Strain SummaryC57BL/6
Strain Name |
C57BL/6 |
Strain Type(s) |
inbred |
Strain Synonym(s) |
B6 • B6 wild-type • C57 • C57/B16 • C57B1/6 • C57BL • C57Bl6 • C57BL6 • C57BL/6 wild-type • C57BL/6 WT • p53+/+ • pure C57BL/6 • wild-type • wild type C57BL/6 • WT |
Description |
Substrain not specified. |
Strain Links |
• Festing's List of Inbred Strains |
| Frequency | ||||||||
|---|---|---|---|---|---|---|---|---|
| Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
| Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Cortex |
87 |
0 |
References: Kim JS, Exp Anim 1997 Oct;46(4):303-6 |
||||
| Blood vessel hemangiosarcoma | Blood vessel |
observed |
References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105 |
|||||
| CNS - Brain - Astrocyte astrocytoma | CNS - Brain - Astrocyte |
0 |
References: Reilly KM, Nat Genet 2000 Sep;26(1):109-13 ⋅ Weissenberger J, Oncogene 1997 May 1;14(17):2005-13 |
|||||
| CNS - Brain glioma | CNS - Brain | Moloney Murine Leukemia Virus (MoMuLV) containing Pdgfb ⋅ Moloney Murine Leukemia helper virus |
observed |
References: Johansson FK, Proc Natl Acad Sci U S A 2004 Aug 3;101(31):11334-7 |
||||
| CNS - Brain tumor | CNS - Brain | MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV) ⋅ murine retrovirus containing human PDGFB cDNA |
43 |
References: Uhrbom L, Cancer Res 1998 Dec 1;58(23):5275-9 |
||||
| CNS - Brain tumor | CNS - Brain | MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV) |
0 |
References: Uhrbom L, Cancer Res 1998 Dec 1;58(23):5275-9 |
||||
| Connective tissue - Fibroblast fibrosarcoma | Connective tissue - Fibroblast |
0 |
References: Zoch A, PLoS One 2015;10(8):e0129151 |
|||||
| Esophagus tumor | Esophagus |
0 |
References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S |
|||||
| Esophagus tumor | Esophagus | rebamipide |
0 |
References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S |
||||
| Esophagus tumor | Esophagus | N-ethyl-N'-nitro-N-nitroguanidine (ENNG) |
0 |
References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S |
||||
| Esophagus tumor | Esophagus | N-ethyl-N'-nitro-N-nitroguanidine (ENNG) ⋅ rebamipide |
0 |
References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S |
||||
| Gallbladder normal tissue (control) | Gallbladder |
not applicable |
References: Sundberg J, Personal Communication 1997;(): 5 pathology image(s) |
|||||
| Intestine - Large Intestine - Colon hyperplasia | Intestine - Large Intestine - Colon | piroxicam |
observed |
References: Ritland SR, Carcinogenesis 1999 Jan;20(1):51-8 |
||||
| Intestine - Large Intestine - Colon tumor - malignant | Intestine - Large Intestine - Colon | cesium-137 |
4.0 |
References: Mahdi AH, Cancer Res 2018 Jul 15;78(14):3969-3981 |
||||
| Intestine - Small Intestine - Duodenum adenocarcinoma | Intestine - Small Intestine - Duodenum | N-ethyl-N'-nitro-N-nitroguanidine (ENNG) |
67 |
References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S |
||||
| Intestine - Small Intestine - Duodenum adenocarcinoma | Intestine - Small Intestine - Duodenum | N-ethyl-N'-nitro-N-nitroguanidine (ENNG) ⋅ rebamipide |
42 - 55 |
References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S |
||||
| Intestine - Small Intestine - Duodenum tumor | Intestine - Small Intestine - Duodenum |
0 |
References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S |
|||||
| Intestine - Small Intestine - Duodenum tumor | Intestine - Small Intestine - Duodenum | rebamipide |
0 |
References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S |
||||
| Intestine adenoma | Intestine |
0 |
References: Sansom OJ, Cancer Res 2001 Oct 1;61(19):7060-4 |
|||||
| Intestine adenoma | Intestine | aspirin (acetylsalicylic acid) (ASA) |
0 |
References: Sansom OJ, Cancer Res 2001 Oct 1;61(19):7060-4 |
||||
