Model DetailsThyroid gland - Medulla - C cell hyperplasia

Model Name

 Thyroid gland - Medulla - C cell hyperplasia

Strain
[not specified]-Calcatm1.1(cre/ERT2)Ptch/+ Rb1tm2Brn Trp53tm1Brn

Tumor Inducing Agent(s)

 Genetic Modification : tamoxifen (for inducing expression from mutant alleles)

Tumor Synonyms

 parafollicular C cell hyperplasia  •  proliferation of parafollcular C cells

Strain Synonyms

 double knock-out  •  p53-/-; Rb-/-  •  DKO  •  p53/Rb DKO  •  CGRPCreER/+; p53f/f; Rbf/f  •  p53/Rb-deficient
Organ Affected Sex Frequency Age Of Detection Additional Information Expand all Collapse all Reference
Thyroid gland - Medulla - C cell Mixed Population

100%

(41 of 41 mice) 		 
  • Treatment Notes
  • Notes

    Reproductive Status: reproductive status not specified

  • Age of Onset

    ~2-4 months

  • Pathology Reports
Song H, J Biol Chem 2017 Mar 3;292(9):3888-3899