Reference SummaryRyan J, J Natl Cancer Inst 1987 Dec;79(6):1351-7
Title |
KRAS2 as a genetic marker for lung tumor susceptibility in inbred mice. | ||||||
Authors |
Ryan J; Barker PE; Nesbitt MN; Ruddle FH | ||||||
Journal |
J Natl Cancer Inst | ||||||
Volume |
79 | ||||||
Issue |
6 | ||||||
Year |
1987 | ||||||
Pages |
1351-7 | ||||||
Abstract |
An Eco-RI restriction fragment length polymorphism occurring in a DNA fragment containing the first exon of the murine KRAS2 gene was shown to correlate with the inherited susceptibility of inbred strains of mice to urethan (CAS: 51-79-6)-induced pulmonary adenomas. Eco-RI digestion of murine DNA yielded four KRAS2-specific fragments. Polymorphic variation occurred in the smallest molecular-weight fragment with alleles of either 0.70 or 0.55 kb in size. Genotyping of 14 inbred strains of mice revealed a correlation between KRAS2 Eco-RI polymorphic variation and the differential susceptibility among inbred strains to development of pulmonary adenomas. Strains with a high incidence of pulmonary adenomas, either spontaneously occurring or in response to carcinogen induction, had the 0.55-kb KRAS2 allele whereas adenoma-resistant strains had the 0.70-kb allele. Analysis of a series of recombinant inbred strains (AXB, BXA) that developed from reciprocal crosses between a highly susceptible strain (A/J) and a highly resistant strain (C57BL/6J) revealed a statistically significant threefold difference in lung tumor susceptibility on the basis of KRAS2 genotype. Further analysis of individual F2 mice of a C57BL/6 female X A/J male cross also demonstrated a threefold difference in tumor susceptibility on the basis of KRAS2 allelic variation. | ||||||
Links |
J:17778 – MGI References 2891865 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
AXB1 | Lung adenoma |
|
Lung |
observed |
|
AXB2 | Lung adenoma |
|
Lung |
observed |
|
AXB3 | Lung adenoma |
|
Lung |
observed |
|
AXB4 | Lung adenoma |
|
Lung |
observed |
|
AXB5 | Lung adenoma |
|
Lung |
observed |
|
AXB6 | Lung adenoma |
|
Lung |
observed |
|
AXB7 | Lung adenoma |
|
Lung |
observed |
|
AXB8 | Lung adenoma |
|
Lung |
observed |
|
AXB9 | Lung adenoma |
|
Lung |
observed |
|
AXB10 | Lung adenoma |
|
Lung |
observed |
|
AXB11 | Lung adenoma |
|
Lung |
observed |
|
AXB12 | Lung adenoma |
|
Lung |
observed |
|
AXB13 | Lung adenoma |
|
Lung |
observed |
|
AXB14 | Lung adenoma |
|
Lung |
observed |
|
AXB15 | Lung adenoma |
|
Lung |
observed |
|
AXB17 | Lung adenoma |
|
Lung |
observed |
|
AXB19 | Lung adenoma |
|
Lung |
observed |
|
AXB20 | Lung adenoma |
|
Lung |
observed |
|
AXB21 | Lung adenoma |
|
Lung |
observed |
|
AXB22 | Lung adenoma |
|
Lung |
observed |
|
AXB23 | Lung adenoma |
|
Lung |
observed |
|
AXB24 | Lung adenoma |
|
Lung |
observed |
|
BXA1 | Lung adenoma |
|
Lung |
observed |
|
BXA2 | Lung adenoma |
|
Lung |
observed |
|
BXA4 | Lung adenoma |
|
Lung |
observed |
|
BXA8 | Lung adenoma |
|
Lung |
observed |
|
BXA9 | Lung adenoma |
|
Lung |
observed |
|
BXA10 | Lung adenoma |
|
Lung |
observed |
|
BXA12 | Lung adenoma |
|
Lung |
observed |
|
BXA13 | Lung adenoma |
|
Lung |
observed |
|
BXA14 | Lung adenoma |
|
Lung |
observed |
|
BXA16 | Lung adenoma |
|
Lung |
observed |
|
BXA17 | Lung adenoma |
|
Lung |
observed |
|
BXA18 | Lung adenoma |
|
Lung |
observed |
|
BXA19 | Lung adenoma |
|
Lung |
observed |
|
BXA20 | Lung adenoma |
|
Lung |
observed |
|
BXA22 | Lung adenoma |
|
Lung |
observed |
|
BXA23 | Lung adenoma |
|
Lung |
observed |
|
BXA24 | Lung adenoma |
|
Lung |
observed |
|
BXA25 | Lung adenoma |
|
Lung |
observed |
|
(C57BL/6J x A/J)F2 | Lung adenoma |
|
Lung |
observed |
|
C57BL/6J x B6AF1 | Lung adenoma |
|
Lung |
observed |
|
A/J | Lung tumor | Lung |
90 |
||
A/HeJ | Lung tumor | Lung |
90 |
||
SWR/J | Lung tumor | Lung |
90 |
||
BALB/cJ | Lung tumor | Lung |
40.0 - 50.0 |
||
CBA/J | Lung tumor | Lung |
20 |
||
RF/J | Lung tumor | Lung |
40 |
||
C3H/HeJ | Lung tumor | Lung |
5.0 - 10.0 |
||
C57L/J | Lung tumor | Lung |
1 |
||
C57BL/6J | Lung tumor | Lung |
1 |
||
DBA/2J | Lung tumor | Lung |
5.0 - 10.0 |
||
SJL/J | Lung tumor | Lung |
5 |
||
AKR/J | Lung tumor | Lung |
5 |