| Kidney adenocarcinoma | Kidney |
0 |
References: Zoch A, PLoS One 2015;10(8):e0129151 |
|||||
| Kidney cyst | Kidney |
5.56 |
References: Zoch A, PLoS One 2015;10(8):e0129151 |
|||||
| Leukocyte - Lymphocyte leukemia | Lymphoid tissue |
observed |
References: Stevenson WS, Proc Natl Acad Sci U S A 2010 Sep 21;107(38):16625-30 |
|||||
| Leukocyte - Lymphocyte leukemia - lymphocytic | Leukocyte - Lymphocyte |
2 |
References: Festing MFW, Mouse Genome 1996;94(3):523-677 |
|||||
| Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
10 |
22 |
References: Mahler JF, Toxicol Pathol 1996 Nov-Dec;24(6):710-6 |
||||
| Leukocyte leukemia | Leukocyte |
7.0 - 16.0 |
7 |
References: Festing MFW, Mouse Genome 1996;94(3):523-677 ⋅ Staats J, Cancer Res 1985 Mar;45(3):945-77 |
||||
| Leukocyte lymphoma | Leukocyte | A-MuLV - Abelson murine leukemia virus (A-MuLV-P160) |
4.9 - 80 |
References: Risser R, Curr Top Microbiol Immunol 1985;122():162-8 |
||||
| Leukocyte lymphoma | Leukocyte | MoMuLV - Moloney murine leukemia virus (M-MuLV) (MMLV) |
0 - 33 |
References: Risser R, Curr Top Microbiol Immunol 1985;122():162-8 |
||||
| Leukocyte lymphoma | Leukocyte | methylcholanthrene (MCA) |
high |
References: Festing MFW, Mouse Genome 1996;94(3):523-677 |
||||
| Leukocyte lymphoma | Leukocyte | vinyl carbamate (VC) |
100 |
References: Devereux TR, Mol Carcinog 1993;8(3):177-85 |
||||
| Leukocyte lymphoma | Leukocyte |
5.56 |
References: Zoch A, PLoS One 2015;10(8):e0129151 |
|||||
| Leukocyte lymphoma | Thymus | cesium-137 |
24 |
20 |
References: Mahdi AH, Cancer Res 2018 Jul 15;78(14):3969-3981 |
|||
| Liver adenoma | Liver |
0 |
References: Dass SB, Cancer Lett 1999 Aug 23;143(1):81-5 |
|||||
| Liver adenoma | Liver | dimethylnitrosamine (DMN) |
33.3 - 76.5 |
References: Dass SB, Cancer Lett 1999 Aug 23;143(1):81-5 |
||||
| Liver adenoma | Liver | 6-nitrochrysene (6-NC) |
83.3 - 88.9 |
References: Dass SB, Cancer Lett 1999 Aug 23;143(1):81-5 |
||||
| Liver adenoma | Liver | 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) |
5.6 - 7.1 |
References: Dass SB, Cancer Lett 1999 Aug 23;143(1):81-5 |
||||
| Liver hepatocellular carcinoma | Liver |
0 |
References: Stevenson WS, Proc Natl Acad Sci U S A 2010 Sep 21;107(38):16625-30 |
|||||
| Liver hepatocellular carcinoma | Liver | radiation - unspecified type |
11.11 |
References: Stevenson WS, Proc Natl Acad Sci U S A 2010 Sep 21;107(38):16625-30 |
||||
| Liver hepatoma | Liver | radiation - unspecified type |
high |
References: Staats J, Cancer Res 1985 Mar;45(3):945-77 |
||||
| Liver hepatoma | Liver |
11.11 |
References: Zoch A, PLoS One 2015;10(8):e0129151 |
|||||
| Liver preneoplastic lesion | Liver | diethylnitrosamine (DEN) |
observed |
References: Finnberg N, Cancer Lett 2004 Apr 30;207(2):149-55 |
||||
| Lung adenocarcinoma | Lung | 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) |
observed |
References: Devereux TR, Mol Carcinog 1993;8(3):177-85 |
||||
| Lung adenocarcinoma | Lung | vinyl carbamate (VC) |
observed |
References: Devereux TR, Mol Carcinog 1993;8(3):177-85 |
||||
| Lung adenocarcinoma | Lung |
0 |
References: Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70 |
|||||
| Lung adenocarcinoma | Lung | benzo[a]pyrene (BP) (BaP) (B[a]P) |
42 |
References: Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70 |
||||
| Lung adenoma | Lung | vinyl carbamate (VC) |
observed |
References: Devereux TR, Mol Carcinog 1993;8(3):177-85 |
||||
| Lung adenoma | Lung |
0 |
5.56 |
References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20 ⋅ Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70 ⋅ Zoch A, PLoS One 2015;10(8):e0129151 |
||||
| Lung adenoma | Lung | benzo[a]pyrene (BP) (BaP) (B[a]P) |
0 |
References: Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70 |
||||
