Reference SummaryShimkin MB, Adv Cancer Res 1975;21():1-58

Title	Lung tumors in mice: application to carcinogenesis bioassay.
Authors	Shimkin MB; Stoner GD
Journal	Adv Cancer Res
Volume	21
Issue
Year	1975
Pages	1-58
Abstract
Links	J:23463 – MGI References 1108612 – National Library of Medicine/PubMed

Models
Strain	Model Name	Treatment Agent(s)	Organ Affected	Frequency
A	Lung adenoma		Lung	observed
A	Lung adenoma	urethane (ethyl carbamate)	Lung	observed
SWR	Lung adenoma	urethane (ethyl carbamate)	Lung	observed
A	Lung tumor	3-methylcholanthrene (MCA) (3-MC)	Lung	observed - 100
A	Lung tumor		Lung	0 - 100
A	Lung tumor	urethane (ethyl carbamate)	Lung	observed - 100
A	Lung tumor	dibenz[a,h]anthracene (1,2,5,6-dibenzanthracene)	Lung	100
A	Lung tumor	7H-dibenzo[c,g]carbazole (3,4,5,6-dibenzocarbazole) (DBC)	Lung	100
A	Lung tumor	3,4-benzopyrene (benzo[a]pyrene)	Lung	100
A	Lung tumor	dibenz[a,j]aceanthrylene (15,16-benzdehydrocholanthrene)	Lung	90
A	Lung tumor	dibenz[a,h]acridine (1,2,5,6-dibenzacridine)	Lung	92
A	Lung tumor	8-methylbenzo[c]phenanthrene (2-methyl-3,4-benzophenanthrene)	Lung	55
A	Lung tumor	7-methylbenzo[a]pyrene (4'-methyl-3,4-benzopyrene)	Lung	50
A	Lung tumor	5-methoxy-7-propylbenz[a]-anthracene (3-methoxy-10-propyl-1,2-benzanthracene)	Lung	10
A	Lung tumor	benz[a]anthracene (1,2-benzanthracene)	Lung	18
A	Lung tumor	4-o-tolylazo-o-toluidine (2-amino-5-azotoluene)	Lung	100
A	Lung tumor	2-acetylaminofluorene (AAF)	Lung	95
A	Lung tumor	N-hydroxy-2-acetylaminofluorene	Lung	84
A	Lung tumor	aflatoxin B1 (AFB₁) (AFB1)	Lung	100
A	Lung tumor	DDT	Lung	34
A	Lung tumor	triethylene melamine (TEM)	Lung	86
A	Lung tumor	thioTEPA (thio-TEPA) (TESPA)	Lung	80
A	Lung tumor	estradiol mustard	Lung	100
A	Lung tumor	beta-deoxythioguanosine	Lung	71
A	Lung tumor	isophosphamide	Lung	83
A	Lung tumor	1-propanol-3,3'-imino dimethanesulfonate	Lung	67
A	Lung tumor	phenesterin	Lung	100
A	Lung tumor	imidazole mustard	Lung	85
A	Lung tumor	aminopterin	Lung	30
A	Lung tumor	Adriamycin	Lung	25
A	Lung tumor	potassium arsenite	Lung	37.5
A	Lung tumor	emetine	Lung	37.5
A	Lung tumor	stilbamidine	Lung	24
A	Lung tumor	cortisone	Lung	29
A	Lung tumor	phenazopyridine	Lung	33
A	Lung tumor	phenformin	Lung	26
A	Lung tumor	acronycine	Lung	29
A	Lung tumor	tolbutamide	Lung	40
A	Lung tumor	cigarette smoke	Lung	64
A/He	Lung tumor		Lung	6.5 - 25
A/He	Lung tumor	urethane (ethyl carbamate)	Lung	100
A/He	Lung tumor	N-hydroxyethyl carbamate	Lung	100
A/He	Lung tumor	allyl carbamate	Lung	71
A/He	Lung tumor	N-cyanoacetylethyl carbamate	Lung	100
A/He	Lung tumor	N-acetylethyl carbamate	Lung	94
A/He	Lung tumor	isopropyl carbamate	Lung	80
A/He	Lung tumor	N-methylnaphthyl carbamate	Lung	40
A/He	Lung tumor	propyl carbamate	Lung	75
A/He	Lung tumor	N,N-dimethylolmethoxyethyl carbamate	Lung	31
A/He	Lung tumor	diethyl bicarbamate	Lung	23
A/He	Lung tumor	sec-butyl carbamate	Lung	29
A/He	Lung tumor	hexyl carbamate	Lung	25
A/He	Lung tumor	N-phenylisopropyl carbamate	Lung	10
A/He	Lung tumor	benzyl carbamate	Lung	20
A/He	Lung tumor	phenyl carbamate	Lung	25
A/He	Lung tumor	beta-chloroethyl carbamate	Lung	17
A/He	Lung tumor	beta-hydroxypropyl carbamate	Lung	21
A/He	Lung tumor	butyl carbamate	Lung	14
A/He	Lung tumor	methallyl carbamate	Lung	25
A/He	Lung tumor	beta-hydroxyethyl carbamate	Lung	50
A/He	Lung tumor	methyl carbamate	Lung	62.5
A/He	Lung tumor	3,4-dichlorophenyl-N-carbamoyl aziridine	Lung	80
A/He	Lung tumor	m-chlorophenyl-N-carbamoyl aziridine	Lung	100
A/He	Lung tumor	phenyl-N-carbamoyl aziridine	Lung	100
A/He	Lung tumor	cyclohexyl-N-carbamoyl aziridine	Lung	73
