Reference SummaryShimkin MB, Adv Cancer Res 1975;21():1-58

Title

 Lung tumors in mice: application to carcinogenesis bioassay.

Authors

 Shimkin MB; Stoner GD

Journal

 Adv Cancer Res

Volume

 21

Issue

Year

 1975

Pages

 1-58

Abstract

Links

 J:23463 – MGI References
1108612 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
A Lung adenoma Lung

observed
A Lung adenoma
  • urethane (ethyl carbamate)
 Lung

observed
SWR Lung adenoma
  • urethane (ethyl carbamate)
 Lung

observed
A Lung tumor
  • 3-methylcholanthrene (MCA) (3-MC)
 Lung

observed - 100
A Lung tumor Lung

0 - 100
A Lung tumor
  • urethane (ethyl carbamate)
 Lung

observed - 100
A Lung tumor
  • dibenz[a,h]anthracene (1,2,5,6-dibenzanthracene)
 Lung

100
A Lung tumor
  • 7H-dibenzo[c,g]carbazole (3,4,5,6-dibenzocarbazole) (DBC)
 Lung

100
A Lung tumor
  • 3,4-benzopyrene (benzo[a]pyrene)
 Lung

100
A Lung tumor
  • dibenz[a,j]aceanthrylene (15,16-benzdehydrocholanthrene)
 Lung

90
A Lung tumor
  • dibenz[a,h]acridine (1,2,5,6-dibenzacridine)
 Lung

92
A Lung tumor
  • 8-methylbenzo[c]phenanthrene (2-methyl-3,4-benzophenanthrene)
 Lung

55
A Lung tumor
  • 7-methylbenzo[a]pyrene (4'-methyl-3,4-benzopyrene)
 Lung

50
A Lung tumor
  • 5-methoxy-7-propylbenz[a]-anthracene (3-methoxy-10-propyl-1,2-benzanthracene)
 Lung

10
A Lung tumor
  • benz[a]anthracene (1,2-benzanthracene)
 Lung

18
A Lung tumor
  • 4-o-tolylazo-o-toluidine (2-amino-5-azotoluene)
 Lung

100
A Lung tumor
  • 2-acetylaminofluorene (AAF)
 Lung

95
A Lung tumor
  • N-hydroxy-2-acetylaminofluorene
 Lung

84
A Lung tumor
  • aflatoxin B1 (AFB1) (AFB1)
 Lung

100
A Lung tumor
  • DDT
 Lung

34
A Lung tumor
  • triethylene melamine (TEM)
 Lung

86
A Lung tumor
  • thioTEPA (thio-TEPA) (TESPA)
 Lung

80
A Lung tumor
  • estradiol mustard
 Lung

100
A Lung tumor
  • beta-deoxythioguanosine
 Lung

71
A Lung tumor
  • isophosphamide
 Lung

83
A Lung tumor
  • 1-propanol-3,3'-imino dimethanesulfonate
 Lung

67
A Lung tumor
  • phenesterin
 Lung

100
A Lung tumor
  • imidazole mustard
 Lung

85
A Lung tumor
  • aminopterin
 Lung

30
A Lung tumor
  • Adriamycin
 Lung

25
A Lung tumor
  • potassium arsenite
 Lung

37.5
A Lung tumor
  • emetine
 Lung

37.5
A Lung tumor
  • stilbamidine
 Lung

24
A Lung tumor
  • cortisone
 Lung

29
A Lung tumor
  • phenazopyridine
 Lung

33
A Lung tumor
  • phenformin
 Lung

26
A Lung tumor
  • acronycine
 Lung

29
A Lung tumor
  • tolbutamide
 Lung

40
A Lung tumor
  • cigarette smoke
 Lung

64
A/He Lung tumor Lung

6.5 - 25
A/He Lung tumor
  • urethane (ethyl carbamate)
 Lung

100
A/He Lung tumor
  • N-hydroxyethyl carbamate
 Lung

100
A/He Lung tumor
  • allyl carbamate
 Lung

71
A/He Lung tumor
  • N-cyanoacetylethyl carbamate
 Lung

100
A/He Lung tumor
  • N-acetylethyl carbamate
 Lung

94
A/He Lung tumor
  • isopropyl carbamate
 Lung

80
A/He Lung tumor
  • N-methylnaphthyl carbamate
 Lung

40
A/He Lung tumor
  • propyl carbamate
 Lung

75
A/He Lung tumor
  • N,N-dimethylolmethoxyethyl carbamate
 Lung

31
A/He Lung tumor
  • diethyl bicarbamate
 Lung

23
A/He Lung tumor
  • sec-butyl carbamate
 Lung

29
A/He Lung tumor
  • hexyl carbamate
 Lung

25
A/He Lung tumor
  • N-phenylisopropyl carbamate
 Lung

10
A/He Lung tumor
  • benzyl carbamate
 Lung

20
A/He Lung tumor
  • phenyl carbamate
 Lung

25
A/He Lung tumor
  • beta-chloroethyl carbamate
 Lung

17
A/He Lung tumor
  • beta-hydroxypropyl carbamate
 Lung

21
A/He Lung tumor
  • butyl carbamate
 Lung

14
A/He Lung tumor
  • methallyl carbamate
 Lung

25
A/He Lung tumor
  • beta-hydroxyethyl carbamate
 Lung

50
A/He Lung tumor
  • methyl carbamate
 Lung

62.5
A/He Lung tumor
  • 3,4-dichlorophenyl-N-carbamoyl aziridine
 Lung

80
A/He Lung tumor
  • m-chlorophenyl-N-carbamoyl aziridine
 Lung

100
A/He Lung tumor
  • phenyl-N-carbamoyl aziridine
 Lung

100
A/He Lung tumor
  • cyclohexyl-N-carbamoyl aziridine
 Lung

73
