EMBO J 1999 May 17;18(10):2692-701 |
|||||
| Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland | dehydroepiandrosterone (DHEA) |
observed |
References: Green JE, Cancer Res 2001 Oct 15;61(20):7449-55 |
||||
| Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland | 2-difluoromethylornithine (DFMO) |
observed |
References: Green JE, Cancer Res 2001 Oct 15;61(20):7449-55 |
||||
| Mammary gland mammary intraepithelial neoplasia (MIN) | Mammary gland |
observed |
References: Green JE, Cancer Res 2001 Oct 15;61(20):7449-55 |
|||||
| Mammary gland mammary intraepithelial neoplasia (MIN) - high grade | Mammary gland | lovastatin |
observed |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
||||
| Mammary gland mammary intraepithelial neoplasia (MIN) - high grade | Mammary gland |
very high |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
|||||
| Mammary gland mammary intraepithelial neoplasia (MIN) - low grade | Mammary gland |
100 |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
|||||
| Mammary gland mammary intraepithelial neoplasia (MIN) - low grade | Mammary gland | lovastatin |
observed |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
||||
| Mammary gland tumor - basal | Mammary gland |
observed |
References: Zhu M, Genome Biol 2011;12(8):R77 |
|||||
| Prostate gland - Anterior lobe lesion | Prostate gland - Anterior lobe |
0 |
References: Shibata MA, Cancer Res 1996 Nov 1;56(21):4894-903 |
|||||
| Prostate gland - Dorsolateral lobe adenocarcinoma | Prostate gland - Dorsolateral lobe |
0 - 24 |
References: Shibata MA, Cancer Res 1996 Nov 1;56(21):4894-903 |
|||||
| Prostate gland - Dorsolateral lobe carcinoma | Prostate gland - Dorsolateral lobe |
10 |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
|||||
| Prostate gland - Dorsolateral lobe carcinoma | Prostate gland - Dorsolateral lobe | lovastatin |
0 |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
||||
| Prostate gland - Dorsolateral lobe prostatic intraepithelial neoplasia (PIN) | Prostate gland - Dorsolateral lobe |
0 - 100 |
References: Shibata MA, Cancer Res 1996 Nov 1;56(21):4894-903 |
|||||
| Prostate gland - Dorsolateral lobe prostatic intraepithelial neoplasia - high grade (HGPIN) | Prostate gland - Dorsolateral lobe | lovastatin |
64 |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
||||
| Prostate gland - Dorsolateral lobe prostatic intraepithelial neoplasia - high grade (HGPIN) | Prostate gland - Dorsolateral lobe |
50 |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
|||||
| Prostate gland - Dorsolateral lobe prostatic intraepithelial neoplasia - low grade (LGPIN) | Prostate gland - Dorsolateral lobe | lovastatin |
100 |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
||||
| Prostate gland - Dorsolateral lobe prostatic intraepithelial neoplasia - low grade (LGPIN) | Prostate gland - Dorsolateral lobe |
100 |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
|||||
| Prostate gland - Ventral lobe adenocarcinoma | Prostate gland - Ventral lobe |
0 - 39 |
References: Shibata MA, Cancer Res 1996 Nov 1;56(21):4894-903 |
|||||
| Prostate gland - Ventral lobe carcinoma | Prostate gland - Ventral lobe |
30 |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
|||||
| Prostate gland - Ventral lobe carcinoma | Prostate gland - Ventral lobe | lovastatin |
24 |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
||||
| Prostate gland - Ventral lobe prostatic intraepithelial neoplasia (PIN) | Prostate gland - Ventral lobe |
0 - 100 |
References: Shibata MA, Cancer Res 1996 Nov 1;56(21):4894-903 |
|||||
| Prostate gland - Ventral lobe prostatic intraepithelial neoplasia - high grade (HGPIN) | Prostate gland - Ventral lobe | lovastatin |
76 |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
||||
| Prostate gland - Ventral lobe prostatic intraepithelial neoplasia - high grade (HGPIN) | Prostate gland - Ventral lobe |
60 |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
|||||
| Prostate gland - Ventral lobe prostatic intraepithelial neoplasia - low grade (LGPIN) | Prostate gland - Ventral lobe | lovastatin |
100 |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
||||
| Prostate gland - Ventral lobe prostatic intraepithelial neoplasia - low grade (LGPIN) | Prostate gland - Ventral lobe |
100 |
References: Shibata MA, Carcinogenesis 2003 Mar;24(3):453-9 |
|||||
| Prostate gland adenocarcinoma | Prostate gland |
observed |
References: Maroulakou IG, Proc Natl Acad Sci U S A 1994 Nov 8;91(23):11236-40 ⋅ Shibata MA, Cancer Res 1996 Nov 1;56(21):4894-903 |
|||||
| Prostate gland carcinoma | Prostate gland |
observed |
References: Maroulakou IG, Mol Carcinog 1997 Oct;20(2):168-74 |
|||||
| Prostate gland dysplasia | Prostate gland |
observed |
References: Maroulakou IG, Mol Carcinog 1997 Oct;20(2):168-74 |
|||||
| Prostate gland hyperplasia | Prostate gland |
observed |
References: Maroulakou IG, Proc Natl Acad Sci U S A 1994 Nov 8;91(23):11236-40 |
|||||
| Prostate gland prostatic intraepithelial neoplasia (PIN) | Prostate gland |
very high |
References: Green JE, Cancer Res 2001 Oct 15;61(20):7449-55 ⋅ Shibata MA, Cancer Res 1996 Nov 1;56(21):4894-903 |
|||||
| Prostate gland prostatic intraepithelial neoplasia (PIN) | Prostate gland | 2-difluoromethylornithine (DFMO) |
very high |
References: Green JE, Cancer Res 2001 Oct 15;61(20):7449-55 |
||||
| Prostate gland prostatic intraepithelial neoplasia (PIN) | Prostate gland | tocopherol acetate |
very high |
References: Green JE, Cancer Res 2001 Oct 15;61(20):7449-55 |
||||
| Prostate gland prostatic intraepithelial neoplasia (PIN) | Prostate gland | selenomethionine |
very high |
References: Green JE, Cancer Res 2001 Oct 15;61(20):7449-55 |
||||
| Prostate gland prostatic intraepithelial neoplasia (PIN) | Prostate gland | 9-cis-retinoic acid |
very high |
References: Green JE, Cancer Res 2001 Oct 15;61(20):7449-55 |
||||
| Seminal vesicle lesion | Seminal vesicle |
0 |
References: Shibata MA, Cancer Res 1996 Nov 1;56(21):4894-903 |
|||||