| Lung adenoma | Lung | mainstream cigarette smoke (MCS) |
10 |
References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20 |
||||
| Lung carcinoma | Lung | mainstream cigarette smoke (MCS) |
0 |
References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20 |
||||
| Lung carcinoma | Lung |
0 |
References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20 |
|||||
| Lung hyperplasia | Lung | benzo[a]pyrene (BP) (BaP) (B[a]P) |
observed |
References: Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70 |
||||
| Lung hyperplasia | Lung |
observed |
References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20 |
|||||
| Lung hyperplasia | Lung | mainstream cigarette smoke (MCS) |
observed |
References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20 |
||||
| Lung papilloma | Lung |
0 |
References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20 |
|||||
| Lung papilloma | Lung | mainstream cigarette smoke (MCS) |
0 |
References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20 |
||||
| Lung squamous cell carcinoma | Lung |
0 |
References: Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70 |
|||||
| Lung squamous cell carcinoma | Lung | benzo[a]pyrene (BP) (BaP) (B[a]P) |
23 |
References: Kim SH, Anticancer Res 1996 Jan-Feb;16(1):465-70 |
||||
| Lung tumor | Lung |
0 - 4.4 |
1 |
References: D'Agostini F, Int J Oncol 2001 Mar;18(3):607-15 ⋅ Devereux TR, Mol Carcinog 1993;8(3):177-85 ⋅ Festing MFW, Mouse Genome 1996;94(3):523-677 ⋅ Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20 |
||||
| Lung tumor | Lung | N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU) |
observed |
References: Festing MFW, Mouse Genome 1996;94(3):523-677 |
||||
| Lung tumor | Lung | N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU) ⋅ beta-naphthoflavone (betaNF) |
observed |
References: Festing MFW, Mouse Genome 1996;94(3):523-677 |
||||
| Lung tumor | Lung | environmental cigarette smoke (ECS) |
0 |
References: D'Agostini F, Int J Oncol 2001 Mar;18(3):607-15 |
||||
| Lung tumor | Lung | environmental cigarette smoke (ECS) ⋅ N-acetyl-L-cysteine (NAC) |
0 |
References: D'Agostini F, Int J Oncol 2001 Mar;18(3):607-15 |
||||
| Lung tumor | Lung | 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) |
18 |
References: Devereux TR, Mol Carcinog 1993;8(3):177-85 |
||||
| Lung tumor | Lung | vinyl carbamate (VC) |
46 |
References: Devereux TR, Mol Carcinog 1993;8(3):177-85 |
||||
| Lung tumor | Lung | Adenovirus - recombinant, expressing human alkaline phosphatase ⋅ Adenovirus - recombinant, expressing Jaagsiekte sheep retrovirus envelope protein |
50 |
References: Wootton SK, Nature 2005 Apr 14;434(7035):904-7 |
||||
| Lung tumor | Lung | Adenovirus - recombinant, expressing Jaagsiekte sheep retrovirus envelope protein ⋅ Adenovirus - recombinant, expressing human alkaline phosphatase |
0 |
References: Wootton SK, Nature 2005 Apr 14;434(7035):904-7 |
||||
| Lung tumor | Lung | mainstream cigarette smoke (MCS) |
observed - 10 |
References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20 |
||||
| Lymphoid tissue lymphoma | Lymphoid tissue |
0 |
References: Batten M, J Immunol 2004 Jan 15;172(2):812-22 |
|||||
| Mammary gland adenocarcinoma | Mammary gland |
1 |
References: Festing MFW, Mouse Genome 1996;94(3):523-677 |
|||||
| Mammary gland normal tissue (control) | Mammary gland |
not applicable |
References: Pfefferle AD, Genome Biol 2013;14(11):R125 |
|||||
| Mammary gland tumor | Mammary gland |
very low - low |
References: Staats J, Companion to Mouse News Lett No. 21 1959;(): |
|||||
| Mammary gland tumor | Mammary gland | cesium-137 |
4.0 - 8.0 |
References: Mahdi AH, Cancer Res 2018 Jul 15;78(14):3969-3981 |
||||
| Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast | 3-methylcholanthrene (MCA) (3-MC) |
