Reference SummaryJimenez M, Cancer Res 2004 Sep 1;64(17):6041-9
Title |
The Rgr oncogene induces tumorigenesis in transgenic mice. |
Authors |
Jimenez M; Perez de Castro I; Benet M; Garcia JF; Inghirami G; Pellicer A |
Journal |
Cancer Res |
Volume |
64 |
Issue |
17 |
Year |
2004 |
Pages |
6041-9 |
Abstract |
To study the oncogenic potential of Rgr in vivo, we have generated several transgenic Rgr mouse lines, which express the oncogene under the control of different promoters. These studies revealed that Rgr expression leads to the generation of various pathological alterations, including fibrosarcomas, when its transgenic expression is restricted to nonlymphoid tissues. Moreover, the overall incidence and latency of fibrosarcomas were substantially increased and shortened, respectively, in a p15INK4b-defective background. More importantly, we also have demonstrated that Rgr expression in thymocytes of transgenic mice induces severe alterations in the development of the thymocytes, which eventually lead to a high incidence of thymic lymphomas. This study demonstrates that oncogenic Rgr can induce expression of p15INK4b and, more importantly, that both Rgr and p15INK4b cooperate in the malignant phenotype in vivo. These findings provide new insights into the tumorigenic role of Rgr as a potent oncogene and show that p15INK4b can act as a tumor suppressor gene. |
Links |
J:92408 – MGI References 15342385 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| FVB/N-Tg(MSV-Rgl2)#Pel | Connective tissue - Fibroblast fibrosarcoma | Limb - Forelimb |
10 |
||
| FVB/N-Tg(MSV-Rgl2)#Pel | Connective tissue - Fibroblast fibrosarcoma | Limb - Hindlimb |
10 |
||
| STOCK Cdkn2btm1Bpd Tg(MSV-Rgl2)#Pel | Connective tissue - Fibroblast fibrosarcoma | Limb - Hindlimb |
100 |
||
| STOCK Cdkn2btm1Bpd Tg(MSV-Rgl2)#Pel | Connective tissue - Fibroblast fibrosarcoma | Limb - Forelimb |
100 |
||
| STOCK Cdkn2btm1Bpd Tg(MSV-Rgl2)#Pel | Connective tissue - Fibroblast fibrosarcoma | Ear |
100 |
||
| STOCK Cdkn2btm1Bpd Tg(MSV-Rgl2)#Pel | Connective tissue - Fibroblast fibrosarcoma | Tail |
100 |
||
| FVB/N-Tg(MSV-Rgl2)#Pel | Connective tissue - Fibroblast fibrosarcoma | Tail |
10 |
||
| B6;129S1-Cdkn2btm1Bbd | Connective tissue - Fibroblast fibrosarcoma | Tail |
0 |
||
| B6;129S1-Cdkn2btm1Bbd | Connective tissue - Fibroblast fibrosarcoma | Limb - Forelimb |
0 |
||
| B6;129S1-Cdkn2btm1Bbd | Connective tissue - Fibroblast fibrosarcoma | Limb - Hindlimb |
0 |
||
| FVB/N-Tg(MSV-Rgl2)#Pel | Eye - Harderian gland adenoma | Eye - Harderian gland |
100 |
||
| STOCK Cdkn2btm1Bpd Tg(MSV-Rgl2)#Pel | Leukocyte lymphoma | Spleen |
50 |
||
| FVB/N-Tg(Cd4-Rgl2)19Pel | Leukocyte lymphoma | Thymus |
83 |
||
| FVB/N-Tg(Cd4-Rgl2)37Pel | Leukocyte lymphoma | Thymus |
38 |
||
| FVB/N-Tg(Cd4-Rgl2)42Pel | Leukocyte lymphoma | Thymus |
68 |
||
| FVB/N-Tg(MSV-Rgl2)#Pel | Leukocyte lymphoma | Spleen |
0 |
||
| B6;129S1-Cdkn2btm1Bbd | Leukocyte lymphoma | Spleen |
0 |
||
| STOCK Cdkn2btm1Bpd Tg(MSV-Rgl2)#Pel | Lymphoid tissue hyperplasia | Spleen |
100 |
||
| FVB/N-Tg(Cd4-Rgl2)19Pel | (Unspecified organ) tumor | (Unspecified organ) |
93.33 |
||
| FVB/N-Tg(Cd4-Rgl2)37Pel | (Unspecified organ) tumor | (Unspecified organ) |
62.96 |
||
| FVB/N-Tg(Cd4-Rgl2)42Pel | (Unspecified organ) tumor | (Unspecified organ) |
86.96 |
||
| FVB/N | (Unspecified organ) tumor | (Unspecified organ) |
0 |