Reference SummaryMahler JF, Toxicol Pathol 1996 Nov-Dec;24(6):710-6
Title |
Spontaneous lesions in aging FVB/N mice. |
Authors |
Mahler JF; Stokes W; Mann PC; Takaoka M; Maronpot RR |
Journal |
Toxicol Pathol |
Volume |
24 |
Issue |
6 |
Year |
1996 |
Pages |
710-6 |
Abstract |
The FVB/N mouse strain was created in the early 1970s and has since been used extensively in transgenic research because of its well-defined inbred background, superior reproductive performance, and prominent pronuclei of fertilized zygotes, which facilitate microinjection of DNA. Little is known, however, about the survivability and spontaneous disease of nontransgenic FVB/N mice. Therefore, the purpose of this study was to determine survival to 24 mo of age and the incidence of neoplastic and nonneoplastic disease at 14 and 24 mo of age. At 14 mo of age, the incidence of tumor-bearing mice was 13% in males (n = 45) and 26% in females (n = 98). All tumors in males and most in females at this time were alveolar-bronchiolar (AB) neoplasms of the lung. Survival to 24 mo of age was approximately 60% in both sexes (29/50 males, 71/116 females), and the incidence of mice with tumors at this time was 55% in males and 66% in females. In decreasing order of frequency, the following neoplasms were observed in > 5% of subjects: in males, lung AB tumors, liver hepatocellular tumors, subcutis neural crest tumors, and Harderian gland adenomas; in females, lung AB tumors, pituitary gland adenomas, ovarian tumors (combined types), lymphomas, histiocytic sarcomas, Harderian gland adenomas, and pheochromocytomas. Compared with other mouse strains, the observed incidences of tumors in FVB/N mice suggest a higher than usual rate of lung tumors and a lower than usual incidence of liver tumors and lymphomas. This tumor profile should be considered in the interpretation of neoplastic phenotypes in FVB/N-derived transgenic lines. |
Links |
J:38438 – MGI References 8994298 – National Library of Medicine/PubMed |
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
FVB/NHsd | Adipose tissue liposarcoma | Subcutis |
0 |
||
FVB/NTac | Adipose tissue liposarcoma | Subcutis |
0 - 1.4 |
||
(C57BL/6 x C3H)F1 | Adrenal gland - Cortex tumor | Adrenal gland - Cortex |
4 |
||
FVB/NTac | Adrenal gland - Cortex tumor | Adrenal gland - Cortex |
0 |
||
FVB/NHsd | Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
0 |
||
FVB/NTac | Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
3.6 - 6 |
||
(C57BL/6 x C3H)F1 | Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
2 |
||
FVB/NHsd | Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Subcapsular cell |
0 - 29 |
||
FVB/NTac | Adrenal gland - Subcapsular cell hyperplasia | Adrenal gland - Subcapsular cell |
14 - 83 |
||
FVB/NHsd | Blood vessel hemangioma | Blood vessel |
0 |
||
FVB/NTac | Blood vessel hemangioma | Blood vessel |
0 |
||
FVB/NTac | Blood vessel hemangioma | Ovary |
1.4 |
||
FVB/NTac | Blood vessel hemangioma | Spleen |
1.4 |
||
(C57BL/6 x C3H)F1 | Blood vessel tumor | Blood vessel |
6 |
||
FVB/NHsd | CNS - Brain - Undifferentiated cell tumor | Skin |
0 - 1.0 |
||
FVB/NTac | CNS - Brain - Undifferentiated cell tumor | Skin |
2.8 - 6.9 |
||
FVB/NTac | CNS - Brain - Undifferentiated cell tumor | Preputial gland (male) |
3.4 |
||
FVB/NHsd | Connective tissue - Fibroblast fibroma | Uterus |
1.0 |
||
FVB/NTac | Connective tissue - Fibroblast fibroma | Uterus |
0 |
||
FVB/NHsd | Eye - Harderian gland adenoma | Eye - Harderian gland |
0 |
||
FVB/NTac | Eye - Harderian gland adenoma | Eye - Harderian gland |
5.6 - 6.9 |
||
FVB/NTac | Eye - Harderian gland tumor | Eye - Harderian gland |
6 - 7 |
||
(C57BL/6 x C3H)F1 | Eye - Harderian gland tumor | Eye - Harderian gland |
4 - 5 |
||
FVB/NHsd | Gallbladder papilloma | Gallbladder |
0 |
||
FVB/NTac | Gallbladder papilloma | Gallbladder |
0 - 1.4 |
||
FVB/NTac | Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma | Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell |
5.6 - 6 |
||
