Strain SummaryB6;129S1-Cdkn2b^tm1Bbd

Strain Name	B6;129S1-Cdkn2b^tm1Bbd
Strain Type(s)	targeted mutation (knockout)
Strain Synonym(s)	P15^INK4b (-/-) • KO-p15 • P15INK4b (-/-)
Description	Mice homozygous for a targeted mutation of Cdkn2b (p15INK4b). The genetic background was a mix of C57BL/6 and 129S1/Sv-p⁺ Tyr⁺ Kitl⁺.
Strain Genetics	List all models in MMHCdb carrying the Cdkn2b^tm1Bbd allele Cdkn2b^tm1Bbd / Cdkn2b^tm1Bbd
	Cdkn2c⁺ / Cdkn2c⁺

Models
12 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Connective tissue - Fibroblast fibrosarcoma	Skin					0.7	References: Latres E, EMBO J 2000 Jul 3;19(13):3496-506
Connective tissue - Fibroblast fibrosarcoma	Tail					0	References: Jimenez M, Cancer Res 2004 Sep 1;64(17):6041-9
Connective tissue - Fibroblast fibrosarcoma	Limb - Forelimb					0	References: Jimenez M, Cancer Res 2004 Sep 1;64(17):6041-9
Connective tissue - Fibroblast fibrosarcoma	Limb - Hindlimb					0	References: Jimenez M, Cancer Res 2004 Sep 1;64(17):6041-9
Leukocyte - Lymphocyte - B-lymphocyte hyperplasia	Lymph node					13	References: Latres E, EMBO J 2000 Jul 3;19(13):3496-506
Leukocyte - Lymphocyte - B-lymphocyte hyperplasia	Spleen					observed	References: Latres E, EMBO J 2000 Jul 3;19(13):3496-506
Leukocyte - Lymphocyte lymphoma	Leukocyte - Lymphocyte					0.7	References: Latres E, EMBO J 2000 Jul 3;19(13):3496-506
Leukocyte lymphoma	Spleen					0	References: Jimenez M, Cancer Res 2004 Sep 1;64(17):6041-9
Lung adenocarcinoma	Lung					0.7	References: Latres E, EMBO J 2000 Jul 3;19(13):3496-506
Pancreas adenocarcinoma	Pancreas					0.7	References: Latres E, EMBO J 2000 Jul 3;19(13):3496-506
Skin papilloma	Skin	ultraviolet-B radiation (UVB) ⋅ dimethylbenzanthracene (DMBA)				4.5	References: Latres E, EMBO J 2000 Jul 3;19(13):3496-506
(Unspecified organ) angiosarcoma	(Unspecified organ)					5.2	References: Latres E, EMBO J 2000 Jul 3;19(13):3496-506

Models