Model DetailsLeukocyte - Myelocyte (Granulocyte) hyperplasia(Spleen)

Model Name

 Leukocyte - Myelocyte (Granulocyte) hyperplasia  (Spleen)

Strain
B6;129-Krastm4.1Bbd

Tumor Inducing Agent(s)

 Chemical/Drug : PD0325901 (MEK inhibitor)

Tumor Synonyms

 myeloproliferative disease (MPD)  •  splenomegaly

Strain Synonyms

 B6/129-KRasV14I  •  K-RasV14I  •  K-RasV14I/V14I  •  AVB line  •  C57BL/6J.OlaHsd/129S2/SvPasCrl-KRasV14I
Organ Affected Sex Frequency Age Of Detection Additional Information Expand all Collapse all Reference
Spleen Male

100%

(13 of 13 mice) 		4 months
  • Treatment Notes
  • Notes

    Reproductive Status: reproductive status not specified

 Hernandez-Porras I, Proc Natl Acad Sci U S A 2014 Nov 18;111(46):16395-400