| Lymphoma Pathology |
|
|
|
|
|
|
|
|
| CASE # |
Strain |
Diagnosis |
Immunostain |
Type of Slide |
Fixative |
NOTES |
|
|
|
| 31106-A |
NFS.V |
Follicular lymphoma, spleen |
|
Histology |
10% NBF |
|
|
|
|
| 31106-A |
|
|
CD3+ |
Immunohistochemistry |
|
1:400 antigen retrieval |
|
|
|
| 31106-A |
|
|
BIOT.CD45R+++ |
Immunohistochemistry |
|
1:200 antigen retrieval |
|
|
|
| 99000951-5 |
B6;129 |
Follicular lymphoma, spleen |
|
Histology |
10% NBF |
|
|
|
|
| 99000951-5 |
|
|
CD45R+++ |
Immunohistochemistry |
|
BIO 1:100 antigen retrieval |
|
|
|
| 99000951-5 |
|
|
CD3++ |
Immunohistochemistry |
|
1:200 antigen retrieval |
|
|
|
| 99000951-8A |
B6;129 |
Follicular lymphoma, mesenteric lymph nodes and intestine
(Peyer's patches) |
|
Histology |
10% NBF |
|
|
|
|
| 00000092-8A |
B6;129 |
Follicular lymphoma, with focalhistiocytic sarcoma,
mesenteric lymph nodes |
|
Histology |
10% NBF |
|
|
|
|
| 00000092-8A |
|
|
CD45R+++ |
Immunohistochemistry |
|
1:200 antigen retrieval |
|
|
|
| 00000092-8A |
|
|
CD3++ |
Immunohistochemistry |
|
1:400 antigen retrieval |
|
|
|
| 00000092-5 |
B6;129 |
Follicular lymphoma, with focal histiocytic sarcoma,
spleen |
|
Histology |
10%NBF |
|
|
|
|
| 00000092-5 |
|
|
CD3++ |
Immunohistochemistry |
|
1:200 antigen retrieval |
|
|
|
| 00000381-8A |
B6;129 |
Follicular lymphoma, pancreatic-duodenal lymph node |
|
Histology |
10%NBF |
|
|
|
|
| 00000381-8A |
|
|
BIOT.CD45R+++ |
Immunohistochemistry |
|
1:200 antigen retrieval |
|
|
|
| 00000381-8A |
|
|
CD3++ |
Immunohistochemistry |
|
1:400 antigen retrieval |
|
|
|
| 00000381-5 |
B6;129 |
Folicular lymphoma, spleen |
|
Histology |
|
|
|
|
|
| 32525-A |
NFS.V |
Plasma cell lymphoma, anaplastic, spleen |
|
Histology |
10%NBF |
|
|
|
|
| 30923-A |
NFS.V |
Immunoblastic lymphoma (diffuse large B-cell lymphoma),
spleen |
|
Histology |
10%NBF |
|
|
|
|
| 29999A |
NFS.V |
Diffuse large B-cell lymphoma, centroblastic, spleen |
|
Histology |
10%NBF |
|
|
|
|
| 29999A |
|
|
CD3+ |
Immunohistochemistry |
|
1:400 antigen retrieval |
|
|
|
| 29999A |
|
|
BIOT.CD45R+++ |
Immunohistochemistry |
|
1:200 antigen retrieval |
|
|
|
| 32356A |
NFS.V |
Diffuse large B-cell lymphoma, centroblastic,
histiocyte-rich, spleen, lymph nodes |
|
Histology |
|
|
|
|
|
| 31213 |
NFS.V |
Diffuse large B-cell lymphoma, centroblastic,
histiocyte-rich, spleen |
|
Histology |
|
|
|
|
|
| 26490-A |
NFS.V |
Lymphoma, lymphoblastic, B-cell, lymph nodes |
|
Histology |
10%NBF |
|
|
|
|
| 26490-A |
|
|
CD3-, lung CD3+++ |
Immunohistochemistry |
|
1:400 antigen retrieval |
|
|
|
| 26490-A |
|
|
CD45R+++ |
Immunohistochemistry |
|
1:200 antigen retrieval |
|
|
|
| 98005791-2A |
B6;129-Trp53<sup>Tm1Brd</sup> |
Marginal zone hyperplasia, spleen |
|
Histology |
BOUINS |
|
|
|
|
| 32801 |
NFS.V |
Marginal zone lymphoma, spleen |
|
Histology |
|
|
|
|
|
| 32801 |
|
|
BIOT.CD45R+++ |
Immunohistochemistry |
|
1:200 antigen retrieval |
|
|
|
| 32801 |
|
|
CD3- |
Immunohistochemistry |
|
1:400 antigen retrieval |
|
|
|
| 98005351-1A |
B6;129-Trp53<sup>Tm1Brd</sup> |
Marginal zone lymphoma, spleen, advanced |
|
Histology |
BOUINS |
|
|
|
|
| 35599 |
|
Marginal zone lymphoma, spleen |
|
Histology |
|
|
|
|
|
| 35200 |
NFS.V |
lymphoblastic lymphoma |
|
Histology |
|
1:200 antigen retrieval |
|
|
|
| 98005218-2 |
B6;129-Trp53<sup>Tm1Brd</sup> |
Lymphoblastic lymphoma, thymic origin, early |
|
Histology |
10%NBF |
|
|
|
|
| 98005218-2 |
|
|
CD3 (DAKO)+++ |
Immunohistochemistry |
|
1:50 |
|
|
|
| 98105402-5 |
