Reference SummaryLiu J, Nat Commun 2019 May 14;10(1):2148

Title

 JNK(1/2) represses Lkb(1)-deficiency-induced lung squamous cell carcinoma progression.

Authors

 Liu J; Wang T; Creighton CJ; Wu SP; Ray M; Janardhan KS; Willson CJ; Cho SN; Castro PD; Ittmann MM; Li JL; Davis RJ; DeMayo FJ

Journal

 Nat Commun

Volume

 10

Issue

 1

Year

 2019

Pages

 2148

Abstract

 Mechanisms of lung squamous cell carcinoma (LSCC) development are poorly understood. Here, we report that JNK1/2 activities attenuate Lkb1-deficiency-driven LSCC initiation and progression through repressing DeltaNp63 signaling. In vivo Lkb1 ablation alone is sufficient to induce LSCC development by reducing MKK7 levels and JNK1/2 activities, independent of the AMPKalpha and mTOR pathways. JNK1/2 activities is positively regulated by MKK7 during LSCC development. Pharmaceutically elevated JNK1/2 activities abates Lkb1 dependent LSCC formation while compound mutations of Jnk1/2 and Lkb1 further accelerate LSCC progression. JNK1/2 is inactivated in a substantial proportion of human LSCC and JNK1/2 activities positively correlates with survival rates of lung, cervical and head and neck squamous cell carcinoma patients. These findings not only determine a suppressive role of the stress response regulators JNK1/2 on LSCC development by acting downstream of the key LSCC suppresser Lkb1, but also demonstrate activating JNK1/2 activities as a therapeutic approach against LSCC.

Links

 J:275571 – MGI References
31089135 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma Lung

37.5
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma Lung

8.3
B6;129-Scgb1a1tm1(icre)Fjd/? Trp53tm1Brn Lung adenocarcinoma Lung

10
B6;129-Errfi1tm1Jwj Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma Lung

0
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Smad4tm1Rob Lung adenocarcinoma Lung

0
B6;129-Krastm4Tyj/? Lung adenocarcinoma Lung

0
B6;129-Stk11tm1Rdp Lung adenocarcinoma Lung

0
B6;129-Trp53tm1Brn Lung adenocarcinoma Lung

0
B6;129-Errfi1tm1Jwj Lung adenocarcinoma Lung

0
B6;129-Ptentm1Hwu Lung adenocarcinoma Lung

0
B6;129-Smad4tm1Rob Lung adenocarcinoma Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma Lung

22.2 - 33.3
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma
  • anisomycin
 Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung adenocarcinoma Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung adenocarcinoma
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma Lung

22.2 - 41.7
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma
  • anisomycin
 Lung

10
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma Lung

23.8
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - mixed Lung

8.9
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma - mixed Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Trp53tm1Brn Lung adenocarcinoma - mixed Lung

0
B6;129-Errfi1tm1Jwj Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma - mixed Lung

0
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma - mixed Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Smad4tm1Rob Lung adenocarcinoma - mixed Lung

0
B6;129-Krastm4Tyj/? Lung adenocarcinoma - mixed Lung

0
B6;129-Stk11tm1Rdp Lung adenocarcinoma - mixed Lung

0
B6;129-Trp53tm1Brn Lung adenocarcinoma - mixed Lung

0
B6;129-Errfi1tm1Jwj Lung adenocarcinoma - mixed Lung

0
B6;129-Ptentm1Hwu Lung adenocarcinoma - mixed Lung

0
B6;129-Smad4tm1Rob Lung adenocarcinoma - mixed Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - mixed Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - mixed Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - papillary Lung

25
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma - papillary Lung

8.3
B6;129-Scgb1a1tm1(icre)Fjd/? Trp53tm1Brn Lung adenocarcinoma - papillary Lung

10
B6;129-Errfi1tm1Jwj Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma - papillary Lung

0
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma - papillary Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Smad4tm1Rob Lung adenocarcinoma - papillary Lung

0
B6;129-Krastm4Tyj/? Lung adenocarcinoma - papillary Lung

0
B6;129-Stk11tm1Rdp Lung adenocarcinoma - papillary Lung

0
B6;129-Trp53tm1Brn Lung adenocarcinoma - papillary Lung

0
B6;129-Errfi1tm1Jwj Lung adenocarcinoma - papillary Lung

0
B6;129-Ptentm1Hwu Lung adenocarcinoma - papillary Lung

0
B6;129-Smad4tm1Rob Lung adenocarcinoma - papillary Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - papillary Lung