FVB/NHsd | Leukocyte - Lymphocyte hyperplasia | Spleen - White pulp |
0 |
||
FVB/NTac | Leukocyte - Lymphocyte hyperplasia | Spleen - White pulp |
0 - 11 |
||
FVB/NHsd | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0 - 1.0 |
||
FVB/NTac | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0 - 6 |
||
C57BL/6 | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
10 - 22 |
||
(C57BL/6 x C3H)F1 | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0.3 - 1 |
||
FVB/NHsd | Leukocyte lymphoma | Leukocyte |
0 |
||
FVB/NTac | Leukocyte lymphoma | Leukocyte |
0 |
||
(C57BL/6 x C3H)F1 | Leukocyte lymphoma | Leukocyte |
9 - 25 |
||
FVB/NHsd | Liver hepatocellular adenoma | Liver |
0 |
||
FVB/NTac | Liver hepatocellular adenoma | Liver |
0 - 17 |
||
FVB/NHsd | Liver hepatocellular carcinoma | Liver |
0 |
||
FVB/NTac | Liver hepatocellular carcinoma | Liver |
0 - 14 |
||
FVB/NTac | Liver tumor | Liver |
0 - 21.0 |
||
(C57BL/6 x C3H)F1 | Liver tumor | Liver |
17 - 36 |
||
C57BL | Liver tumor | Liver |
5 |
||
C3H | Liver tumor | Liver |
80 |
||
FVB/NHsd | Lung - Alveolus hyperplasia | Lung - Alveolus |
1.0 - 4.4 |
||
FVB/NTac | Lung - Alveolus hyperplasia | Lung - Alveolus |
6.9 - 11 |
||
FVB/NHsd | Lung adenoma | Lung |
6.7 - 9.2 |
||
FVB/NTac | Lung adenoma | Lung |
18 - 28 |
||
FVB/NHsd | Lung carcinoma | Lung |
5.1 - 6.7 |
||
FVB/NTac | Lung carcinoma | Lung |
21 - 28 |
||
FVB/NTac | Lung tumor | Lung |
37 - 41 |
||
(C57BL/6 x C3H)F1 | Lung tumor | Lung |
7 - 18 |
||
A | Lung tumor | Lung |
100 |
||
C57BL | Lung tumor | Lung |
3 |
||
FVB/NHsd | Muscle - Smooth leiomyoma | Uterus |
1.0 |
||
FVB/NTac | Muscle - Smooth leiomyoma | Uterus |
0 |
||
FVB/NHsd | Muscle - Smooth leiomyosarcoma | Uterus |
0 |
||
FVB/NTac | Muscle - Smooth leiomyosarcoma | Uterus |
1.4 |
||
FVB/NHsd | Ovary - Germ cell teratoma | Ovary - Germ cell |
2.0 |
||
FVB/NTac | Ovary - Germ cell teratoma | Ovary - Germ cell |
1.4 |
||
FVB/NHsd | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0 |
||
FVB/NTac | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
2.8 |
||
FVB/NHsd | Ovary - Sertoli cell tumor | Ovary - Sertoli cell |
0 |
||
FVB/NTac | Ovary - Sertoli cell tumor | Ovary - Sertoli cell |
1.4 |
||
FVB/NHsd | Ovary cystadenoma | Ovary |
0 |
||
FVB/NTac | Ovary cystadenoma | Ovary |
1.4 |
||
FVB/NTac | Ovary tumor | Ovary |
7 |
||
FVB/NHsd | Pancreas - Islet of Langerhans adenoma | Pancreas - Islet of Langerhans |
0 |
||
FVB/NTac | Pancreas - Islet of Langerhans adenoma | Pancreas - Islet of Langerhans |
0 - 3.4 |
||
FVB/NHsd | Pituitary gland - Pars distalis adenoma | Pituitary gland - Pars distalis |
0 - 5.5 |
||
FVB/NTac | Pituitary gland - Pars distalis adenoma | Pituitary gland - Pars distalis |
0 - 14 |
||
FVB/NHsd | Pituitary gland - Pars distalis hyperplasia | Pituitary gland - Pars distalis |
0 - 3.3 |
||
FVB/NTac | Pituitary gland - Pars distalis hyperplasia | Pituitary gland - Pars distalis |
0 - 7.2 |
||
FVB/NTac | Pituitary gland - Pars distalis tumor | Pituitary gland - Pars distalis |
15 |
||
(C57BL/6 x C3H)F1 | Pituitary gland - Pars distalis tumor | Pituitary gland - Pars distalis |
16 |
||
FVB/NHsd | Placenta - Trophoblast choriocarcinoma | Uterus |
1.0 |
||
FVB/NTac | Placenta - Trophoblast choriocarcinoma | Uterus |
0 |
||
FVB/NHsd | Skin - Epidermis squamous cell papilloma | Skin - Epidermis |
0 |
||
FVB/NTac | Skin - Epidermis squamous cell papilloma | Skin - Epidermis |
0 - 1.4 |
||
FVB/NHsd | Testis - Leydig cell (Interstitial cell) adenoma | Testis - Leydig cell (Interstitial cell) |
0 |
||
FVB/NTac | Testis - Leydig cell (Interstitial cell) adenoma | Testis - Leydig cell (Interstitial cell) |
3.4 |
||
FVB/NHsd | Testis - Leydig cell (Interstitial cell) hyperplasia | Testis - Leydig cell (Interstitial cell) |
2.2 |
||
FVB/NTac | Testis - Leydig cell (Interstitial cell) hyperplasia | Testis - Leydig cell (Interstitial cell) |
3.4 |
||
FVB/NHsd | Thyroid gland tumor | Thyroid gland |
0 |
||
FVB/NTac | Thyroid gland tumor | Thyroid gland |
0 |