A/He	Lung tumor	p-methoxyphenyl-N-carbamoyl aziridine	Lung	62.5
A/He	Lung tumor	p-tolyl-N-carbamoyl aziridine	Lung	62.5
A/He	Lung tumor	o-ethoxyphenyl-N-carbamoyl aziridine	Lung	33
A/He	Lung tumor	p-fluorophenyl-N-carbamoyl aziridine	Lung	33
A	Lung tumor	isopropyl carbamate	Lung	90
A	Lung tumor	propyl carbamate	Lung	63
A	Lung tumor	trichloroethyl carbamate	Lung	42
A	Lung tumor	methyl carbamate	Lung	15
A	Lung tumor	butyl carbamate	Lung	12
A	Lung tumor	isoamyl carbamate	Lung	13
A	Lung tumor	chloroethyl carbamate	Lung	15
A	Lung tumor	N-methylurethane	Lung	91
A	Lung tumor	N-dimethylurethane	Lung	81
A	Lung tumor	N-ethylurethane	Lung	86
A	Lung tumor	N-diethylurethane	Lung	93
A	Lung tumor	N-propylurethane	Lung	100
A	Lung tumor	N-dipropylurethane	Lung	95
A	Lung tumor	N-isopropylurethane	Lung	100
A	Lung tumor	N-disopropylurethane	Lung	79
A	Lung tumor	N-butylurethane	Lung	32
A	Lung tumor	N-dibutylurethane	Lung	20
A	Lung tumor	N-diphenylurethane	Lung	16
A	Lung tumor	methylene diurethane	Lung	100
A	Lung tumor	ethylene diurethane	Lung	98
A	Lung tumor	ethylidene diurethane	Lung	100
GRS	Lung tumor		Lung	42
GRS	Lung tumor	urethane (ethyl carbamate)	Lung	100
O20	Lung tumor		Lung	58
O20	Lung tumor	urethane (ethyl carbamate)	Lung	100
CBA	Lung tumor		Lung	18
CBA	Lung tumor	urethane (ethyl carbamate)	Lung	38
C3H	Lung tumor		Lung	14
C3H	Lung tumor	urethane (ethyl carbamate)	Lung	21
C3H	Lung tumor	dimethylbenzanthracene (DMBA)	Lung	5.5 - 27
DBA	Lung tumor		Lung	9.0
DBA	Lung tumor	urethane (ethyl carbamate)	Lung	17
C57BL	Lung tumor		Lung	0 - 7.0
C57BL	Lung tumor	urethane (ethyl carbamate)	Lung	7.0
C57BL	Lung tumor	4-nitroquinoline-N-oxide (4-NQO)	Lung	observed
C57BL	Lung tumor	X-radiation	Lung	observed
C57BL	Lung tumor	cigarette smoke	Lung	4.0
(O20 x GRS)F1	Lung tumor	urethane (ethyl carbamate)	Lung	100
(C57 x GRS)F1	Lung tumor	urethane (ethyl carbamate)	Lung	100
(O20 x DBA)F1	Lung tumor		Lung	31 - 32
(O20 x DBA)F1	Lung tumor	urethane (ethyl carbamate)	Lung	100
(O20 x DBA)F1	Lung tumor	cigarette smoke	Lung	79
(C57 x CBA)F1	Lung tumor	urethane (ethyl carbamate)	Lung	63
(C3H x C57BL)F1	Lung tumor	urethane (ethyl carbamate)	Lung	30
BALB/c	Lung tumor		Lung	11
BALB/c	Lung tumor	urethane (ethyl carbamate)	Lung	53 - 85
BALB/c	Lung tumor	urethane (ethyl carbamate) thymectomy	Lung	very high
BALB/c	Lung tumor	urethane (ethyl carbamate) splenectomy	Lung	very high
BALB/c	Lung tumor	urethane (ethyl carbamate) cortisone	Lung	very high
BALB/c	Lung tumor	isoniazid	Lung	100
BALB/c	Lung tumor	isonicotinic acid	Lung	19
BALB/c	Lung tumor	iproniazid	Lung	35
BALB/c	Lung tumor	phenylhydrazine	Lung	53
BALB/c	Lung tumor	benzoylhydrazine	Lung	90
BALB/c	Lung tumor	2-methoxybenzoylhydrazine	Lung	95
BALB/c	Lung tumor	4-methoxybenzoylhydrazine	Lung	95
SWR	Lung tumor	methylcholanthrene (MCA)	Lung	observed
Swiss	Lung tumor	urethane (ethyl carbamate)	Lung	observed
Swiss	Lung tumor	urethane (ethyl carbamate) thymectomy	Lung	observed
Swiss	Lung tumor	urethane (ethyl carbamate) phenobarbital (PB)	Lung	observed
SWR	Lung tumor	urethane (ethyl carbamate)	Lung	91
SWR	Lung tumor	dimethylnitrosamine (DMN)	Lung	100
SWR	Lung tumor	N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)	Lung	97
SWR	Lung tumor	dibutylnitrosamine	Lung	70
SWR	Lung tumor	nitrosopiperidine	Lung	53
SWR	Lung tumor	N-acetyl-S-carbethoxycysteine	Lung	11
SWR	Lung tumor	S-carbamylcysteine	Lung	27.5
SWR	Lung tumor	S-carbobenzyloxycysteine	Lung	28
SWR	Lung tumor		Lung	28 - 45
BALB/c	Lung tumor	hydrazine sulfate	Lung	100

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Models