22.2
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - papillary Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - solid Lung

1.8
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma - solid Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Trp53tm1Brn Lung adenocarcinoma - solid Lung

0
B6;129-Errfi1tm1Jwj Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma - solid Lung

0
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma - solid Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Smad4tm1Rob Lung adenocarcinoma - solid Lung

0
B6;129-Krastm4Tyj/? Lung adenocarcinoma - solid Lung

0
B6;129-Stk11tm1Rdp Lung adenocarcinoma - solid Lung

0
B6;129-Trp53tm1Brn Lung adenocarcinoma - solid Lung

0
B6;129-Errfi1tm1Jwj Lung adenocarcinoma - solid Lung

0
B6;129-Ptentm1Hwu Lung adenocarcinoma - solid Lung

0
B6;129-Smad4tm1Rob Lung adenocarcinoma - solid Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - solid Lung

11.1
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - solid Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - squamous Lung

10.7
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma - squamous Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Trp53tm1Brn Lung adenocarcinoma - squamous Lung

0
B6;129-Errfi1tm1Jwj Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma - squamous Lung

0
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma - squamous Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Smad4tm1Rob Lung adenocarcinoma - squamous Lung

0
B6;129-Krastm4Tyj/? Lung adenocarcinoma - squamous Lung

0
B6;129-Stk11tm1Rdp Lung adenocarcinoma - squamous Lung

0
B6;129-Trp53tm1Brn Lung adenocarcinoma - squamous Lung

0
B6;129-Errfi1tm1Jwj Lung adenocarcinoma - squamous Lung

0
B6;129-Ptentm1Hwu Lung adenocarcinoma - squamous Lung

0
B6;129-Smad4tm1Rob Lung adenocarcinoma - squamous Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - squamous Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - squamous
  • anisomycin
 Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung adenocarcinoma - squamous Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung adenocarcinoma - squamous
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - squamous Lung

0 - 16.7
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenocarcinoma - squamous
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Lung adenocarcinoma - squamous Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenoma Lung

8.9
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung adenoma Lung

16.7
B6;129-Scgb1a1tm1(icre)Fjd/? Trp53tm1Brn Lung adenoma Lung

0
B6;129-Errfi1tm1Jwj Scgb1a1tm1(icre)Fjd/? Lung adenoma Lung

8.3
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung adenoma Lung

37.5
B6;129-Scgb1a1tm1(icre)Fjd/? Smad4tm1Rob Lung adenoma Lung

0
B6;129-Krastm4Tyj/? Lung adenoma Lung

0
B6;129-Stk11tm1Rdp Lung adenoma Lung

0
B6;129-Trp53tm1Brn Lung adenoma Lung

0
B6;129-Errfi1tm1Jwj Lung adenoma Lung

0
B6;129-Ptentm1Hwu Lung adenoma Lung

0
B6;129-Smad4tm1Rob Lung adenoma Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenoma Lung

0 - 22.2
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenoma
  • anisomycin
 Lung

11.1 - 25
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung adenoma Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung adenoma
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenoma Lung

0 - 8.3
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung adenoma
  • anisomycin
 Lung

30
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Lung adenoma Lung

14.3
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung carcinoma - adenosquamous Lung

5.4
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung carcinoma - adenosquamous Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Trp53tm1Brn Lung carcinoma - adenosquamous Lung

0
B6;129-Errfi1tm1Jwj Scgb1a1tm1(icre)Fjd/? Lung carcinoma - adenosquamous Lung

0
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung carcinoma - adenosquamous Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Smad4tm1Rob Lung carcinoma - adenosquamous Lung

0
B6;129-Krastm4Tyj/? Lung carcinoma - adenosquamous Lung

0
B6;129-Stk11tm1Rdp Lung carcinoma - adenosquamous Lung

0
B6;129-Trp53tm1Brn Lung carcinoma - adenosquamous Lung

0
B6;129-Errfi1tm1Jwj Lung carcinoma - adenosquamous Lung

0
B6;129-Ptentm1Hwu Lung carcinoma - adenosquamous Lung

0
B6;129-Smad4tm1Rob Lung carcinoma - adenosquamous Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung carcinoma - adenosquamous Lung

88.9
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung carcinoma - adenosquamous
  • anisomycin
 Lung