A/He Lung tumor
  • p-methoxyphenyl-N-carbamoyl aziridine
 Lung

62.5
A/He Lung tumor
  • p-tolyl-N-carbamoyl aziridine
 Lung

62.5
A/He Lung tumor
  • o-ethoxyphenyl-N-carbamoyl aziridine
 Lung

33
A/He Lung tumor
  • p-fluorophenyl-N-carbamoyl aziridine
 Lung

33
A Lung tumor
  • isopropyl carbamate
 Lung

90
A Lung tumor
  • propyl carbamate
 Lung

63
A Lung tumor
  • trichloroethyl carbamate
 Lung

42
A Lung tumor
  • methyl carbamate
 Lung

15
A Lung tumor
  • butyl carbamate
 Lung

12
A Lung tumor
  • isoamyl carbamate
 Lung

13
A Lung tumor
  • chloroethyl carbamate
 Lung

15
A Lung tumor
  • N-methylurethane
 Lung

91
A Lung tumor
  • N-dimethylurethane
 Lung

81
A Lung tumor
  • N-ethylurethane
 Lung

86
A Lung tumor
  • N-diethylurethane
 Lung

93
A Lung tumor
  • N-propylurethane
 Lung

100
A Lung tumor
  • N-dipropylurethane
 Lung

95
A Lung tumor
  • N-isopropylurethane
 Lung

100
A Lung tumor
  • N-disopropylurethane
 Lung

79
A Lung tumor
  • N-butylurethane
 Lung

32
A Lung tumor
  • N-dibutylurethane
 Lung

20
A Lung tumor
  • N-diphenylurethane
 Lung

16
A Lung tumor
  • methylene diurethane
 Lung

100
A Lung tumor
  • ethylene diurethane
 Lung

98
A Lung tumor
  • ethylidene diurethane
 Lung

100
GRS Lung tumor Lung

42
GRS Lung tumor
  • urethane (ethyl carbamate)
 Lung

100
O20 Lung tumor Lung

58
O20 Lung tumor
  • urethane (ethyl carbamate)
 Lung

100
CBA Lung tumor Lung

18
CBA Lung tumor
  • urethane (ethyl carbamate)
 Lung

38
C3H Lung tumor Lung

14
C3H Lung tumor
  • urethane (ethyl carbamate)
 Lung

21
C3H Lung tumor
  • dimethylbenzanthracene (DMBA)
 Lung

5.5 - 27
DBA Lung tumor Lung

9.0
DBA Lung tumor
  • urethane (ethyl carbamate)
 Lung

17
C57BL Lung tumor Lung

0 - 7.0
C57BL Lung tumor
  • urethane (ethyl carbamate)
 Lung

7.0
C57BL Lung tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
 Lung

observed
C57BL Lung tumor
  • X-radiation
 Lung

observed
C57BL Lung tumor
  • cigarette smoke
 Lung

4.0
(O20 x GRS)F1 Lung tumor
  • urethane (ethyl carbamate)
 Lung

100
(C57 x GRS)F1 Lung tumor
  • urethane (ethyl carbamate)
 Lung

100
(O20 x DBA)F1 Lung tumor Lung

31 - 32
(O20 x DBA)F1 Lung tumor
  • urethane (ethyl carbamate)
 Lung

100
(O20 x DBA)F1 Lung tumor
  • cigarette smoke
 Lung

79
(C57 x CBA)F1 Lung tumor
  • urethane (ethyl carbamate)
 Lung

63
(C3H x C57BL)F1 Lung tumor
  • urethane (ethyl carbamate)
 Lung

30
BALB/c Lung tumor Lung

11
BALB/c Lung tumor
  • urethane (ethyl carbamate)
 Lung

53 - 85
BALB/c Lung tumor
  • urethane (ethyl carbamate)
  • thymectomy
 Lung

very high
BALB/c Lung tumor
  • urethane (ethyl carbamate)
  • splenectomy
 Lung

very high
BALB/c Lung tumor
  • urethane (ethyl carbamate)
  • cortisone
 Lung

very high
BALB/c Lung tumor
  • isoniazid
 Lung

100
BALB/c Lung tumor
  • isonicotinic acid
 Lung

19
BALB/c Lung tumor
  • iproniazid
 Lung

35
BALB/c Lung tumor
  • phenylhydrazine
 Lung

53
BALB/c Lung tumor
  • benzoylhydrazine
 Lung

90
BALB/c Lung tumor
  • 2-methoxybenzoylhydrazine
 Lung

95
BALB/c Lung tumor
  • 4-methoxybenzoylhydrazine
 Lung

95
SWR Lung tumor
  • methylcholanthrene (MCA)
 Lung

observed
Swiss Lung tumor
  • urethane (ethyl carbamate)
 Lung

observed
Swiss Lung tumor
  • urethane (ethyl carbamate)
  • thymectomy
 Lung

observed
Swiss Lung tumor
  • urethane (ethyl carbamate)
  • phenobarbital (PB)
 Lung

observed
SWR Lung tumor
  • urethane (ethyl carbamate)
 Lung

91
SWR Lung tumor
  • dimethylnitrosamine (DMN)
 Lung

100
SWR Lung tumor
  • N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)
 Lung

97
SWR Lung tumor
  • dibutylnitrosamine
 Lung

70
SWR Lung tumor
  • nitrosopiperidine
 Lung

53
SWR Lung tumor
  • N-acetyl-S-carbethoxycysteine
 Lung

11
SWR Lung tumor
  • S-carbamylcysteine
 Lung

27.5
SWR Lung tumor
  • S-carbobenzyloxycysteine
 Lung

28
SWR Lung tumor Lung

28 - 45
BALB/c Lung tumor
  • hydrazine sulfate
 Lung

100