

PDX Model DetailsTM00916

Request information on the availability of this model.

PDX Model Summary
Model Details	Model ID (Previous ID) TM00916 (OM1058F) Initial Diagnosis Ovary serous adenocarcinoma Final Diagnosis Ovary serous adenocarcinoma Stage/Grade AJCC IV / Grade:3 Primary Site Ovary Sample Site Omentum Tumor Type Metastatic
Related Models	PDX models TM00916, TM00913 and TM00914 originated from the same patient.
Patient	Sex Female Age (at time of tissue collection) 68 Race/Ethnicity White / Not Hispanic or Latino Treatment Naïve? Yes Current Smoker/Former Smoker Unknown / Unknown
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site no data

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: RNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample OM1058F141P059P1 from passage P1 has a TMB score of 4.04 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:OM1058F141P059P1 from passage P1 Score:MSI-S
Gene Fusion	Fusion Genes Sample OM1058F141P0 has fusion genes NUDT3--ILRUN, PDXDC1--NPIPB14P, DNM1L--FGD4, PKD1--NPIPP1, SMAD3--LINC02853, VAMP8--VAMP5, LINC02831--PPP3R1, USP39--NFE2, ITPR2--TM7SF3, SCAI--LINC01411, TXNDC11--FBLN2, FGFR3--NSD2, LAMC2--AL354953.1, TVP23C--CDRT4, CAPZB--RNF186, AC008667.1--UBE2D2, ARID5B--CABCOCO1, ADGRL2--ADGRL3, AC097500.1--FSIP2-AS1, ARHGEF5--OR2A7, PCDHGB1--PCDHGC4, SUPV3L1--KIFBP, MDN1--BACH2, SMARCC1--GCDH, ADIPOR2--ERC1, ARPC4--TTLL3, STX16--NPEPL1, ERI3--EIF2B3, AC138866.1--AP000346.2, NARF--LIN52, SLC6A6--GSPT1, LIMS1--AC140479.3, SMURF2P1--LRRC37B, PDCL--DENND1A, DSN1--CDK12, POLR2J2--AC004951.2, ZBTB17--WDFY3-AS1, CAPZB--TMCO4, ZNF880--AC010332.1, CTBS--GNG5, LINC00630--Z68871.1, ZNF738--AC010615.1, MRI1--ATP9A, PDZD8--EMX2OS, RBPMS2--SMYD3, TMEM182--USP40, BOLA2B--SMG1, MYEOV--CROCC, RBM14--RBM4, HK1--KIFBP, AL078587.2--AL390198.2, RXRA--SAXO1, ABCC1--BMERB1, UIMC1--LMAN2, SLC6A6--ZC3H7A, PABPC1L--OSCP1, PRRG2--AP2A1, RDH13--FIZ1, PCDHA4--PCDHAC1, MECOM--LRRC31, PARP6--HIGD2B, SLC6A6--BCAR4, PELI2--TRAV12-1, WDFY3-AS1--ARHGEF19, ATXN10--ANKS1A, GPCPD1--MAP4, XPO5--DSN1, TTC39C--TMEM184B Sample OM1058F141P059P1 has fusion genes AC078883.1--ITGA6-AS1, PDXDC1--NPIPB14P, DNM1L--FGD4, PKD1--NPIPP1, SYS1--DBNDD2, SMAD3--LINC02853, VAMP8--VAMP5, LINC02831--PPP3R1, BOLA2B--SMG1P2, SLC2A11--MIF, USP39--NFE2, ITPR2--TM7SF3, SCAI--LINC01411, TXNDC11--FBLN2, LAMC2--AL354953.1, EFCAB14--ATPAF1, TVP23C--CDRT4, CAPZB--RNF186, MACC1--AC005062.1, NFYA--ADCY10P1, ARID5B--CABCOCO1, RNF123--IHO1, ARHGEF5--OR2A7, ZNF662--KRBOX1, AL133410.1--NPR2, SUPV3L1--KIFBP, MDN1--BACH2, SMARCC1--GCDH, ADIPOR2--ERC1, AC008443.2--AC008443.5, UPK3B--PMS2P9, ARPC4--TTLL3, STX16--NPEPL1, ERI3--EIF2B3, NARF--LIN52, SLC6A6--GSPT1, AC138409.2--AP000346.2, LIMS1--AC140479.3, SMURF2P1--LRRC37B, PDCL--DENND1A, DSN1--CDK12, PLPP3--AC119674.2, ZBTB17--WDFY3-AS1, NACC2--UNC13B, POLR2J3--AC004951.2, ANKHD1--EIF4EBP3, ASLP1--AP000346.2, ZNF880--AC010332.1, CTBS--GNG5, MRI1--ATP9A, PDZD8--EMX2OS, RBPMS2--SMYD3, TMEM182--USP40, MYEOV--CROCC, HK1--KIFBP, AL078587.2--AL390198.2, RXRA--SAXO1, SLC25A13--RLF, ABCC1--BMERB1, UIMC1--LMAN2, SLC6A6--ZC3H7A, PABPC1L--OSCP1, PRRG2--AP2A1, RBM14--RBM4B, AC080129.2--IRAG2, RDH13--FIZ1, PCDHA4--PCDHAC1, GATAD1--AC007566.1, RNASEH1--AC108488.1, PARP6--HIGD2B, SLC6A6--BCAR4, KLHL5--AC079921.2, AC025178.1--GOLPH3, WDFY3-AS1--ARHGEF19, ATXN10--ANKS1A, GPCPD1--MAP4, XPO5--DSN1, TTC39C--TMEM184B

Model Characterization

Histology

Summary:
P0, P1, P2 pathology consistent with serous carcinoma of ovary.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F141 for PDX model TM00916 stained for H&E.	P0 tumor F141 for PDX model TM00916 stained for AE1AE3. Staining was positive
P0 tumor F141 for PDX model TM00916 stained for CD45. Staining was negative.	P1 tumor F141 for PDX model TM00916 stained for H&E.
P2 tumor F142 ID007 for PDX model TM00916 stained for H&E.

Dosing Studies

no data

Circos Plots

no data