Reference SummaryKim JS, Exp Anim 1997 Oct;46(4):303-6
Title |
Subcapsular cell hyperplasia and mast cell infiltration in the adrenal cortex of mice: comparative study in 7 inbred strains. |
Authors |
Kim JS; Kubota H; Kiuchi Y; Doi K; Saegusa J |
Journal |
Exp Anim |
Volume |
46 |
Issue |
4 |
Year |
1997 |
Pages |
303-6 |
Abstract |
Subcapsular cell hyperplasia (SCH) in the adrenal cortex of aged mice (13-15 months old) was frequent in both sexes of BALB/c, C3H/He, DBA/2J and IQI/Jic mice and in the females of A/J and C57BL/6, although the incidence and severity of SCH were considerably different among mouse strains. Mast cells were closely associated with SCH in the A/J, BALB/c, C57BL/6, DBA/2J and IQI/Jic mice, but not in the C3H/He strain. Compared with other strains, IQI/Jic mice had a significantly larger number of mast cells in the adrenal glands. Our findings suggest that mast cells may participate in the development of SCH, and IQI/Jic would be suitable for studying the pathogenesis of SCH and the role of mast cells in this lesion. |
Links |
J:44011 – MGI References 9353639 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| A/J | Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Cortex |
20 - 60 |
||
| BALB/c | Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Cortex |
93 - 100 |
||
| C3H/He | Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Cortex |
100 |
||
| C57BL/6 | Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Cortex |
0 - 87 |
||
| DBA/2J | Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Cortex |
67 - 100 |
||
| IQI/Jic | Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Cortex |
87.5 - 100 |
||
| WHT/Ht | Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Cortex |
0 - 7.7 |