B6;129 |
Lymphoblastic lymphoma, thymic T-cell origin, spleen,
liver |
|
Histology |
10%NBF |
|
|
|
|
| 98105402-5 |
|
|
CD3+++ |
Immunohistochemistry |
|
1:400 antigen retrieval |
|
|
|
| 00007622-1 |
B6;129 |
Histiocytic sarcoma, liver |
|
Histology |
10%NBF |
|
|
|
|
| 00007622-1 |
|
|
CD68+++ |
Immunohistochemistry |
|
1:2,000 |
|
|
|
| 00007622-1 |
|
|
F4/80+++ |
Immunohistochemistry |
|
1:25 37C rat elite kit |
|
|
|
| 8680 |
FVB/N-Tg(PML-RARA)556Kog |
Myeloid leukemia, preleukemic, spleen |
|
Histology |
BOUINS |
|
|
|
|
| 8680 |
|
|
INOS |
Immunohistochemistry |
BOUINS |
1:2000, ON4 antigen retrieval CITR. BUFFER |
|
| 35775 |
CFW |
Myeloid leukemia, undifferentiated, without maturation,
spleen, liver, lymph node |
|
Histology |
|
|
|
|
|
| 27836-A |
NFS.V |
Erythroid leukemia, spleen, liver |
|
Histology |
10%NBF |
|
|
|
|
| 35311 |
B6;129-Trp53<sup>Tm1Brd</sup> |
Lymphoblastic lymphoma, thymic T-cell origin and marginal
zone lymphoma, spleen |
|
Histology |
|
|
|
|
|
| 35311 |
|
|
CD3+++ |
Immunohistochemistry |
|
1:400 antigen retrieval |
|
|
|
| 35311 |
|
|
BIOT.CD45R- |
Immunohistochemistry |
|
1:100 antigen retrieval |
|
|
|
| 35311 |
|
|
TDT |
Immunohistochemistry |
|
1:200 antigen retrieval EDTA |
|
|
| CD3
NORMAL |
|
|
|
Control |
|
|
|
|
|
| CD45R
NORMAL |
|
|
|
Control |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| CASE # link
connects to a Pathology Image Detail page for that sample containing details
for that image and a link to a Whole Slide Scan of that image. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Study set
created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID,
NIH), and Jerrold M. Ward (NCI, NIH) in 2001. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| This work was
supported in part with funds from the Mouse Model of Cancers Consortium,
National Cancer Institute, National Institutes of health, and by contract
N01-C056000 from the National cancer Institute. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| References |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Campo, E., et
al., 2011. The 2008 WHO classification of lymphoid neoplasms and beyond:
evolving concepts and practical applications. Blood 117: 5019-5032. |
|
|
|
|
|
| Kogan, S. C., et al., 2002. Bethesda proposals for
classification of nonlymphoid hematopoietic neoplasms in mice. Blood. 100, 238-45. |
|
|
|
|
|
|
| HC Morse III,
J.M. Ward and M.A. Teitell. Mouse models of human B lymphoid neoplasms, IN:
I. Magrath, editor, The Lymphoid Neoplasms, 3ed, London: Hodder Arnold,
p 281-292, 2010. |
|
|
|
|
| Morse, H. C. I., et al., Mouse models of human B lymphoid
neoplasms. In: I. Magrath, et al., Eds.), The Lymphoid Neoplasms. Hodder
Arnold, London, 2010, pp. 281-292. |
|
|
|
|
|
| Morse, H. C., 3rd, et al., 2003. B lymphoid neoplasms of
mice: characteristics of naturally occurring and engineered diseases and
relationships to human disorders. Adv Immunol. 81, 97-121. |
|
|
|
| Morse, H. C., 3rd, et al., 2002. Bethesda proposals for
classification of lymphoid neoplasms in mice. Blood. 100, 246-58. |
|
|
|
|
|
|
| Rehg, J. E., et al., 2012. The utility of
immunohistochemistry for the identification of hematopoietic and lymphoid
cells in normal tissues and interpretation of proliferative and inflammatory
lesions of mice and rats. Toxicol Pathol. 40, 345-74. |
| Ward, J. M., 2006. Lymphomas and leukemias in mice. Exp
Toxicol Pathol. 57,
377-81. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|