11.1 - 25
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung carcinoma - adenosquamous Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung carcinoma - adenosquamous
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung carcinoma - adenosquamous Lung

25 - 100
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung carcinoma - adenosquamous
  • anisomycin
 Lung

100
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Lung carcinoma - adenosquamous Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung carcinoma - large cell (LCC) Lung

observed
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung carcinoma - large cell neuroendocrine Lung

observed
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung hyperplasia Lung

observed
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung hyperplasia Lung

observed
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung hyperplasia Lung

observed
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung hyperplasia - atypical - adenomatous Lung

observed
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung hyperplasia - epithelial Lung

16.1
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung hyperplasia - epithelial Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Trp53tm1Brn Lung hyperplasia - epithelial Lung

10
B6;129-Errfi1tm1Jwj Scgb1a1tm1(icre)Fjd/? Lung hyperplasia - epithelial Lung

0
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung hyperplasia - epithelial Lung

100
B6;129-Scgb1a1tm1(icre)Fjd/? Smad4tm1Rob Lung hyperplasia - epithelial Lung

0
B6;129-Krastm4Tyj/? Lung hyperplasia - epithelial Lung

0
B6;129-Stk11tm1Rdp Lung hyperplasia - epithelial Lung

0 - 6.7
B6;129-Trp53tm1Brn Lung hyperplasia - epithelial Lung

0
B6;129-Errfi1tm1Jwj Lung hyperplasia - epithelial Lung

0
B6;129-Ptentm1Hwu Lung hyperplasia - epithelial Lung

0
B6;129-Smad4tm1Rob Lung hyperplasia - epithelial Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung hyperplasia - epithelial Lung

22.2
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung hyperplasia - epithelial
  • anisomycin
 Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung hyperplasia - epithelial Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung hyperplasia - epithelial
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung hyperplasia - epithelial Lung

0 - 75
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung hyperplasia - epithelial
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Lung hyperplasia - epithelial Lung

9.5
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung lesion Lung

69.6
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung lesion Lung

25
B6;129-Scgb1a1tm1(icre)Fjd/? Trp53tm1Brn Lung lesion Lung

20
B6;129-Errfi1tm1Jwj Scgb1a1tm1(icre)Fjd/? Lung lesion Lung

8.3
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung lesion Lung

100
B6;129-Scgb1a1tm1(icre)Fjd/? Smad4tm1Rob Lung lesion Lung

0
B6;129-Krastm4Tyj/? Lung lesion Lung

0
B6;129-Stk11tm1Rdp Lung lesion Lung

0 - 6.7
B6;129-Trp53tm1Brn Lung lesion Lung

0
B6;129-Errfi1tm1Jwj Lung lesion Lung

0
B6;129-Ptentm1Hwu Lung lesion Lung

0
B6;129-Smad4tm1Rob Lung lesion Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung lesion Lung

100
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung lesion
  • anisomycin
 Lung

22.2 - 62.5
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung lesion Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung lesion
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung lesion Lung

100
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung lesion
  • anisomycin
 Lung

100
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Lung lesion Lung

42.9
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung metaplasia - squamous Lung

3.6
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung metaplasia - squamous Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Trp53tm1Brn Lung metaplasia - squamous Lung

0
B6;129-Errfi1tm1Jwj Scgb1a1tm1(icre)Fjd/? Lung metaplasia - squamous Lung

0
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung metaplasia - squamous Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Smad4tm1Rob Lung metaplasia - squamous Lung

0
B6;129-Krastm4Tyj/? Lung metaplasia - squamous Lung

0
B6;129-Stk11tm1Rdp Lung metaplasia - squamous Lung

0
B6;129-Trp53tm1Brn Lung metaplasia - squamous Lung

0
B6;129-Errfi1tm1Jwj Lung metaplasia - squamous Lung

0
B6;129-Ptentm1Hwu Lung metaplasia - squamous Lung

0
B6;129-Smad4tm1Rob Lung metaplasia - squamous Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung metaplasia - squamous Lung

0 - 11.1
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung metaplasia - squamous
  • anisomycin
 Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung metaplasia - squamous Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung metaplasia - squamous
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung metaplasia - squamous Lung

0 - 25
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung metaplasia - squamous
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Lung metaplasia - squamous Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung normal tissue (control) Lung

not applicable
B6;129-Stk11tm1Rdp Lung normal tissue (control) Lung

not applicable
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung preneoplastic lesion Lung