observed |
References: Festing MFW, Mouse Genome 1996;94(3):523-677 |
||||
| Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
observed |
References: Stevenson WS, Proc Natl Acad Sci U S A 2010 Sep 21;107(38):16625-30 |
|||||
| Ovary tumor | Ovary | Ad5-CMV-Cre (AdCre) (AdCMVCre) |
0 |
References: Wu R, Cancer Cell 2007 Apr;11(4):321-33 |
||||
| Ovary tumor - malignant | Ovary | cesium-137 |
4.0 |
References: Mahdi AH, Cancer Res 2018 Jul 15;78(14):3969-3981 |
||||
| Pancreas normal tissue (control) | Pancreas |
not applicable |
References: Sundberg J, Personal Communication 1997;(): 4 pathology image(s) |
|||||
| Pituitary gland tumor | Pituitary gland |
observed - 61 |
References: Murphy ED, 1966;():521-62 ⋅ Staats J, Cancer Res 1985 Mar;45(3):945-77 |
|||||
| Prostate gland normal tissue (control) | Prostate gland |
not applicable |
References: Deeb KK, Cancer Res 2007 Sep 1;67(17):8065-8080 |
|||||
| Prostate gland tumor | Prostate gland | castration |
0 |
References: Bruckheimer EM, Oncogene 2000 Nov 2;19(46):5251-8 |
||||
| Seminal vesicle normal tissue (control) | Seminal vesicle |
not applicable |
References: Deeb KK, Cancer Res 2007 Sep 1;67(17):8065-8080 |
|||||
| Skin carcinoma | Skin | 12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA) |
0 |
References: Woodworth CD, Carcinogenesis 2004 Sep;25(9):1771-8 |
||||
| Skin papilloma | Skin | 12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA) |
observed |
References: Woodworth CD, Carcinogenesis 2004 Sep;25(9):1771-8 |
||||
| Spleen normal tissue (control) | Spleen |
not applicable |
References: Sundberg J, Personal Communication 1997;(): 12 pathology image(s) |
|||||
| Stomach tumor | Stomach |
0 |
References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S |
|||||
| Stomach tumor | Stomach | rebamipide |
0 |
References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S |
||||
| Stomach tumor | Stomach | N-ethyl-N'-nitro-N-nitroguanidine (ENNG) |
0 |
References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S |
||||
| Stomach tumor | Stomach | N-ethyl-N'-nitro-N-nitroguanidine (ENNG) ⋅ rebamipide |
0 |
References: Yamane T, Dig Dis Sci 1998 Sep;43(9 Suppl):207S-211S |
||||
| Thymus normal tissue (control) | Thymus |
not applicable |
References: Sundberg J, Personal Communication 1997;(): 8 pathology image(s) |
|||||
| Thymus thymoma | Thymus | A-MuLV - Abelson murine leukemia virus (A-MuLV-P160) |
high |
References: Risser R, Curr Top Microbiol Immunol 1985;122():162-8 |
||||
| Urinary bladder dysplasia | Urinary bladder | N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) |
50 |
References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11 |
||||
| Urinary bladder hyperplasia | Urinary bladder | N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) |
observed |
References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11 |
||||
| Urinary bladder squamous cell carcinoma | Urinary bladder | N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) |
0 |
References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11 |
||||
| Urinary bladder transitional cell carcinoma | Urinary bladder | N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) |
20 |
References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11 |
||||
| (Unspecified organ) tumor | (Unspecified organ) |
0 - observed |
low |
References: Saitoh A, Oncogene 1990 Aug;5(8):1195-200 ⋅ Staats J, Cancer Res 1985 Mar;45(3):945-77 ⋅ Zoch A, PLoS One 2015;10(8):e0129151 |
||||
| (Unspecified organ) tumor | (Unspecified organ) | cesium-137 |
28 |
References: Mahdi AH, Cancer Res 2018 Jul 15;78(14):3969-3981 |
||||
| (Unspecified organ) tumor - unclassified | (Unspecified organ) | cesium-137 |
4.0 |
References: Mahdi AH, Cancer Res 2018 Jul 15;78(14):3969-3981 |
||||