Strain SummaryFVB/NTac-Tg(Hba-x-v-Ha-ras)TG.ACLed

Strain Name

 FVB/NTac-Tg(Hba-x-v-Ha-ras)TG.ACLed

Strain Type(s)

 transgenic

Strain Synonym(s)

 FVB/NfBR-[Tg]v Ha ras  •  FVB/NTac-Tg(v-Ha-ras)TG.ACLed  •  FVB/N-Tg(Hba-x-v-Ha-ras)TG.ACLed  •  FVB/N-TgN(TG.AC)#Led  •  FVB/N-Tg(TG.AC)#Led  •  hemizygous Tg.AC  •  Tg.AC  •  TG.AC  •  Tg.AC hemizygous  •  v-Ha-ras

Description

 Hemizygous mice. The transgene integrated on chromosome 11.

Strain Genetics

 Tg(Hba-x-v-Ha-ras)TG.ACLed

Models

88 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Connective tissue - Fibroblast fibroma - ossifying Tooth

observed

References: Pathbase web site, University of Cambridge, MGI Direct Data Submission 2009;():

1 pathology image(s)
Connective tissue - Ligament tumor Bone - Jaw

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Erythrocyte leukemia - erythroleukemia Erythrocyte

2.2 - 6.7

0.6 - 8.3

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80   ⋅   Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Erythrocyte leukemia - erythroleukemia Liver

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Forestomach hyperplasia - squamous Forestomach dimethyl vinyl chloride (DMVC)

86.7

93.3

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Forestomach hyperplasia - squamous Forestomach

86.7

100

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Forestomach hyperplasia - squamous Forestomach sulfamethoxazole (SMX)

93.3 - 100

86.7 - 100

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Forestomach papilloma Forestomach

10.3 - 25.4

7.4 - 21.7

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80   ⋅   Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Forestomach squamous cell carcinoma Forestomach

0

0

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Forestomach squamous cell papilloma Forestomach melphalan (L-phenylalanine mustard) (L-sarcolysin)

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Forestomach tumor Forestomach

0 - 42.9

0 - 40

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Forestomach tumor Forestomach sulfisoxazole

6.7 - 20

0 - 14.3

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Forestomach tumor Forestomach dimethyl vinyl chloride (DMVC)

66.7

53.3 - 86.7

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Forestomach tumor Forestomach sulfamethoxazole (SMX)

0 - 26.7

6.7 - 20

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Forestomach tumor Forestomach phenobarbital (PB)

0

0

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Forestomach tumor Forestomach phenacetin

27.3 - 40

0 - 71.4

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Intestine - Small Intestine carcinoma Intestine - Small Intestine

0.5

0

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Uterus

0.5

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Subcutis

0.5

0

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Leukocyte - Myelocyte (Granulocyte) dysplasia Leukocyte - Myelocyte (Granulocyte) rotenone

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Leukocyte lymphoma Leukocyte

0 - 1.1

0 - 1.7

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80   ⋅   Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Leukocyte lymphoma Leukocyte Cyclosporin A

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Sites of Metastasis: Kidney , Liver , Lung
Lung adenoma Lung

1.6

4.3

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Lung adenoma Lung melphalan (L-phenylalanine mustard) (L-sarcolysin)

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Lung carcinoma Lung

0.5

0

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Lung carcinoma Lung melphalan (L-phenylalanine mustard) (L-sarcolysin)

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Lung hyperplasia Lung melphalan (L-phenylalanine mustard) (L-sarcolysin)

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Lung tumor Lung

1.7

5.0

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Mesodermal cell/mesoblast sarcoma - spindle cell Skin

0

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Mesodermal cell/mesoblast sarcoma - spindle cell Skin phorbol 12-myristate 13-acetate (phorbol ester) (PMA)

observed

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Sites of Metastasis: Lymph node
Mesodermal cell/mesoblast sarcoma - spindle cell Skin retinoic acid (RA)

0

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Mesodermal cell/mesoblast sarcoma - spindle cell Skin phorbol 12-myristate 13-acetate (phorbol ester) (PMA)   ⋅   retinoic acid (RA)

observed

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Sites of Metastasis: Lymph node
Mesodermal cell/mesoblast sarcoma - spindle cell Skin wounding

observed

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Sites of Metastasis: Lymph node
Nose adenoma Bone - Jaw - Maxilla sulfisoxazole

observed

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Ovary - Germ cell teratoma Ovary - Germ cell

1.6

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Salivary gland - Salivary duct - Submandibular squamous cell carcinoma Salivary gland - Salivary duct - Submandibular

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Salivary gland - Salivary duct squamous cell carcinoma Salivary gland - Salivary duct

2.2

1.2

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Salivary gland carcinoma Salivary gland

0

1.7

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Skin - Dorsal region papilloma Skin - Dorsal region 12-O-tetradecanoylphorbol-13-acetate (TPA)

100

References: Ridd K, Carcinogenesis 2006 Aug;27(8):1556-66

Skin - Dorsal region papilloma Skin - Dorsal region

0

References: Ridd K, Carcinogenesis 2006 Aug;27(8):1556-66

Skin - Dorsal region tumor Skin - Dorsal region 12-O-tetradecanoylphorbol-13-acetate (TPA)

40 - 100

33.3 - 100

96.7

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Skin - Dorsal region tumor Skin - Dorsal region

0 - 21.4

0 - 6.7

7.1

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Skin - Dorsal region tumor Skin - Dorsal region sulfisoxazole

0 - 6.7

0 - 20

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Skin - Dorsal region tumor Skin - Dorsal region sulfamethoxazole (SMX)