17.9
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung preneoplastic lesion Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Trp53tm1Brn Lung preneoplastic lesion Lung

10
B6;129-Errfi1tm1Jwj Scgb1a1tm1(icre)Fjd/? Lung preneoplastic lesion Lung

0
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung preneoplastic lesion Lung

100
B6;129-Scgb1a1tm1(icre)Fjd/? Smad4tm1Rob Lung preneoplastic lesion Lung

0
B6;129-Krastm4Tyj/? Lung preneoplastic lesion Lung

0
B6;129-Stk11tm1Rdp Lung preneoplastic lesion Lung

0 - 6.7
B6;129-Trp53tm1Brn Lung preneoplastic lesion Lung

0
B6;129-Errfi1tm1Jwj Lung preneoplastic lesion Lung

0
B6;129-Ptentm1Hwu Lung preneoplastic lesion Lung

0
B6;129-Smad4tm1Rob Lung preneoplastic lesion Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung preneoplastic lesion Lung

22.2
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung preneoplastic lesion
  • anisomycin
 Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung preneoplastic lesion Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung preneoplastic lesion
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung preneoplastic lesion Lung

0 - 75
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung preneoplastic lesion
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Lung preneoplastic lesion Lung

9.5
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung squamous cell carcinoma Lung

16.1
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung squamous cell carcinoma Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Trp53tm1Brn Lung squamous cell carcinoma Lung

0
B6;129-Errfi1tm1Jwj Scgb1a1tm1(icre)Fjd/? Lung squamous cell carcinoma Lung

0
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung squamous cell carcinoma Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Smad4tm1Rob Lung squamous cell carcinoma Lung

0
B6;129-Krastm4Tyj/? Lung squamous cell carcinoma Lung

0
B6;129-Stk11tm1Rdp Lung squamous cell carcinoma Lung

0
B6;129-Trp53tm1Brn Lung squamous cell carcinoma Lung

0
B6;129-Errfi1tm1Jwj Lung squamous cell carcinoma Lung

0
B6;129-Ptentm1Hwu Lung squamous cell carcinoma Lung

0
B6;129-Smad4tm1Rob Lung squamous cell carcinoma Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung squamous cell carcinoma Lung

44.4 - 88.9
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung squamous cell carcinoma
  • anisomycin
 Lung

22.2 - 25
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung squamous cell carcinoma Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung squamous cell carcinoma
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung squamous cell carcinoma Lung

33.3 - 100
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung squamous cell carcinoma
  • anisomycin
 Lung

50
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Lung squamous cell carcinoma Lung

0
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung tumor Lung

58.9
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung tumor Lung

25
B6;129-Scgb1a1tm1(icre)Fjd/? Trp53tm1Brn Lung tumor Lung

10
B6;129-Errfi1tm1Jwj Scgb1a1tm1(icre)Fjd/? Lung tumor Lung

8.3
B6;129-Krastm4Tyj/? Scgb1a1tm1(icre)Fjd/? Lung tumor Lung

37.5
B6;129-Scgb1a1tm1(icre)Fjd/? Smad4tm1Rob Lung tumor Lung

0
B6;129-Krastm4Tyj/? Lung tumor Lung

0
B6;129-Stk11tm1Rdp Lung tumor Lung

0
B6;129-Trp53tm1Brn Lung tumor Lung

0
B6;129-Errfi1tm1Jwj Lung tumor Lung

0
B6;129-Ptentm1Hwu Lung tumor Lung

0
B6;129-Smad4tm1Rob Lung tumor Lung

0
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung tumor Lung

100
B6;129-Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung tumor
  • anisomycin
 Lung

22.2 - 62.5
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung tumor Lung

0
B6;129-Ptentm1Hwu Stk11tm1Rdp Lung tumor
  • anisomycin
 Lung

0
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung tumor Lung

58.3 - 100
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung tumor
  • anisomycin
 Lung

100
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Scgb1a1tm1(icre)Fjd/? Lung tumor Lung

33.3
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung tumor Lung

observed
B6;129-Mapk8tm1Rjd Mapk9tm1Flv Ptentm1Hwu Scgb1a1tm1(icre)Fjd/? Lung tumor
  • anisomycin
 Lung

observed
B6;129-Scgb1a1tm1(icre)Fjd/? Stk11tm1Rdp Lung tumor - small cell - malignant Lung

observed