Reference SummaryCellurale C, PLoS One 2010;5(8):
Title |
Role of JNK in a Trp53-dependent mouse model of breast cancer. |
Authors |
Cellurale C; Weston CR; Reilly J; Garlick DS; Jerry DJ; Sluss HK; Davis RJ |
Journal |
PLoS One |
Volume |
5 |
Issue |
8 |
Year |
2010 |
Pages |
|
Abstract |
The cJun NH2-terminal kinase (JNK) signal transduction pathway has been implicated in mammary carcinogenesis. To test the role of JNK, we examined the effect of ablation of the Jnk1 and Jnk2 genes in a Trp53-dependent model of breast cancer using BALB/c mice. We detected no defects in mammary gland development in virgin mice or during lactation and involution in control studies of Jnk1(-/-) and Jnk2(-/-) mice. In a Trp53(-/+) genetic background, mammary carcinomas were detected in 43% of control mice, 70% of Jnk1(-/-) mice, and 53% of Jnk2(-/-) mice. These data indicate that JNK1 and JNK2 are not essential for mammary carcinoma development in the Trp53(-/+) BALB/c model of breast cancer. In contrast, this analysis suggests that JNK may partially contribute to tumor suppression. This conclusion is consistent with the finding that tumor-free survival of JNK-deficient Trp53(-/+) mice was significantly reduced compared with control Trp53(-/+) mice. We conclude that JNK1 and JNK2 can act as suppressors of mammary tumor development. |
Links |
J:163993 – MGI References 20814571 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C.129S2-Trp53tm1Tyj | Blood vessel hemangiosarcoma | Blood vessel |
moderate |
||
| BALB/cJ-Mapk8tm1Flv Trp53tm1Tyj | Blood vessel hemangiosarcoma | Blood vessel |
very low - low |
||
| BALB/cJ-Mapk9tm1Flv Trp53tm1Tyj | Blood vessel hemangiosarcoma | Blood vessel |
moderate |
||
| C.129S2-Trp53tm1Tyj/+ | Blood vessel hemangiosarcoma | Blood vessel |
low |
||
| BALB/cJ-Mapk8tm1Flv Trp53tm1Tyj/+ | Blood vessel hemangiosarcoma | Blood vessel |
very low |
||
| BALB/cJ-Mapk9tm1Flv Trp53tm1Tyj/+ | Blood vessel hemangiosarcoma | Blood vessel |
0 |
||
| C.129S2-Trp53tm1Tyj | Leukocyte lymphoma | Leukocyte |
high |
||
| BALB/cJ-Mapk8tm1Flv Trp53tm1Tyj | Leukocyte lymphoma | Leukocyte |
very high |
||
| BALB/cJ-Mapk9tm1Flv Trp53tm1Tyj | Leukocyte lymphoma | Leukocyte |
high |
||
| C.129S2-Trp53tm1Tyj/+ | Leukocyte lymphoma | Leukocyte |
low |
||
| BALB/cJ-Mapk8tm1Flv Trp53tm1Tyj/+ | Leukocyte lymphoma | Leukocyte |
low |
||
| BALB/cJ-Mapk9tm1Flv Trp53tm1Tyj/+ | Leukocyte lymphoma | Leukocyte |
moderate |
||
| C.129S2-Trp53tm1Tyj | Mammary gland carcinoma | Mammary gland |
0 |
||
| BALB/cJ-Mapk8tm1Flv Trp53tm1Tyj | Mammary gland carcinoma | Mammary gland |
very low |
||
| BALB/cJ-Mapk9tm1Flv Trp53tm1Tyj | Mammary gland carcinoma | Mammary gland |
0 |
||
| C.129S2-Trp53tm1Tyj/+ | Mammary gland carcinoma | Mammary gland |
43 |
||
| BALB/cJ-Mapk8tm1Flv Trp53tm1Tyj/+ | Mammary gland carcinoma | Mammary gland |
70 |
||
| BALB/cJ-Mapk9tm1Flv Trp53tm1Tyj/+ | Mammary gland carcinoma | Mammary gland |
53 |
||
| C.129S2-Trp53tm1Tyj | Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
moderate |
||
| BALB/cJ-Mapk8tm1Flv Trp53tm1Tyj | Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
very low - low |
||
| BALB/cJ-Mapk9tm1Flv Trp53tm1Tyj | Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
moderate |
||
| C.129S2-Trp53tm1Tyj/+ | Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
low |
||
| BALB/cJ-Mapk8tm1Flv Trp53tm1Tyj/+ | Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
very low |
||
| BALB/cJ-Mapk9tm1Flv Trp53tm1Tyj/+ | Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
low |
||
| C.129S2-Trp53tm1Tyj | (Unspecified organ) carcinoma | (Unspecified organ) |
0 |
||
| BALB/cJ-Mapk8tm1Flv Trp53tm1Tyj | (Unspecified organ) carcinoma | (Unspecified organ) |
very low |
||
| BALB/cJ-Mapk9tm1Flv Trp53tm1Tyj | (Unspecified organ) carcinoma | (Unspecified organ) |
0 |
||
| C.129S2-Trp53tm1Tyj/+ | (Unspecified organ) carcinoma | (Unspecified organ) |
high |
||
| BALB/cJ-Mapk8tm1Flv Trp53tm1Tyj/+ | (Unspecified organ) carcinoma | (Unspecified organ) |
very high |
||
| BALB/cJ-Mapk9tm1Flv Trp53tm1Tyj/+ | (Unspecified organ) carcinoma | (Unspecified organ) |
53 |
||
| C.129S2-Trp53tm1Tyj | (Unspecified organ) tumor | (Unspecified organ) |
100 |
||
| BALB/cJ-Mapk8tm1Flv Trp53tm1Tyj | (Unspecified organ) tumor | (Unspecified organ) |
100 |
||
| BALB/cJ-Mapk9tm1Flv Trp53tm1Tyj | (Unspecified organ) tumor | (Unspecified organ) |
100 |
||
| BALB/cJ | (Unspecified organ) tumor | (Unspecified organ) |
0 |
||
| C.129S1-Mapk8tm1Flv | (Unspecified organ) tumor | (Unspecified organ) |
0 |
||
| C.129S2-Mapk9tm1Flv | (Unspecified organ) tumor | (Unspecified organ) |
0 |
||
| C.129S2-Trp53tm1Tyj/+ | (Unspecified organ) tumor | (Unspecified organ) |
100 |
||
| BALB/cJ-Mapk8tm1Flv Trp53tm1Tyj/+ | (Unspecified organ) tumor | (Unspecified organ) |
100 |
||
| BALB/cJ-Mapk9tm1Flv Trp53tm1Tyj/+ | (Unspecified organ) tumor | (Unspecified organ) |
100 |