4.2 - 10.7

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Skin - Dorsal region tumor Skin - Dorsal region phenobarbital (PB)

0

0

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Skin carcinoma - spindle cell Skin (unspecified chemical)

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Skin hyperplasia Skin phorbol 12-myristate 13-acetate (phorbol ester) (PMA)

observed

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Skin keratoacanthoma Skin phorbol 12-myristate 13-acetate (phorbol ester) (PMA)

observed

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Skin keratoacanthoma Skin (unspecified chemical)

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Skin papilloma Skin wounding

observed

observed - 100

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Skin papilloma Skin

0 - 5.6

0

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82   ⋅   Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54

Skin papilloma Skin phorbol 12-myristate 13-acetate (phorbol ester) (PMA)

97

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Skin papilloma Skin retinoic acid (RA)

0

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Skin papilloma Skin phorbol 12-myristate 13-acetate (phorbol ester) (PMA)   ⋅   retinoic acid (RA)

25 - 42

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Skin papilloma Skin - Anogenital region

20 - 22

11 - 14

References: Holden HE, J Appl Toxicol 1998 Jan-Feb;18(1):19-24

Skin papilloma Skin - Anogenital region acetone

0 - 20

25 - 44

References: Holden HE, J Appl Toxicol 1998 Jan-Feb;18(1):19-24

Skin papilloma Skin - Anogenital region benzene

22 - 43

12.5 - 30

References: Holden HE, J Appl Toxicol 1998 Jan-Feb;18(1):19-24

Skin papilloma Skin - Anogenital region phorbol 12-myristate 13-acetate (phorbol ester) (PMA)

0 - 25

12.5 - 37.5

References: Holden HE, J Appl Toxicol 1998 Jan-Feb;18(1):19-24

Skin papilloma Skin - Dorsal region

0

0 - 10

References: Holden HE, J Appl Toxicol 1998 Jan-Feb;18(1):19-24

Skin papilloma Skin - Dorsal region acetone

0

0 - 10

References: Holden HE, J Appl Toxicol 1998 Jan-Feb;18(1):19-24

Skin papilloma Skin - Dorsal region benzene

10

0 - 30

References: Holden HE, J Appl Toxicol 1998 Jan-Feb;18(1):19-24

Skin papilloma Skin - Dorsal region phorbol 12-myristate 13-acetate (phorbol ester) (PMA)

40 - 70

70 - 90

References: Holden HE, J Appl Toxicol 1998 Jan-Feb;18(1):19-24

Skin papilloma Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)

observed - 100

93

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80   ⋅   Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54

Skin papilloma Skin benzene

92.9 - 100

References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54

Skin papilloma Skin lauric acid diethanolamine (LDA)

20 - 86.7

References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54

Skin squamous cell carcinoma Skin

0.5

0

0

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82   ⋅   Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Skin squamous cell carcinoma Skin phorbol 12-myristate 13-acetate (phorbol ester) (PMA)

observed

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Sites of Metastasis: Lymph node
Skin squamous cell carcinoma Skin retinoic acid (RA)

0

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Skin squamous cell carcinoma Skin phorbol 12-myristate 13-acetate (phorbol ester) (PMA)   ⋅   retinoic acid (RA)

observed

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Sites of Metastasis: Lymph node
Skin squamous cell carcinoma Skin wounding

observed

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Sites of Metastasis: Lymph node
Skin squamous cell carcinoma Skin (unspecified chemical)

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Skin squamous cell papilloma Skin

3.8

3.7

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Skin squamous cell papilloma Skin (unspecified chemical)

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Skin tumor Skin

1.7

0

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Spleen hyperplasia Spleen

observed

References: Leder A, Proc Natl Acad Sci U S A 1990 Dec;87(23):9178-82

Tooth ameloblastoma Bone - Jaw - Mandible

observed

References: Pathbase web site, University of Cambridge, MGI Direct Data Submission 2009;():

3 pathology image(s)
Tooth ameloblastoma Bone - Jaw

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Tooth odontoma Bone - Jaw

0 - 10

0 - 20

observed

References: Holden HE, J Appl Toxicol 1998 Jan-Feb;18(1):19-24   ⋅   Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11   ⋅   Pathbase web site, University of Cambridge, MGI Direct Data Submission 2009;():   ⋅   Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54

1 pathology image(s)
Tooth odontoma Bone - Jaw acetone

0 - 20

10

References: Holden HE, J Appl Toxicol 1998 Jan-Feb;18(1):19-24

Tooth odontoma Bone - Jaw benzene

observed - 30

0

References: Holden HE, J Appl Toxicol 1998 Jan-Feb;18(1):19-24   ⋅   Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54

Tooth odontoma Bone - Jaw phorbol 12-myristate 13-acetate (phorbol ester) (PMA)

0 - 10

0

References: Holden HE, J Appl Toxicol 1998 Jan-Feb;18(1):19-24

Tooth odontoma Bone - Jaw 12-O-tetradecanoylphorbol-13-acetate (TPA)

observed

References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54

Tooth odontoma Bone - Jaw lauric acid diethanolamine (LDA)

observed

References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54

Tooth tumor Bone - Jaw

17.3

13.0

observed

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

Tooth tumor Tooth

18.3

26.7

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

Uterus - Endometrium adenoma Uterus - Endometrium

0.5

References: Mahler JF, Toxicol Pathol 1998 Jul-Aug;26(4):501-11

(Unspecified organ) tumor (Unspecified organ)

3.3

1.7

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80

(Unspecified organ) tumor (Unspecified organ) phenobarbital (PB)

0

0

References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80